Abstract
Objective
To evaluate the impact of metabolic and bariatric surgery (MBS) on plasma Fetuin-A expression, body mass index (BMI), and glucose levels in patients with obesity.
Methods
A systematic literature search was performed in PubMed, Cochrane Library, Web of science, and Embase following the PRISMA guidelines. A total of 5 studies (n = 298 participants) were included, reporting pre- and post-surgery plasma Fetuin-A levels, BMI, and glucose levels. Two independent reviewers extracted data, with discrepancies resolved by a third reviewer. Pooled standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated for each outcome. Heterogeneity was assessed using the I2 statistic.
Results
The pooled results revealed a significant reduction in plasma Fetuin-A levels post-surgery (SMD = −0.43, 95% CI = −0.73 to −0.14, P < .05, I2 = 60.7%). BMI also decreased significantly following MBS (SMD = −1.74, 95% CI = −2.28 to −1.19, P < .05, I2 = 84.2%). Additionally, glucose levels showed a marked reduction post-surgery (SMD = −0.94, 95% CI = −1.12 to −0.76, P < .05, I2 = 16.2%).
Conclusion
MBS is associated with significant reductions in plasma Fetuin-A levels, BMI, and glucose levels. These findings indicate that changes in Fetuin-A may accompany the metabolic improvements observed after MBS, although causal mechanisms cannot be established from the available evidence.
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Supplementary Material
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