Hemorrhage is the leading cause of preventable death in the United States and carries a disproportionately high mortality in pediatric patients. However, the literature surrounding pediatric trauma resuscitation, specifically massive transfusion protocol (MTP), is less robust than for adults. In this review, we assess the current state of the literature surrounding pediatric MTP (pMTP). Content experts in the field of trauma and pediatric surgery developed an algorithm to be used to identify cases requiring activation pMTP until a definitive scoring system that is both reliable and validated is created.
PhillipsRShahiNAckerSN, et al.Not as simple as ABC: tools to trigger massive transfusion in pediatric trauma. J Trauma Acute Care Surg. 2022;92:422-427. doi:10.1097/TA.0000000000003412.
4.
TheodorouCMGalganskiLAJurkovichGJ, et al.Causes of early mortality in pediatric trauma patients. J Trauma Acute Care Surg. 2021;90:574-581. doi:10.1097/TA.0000000000003045.
5.
CarmichaelSPLinNEvangelistaMEHolcombJB. The story of blood for shock resuscitation: how the pendulum swings. J Am Coll Surg. 2021;233:644-653. doi:10.1016/j.jamcollsurg.2021.08.001.
6.
HannaMKnittelJGillihanJ. The use of whole blood transfusion in trauma. Curr Anesthesiol Rep. 2022;12:234-239. doi:10.1007/s40140-021-00514-w.
7.
CapAndrew, et al.Damage control resuscitation. JOINT TRAUMA SYSTEM CLINICAL PRACTICE GUIDELINE (JTS CPG). 2019.
8.
BorgmanMASpinellaPCPerkinsJG, et al.The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. J Trauma. 2007;63:805-813. doi:10.1097/TA.0b013e3181271ba3.
9.
HolcombJBdel JuncoDJFoxEE, et al.The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks. JAMA Surg. 2013;148:127-136. doi:10.1001/2013.jamasurg.387.
10.
HolcombJBTilleyBCBaraniukS, et al.Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial. JAMA. 2015;313:471-482. doi:10.1001/jama.2015.12.
11.
ButlerEKMillsBMArbabiS, et al.Association of blood component ratios with 24-Hour mortality in injured children receiving massive transfusion. Crit Care Med. 2019;47:975-983. doi:10.1097/CCM.0000000000003708.
12.
CunninghamMERosenfeldEHZhuHNaik-MathuriaBJRussellRTVogelAM. A high ratio of plasma: RBC improves survival in massively transfused injured children. J Surg Res. 2019;233:213-220. doi:10.1016/j.jss.2018.08.007.
13.
MehlSCVogelAMGlasgowAE, et al.Prevalence and outcomes of high versus low ratio plasma to red blood cell resuscitation in a multi-institutional cohort of severely injured children. J Trauma Acute Care Surg. 2024;97:452-459. doi:10.1097/TA.0000000000004301.
14.
GainesBAYazerMHTriulziDJ, et al.Low titer group O whole blood in injured children requiring massive transfusion. Ann Surg. 2023;277:e919-e924. doi:10.1097/SLA.0000000000005251.
15.
McQuiltenZKFlintAWGreenLSandersonBWinearlsJWoodEM. Epidemiology of massive transfusion - a common intervention in need of a definition. Transfus Med Rev. 2021;35:73-79. doi:10.1016/j.tmrv.2021.08.006.
ShroyerMCGriffinRLMortellaroVERussellRT. Massive transfusion in pediatric trauma: analysis of the national Trauma databank. J Surg Res. 2017;208:166-172. doi:10.1016/j.jss.2016.09.039.
18.
KamyszekRWLeraasHJReedC, et al.Massive transfusion in the pediatric population: a systematic review and summary of best-evidence practice strategies. J Trauma Acute Care Surg. 2019;86:744-754. doi:10.1097/TA.0000000000002188.
19.
HolcombJBWadeCEMichalekJE, et al.Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients. Ann Surg. 2008;248:447-458. doi:10.1097/SLA.0b013e318185a9ad.
20.
KuaJPHOngGYKNgKC. Physiologically-guided balanced resuscitation: an evidence-based approach for acute fluid management in paediatric major trauma. Ann Acad Med Singapore. 2014;43:595-604.
21.
LivingstonMHSinghSMerrittNH. Massive transfusion in paediatric and adolescent trauma patients: incidence, patient profile, and outcomes prior to a massive transfusion protocol. Injury. 2014;45:1301-1306. doi:10.1016/j.injury.2014.05.033.
22.
NeffLPCannonJWMorrisonJJEdwardsMJSpinellaPCBorgmanMA. Clearly defining pediatric massive transfusion: cutting through the fog and friction with combat data. J Trauma Acute Care Surg. 2015;78:22-28. doi:10.1097/TA.0000000000000488.
23.
MorganKMGainesBARichardsonWMStrotmeyerSLeeperCM. Recognizing life-threatening bleeding in pediatric trauma: a standard for when to activate massive transfusion protocol. J Trauma Acute Care Surg. 2023;94:101-106. doi:10.1097/TA.0000000000003784.
24.
AndrewMPaesBJohnstonM. Development of the hemostatic system in the neonate and young infant. Am J Pediatr Hematol Oncol. 1990;12:95-104. doi:10.1097/00043426-199021000-00019.
25.
ParmarNAlbisettiMBerryLRChanAKC. The fibrinolytic system in newborns and children. Clin Lab. 2006;52:115-124.
26.
SitaruAGHolzhauerSSpeerCP, et al.Neonatal platelets from cord blood and peripheral blood. Platelets. 2005;16:203-210. doi:10.1080/09537100400016862.
27.
AndrewMPaesBBowkerJVeghP. Evaluation of an automated bleeding time device in the newborn. Am J Hematol. 1990;35:275-277. doi:10.1002/ajh.2830350411.
28.
Del VecchioALatiniGHenryEChristensenRD. Template bleeding times of 240 neonates born at 24 to 41 weeks gestation. J Perinatol. 2008;28:427-431. doi:10.1038/jp.2008.10.
29.
AppelIMGrimminckBGeertsJStigterRCnossenMHBeishuizenA. Age dependency of coagulation parameters during childhood and puberty. J Thromb Haemostasis. 2012;10:2254-2263. doi:10.1111/j.1538-7836.2012.04905.x.
30.
Ferrer-MarínFSola-VisnerM. Neonatal platelet physiology and implications for transfusion. Platelets. 2022;33:14-22. doi:10.1080/09537104.2021.1962837.
31.
GuptaSSankarJ. Advances in shock management and fluid resuscitation in children. Indian J Pediatr. 2023;90:280-288. doi:10.1007/s12098-022-04434-3.
32.
DavisALCarcilloJAAnejaRK, et al.American college of critical care medicine clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock. Crit Care Med. 2017;45:1061-1093. doi:10.1097/CCM.0000000000002425.
33.
PowellEKHinckleyWRGottulaAHartKWLindsellCJMcMullanJT. Shorter times to packed red blood cell transfusion are associated with decreased risk of death in traumatically injured patients. J Trauma Acute Care Surg. 2016;81:458-462. doi:10.1097/TA.0000000000001078.
34.
JungJEoEAhnKNohHCheonY. Initial base deficit as predictors for mortality and transfusion requirement in the severe pediatric trauma except brain injury. Pediatr Emerg Care. 2009;25:579-581. doi:10.1097/PEC.0b013e3181b9b38a.
35.
PhillipsRAckerSNShahiN, et al.The ABC-D score improves the sensitivity in predicting need for massive transfusion in pediatric trauma patients. J Pediatr Surg. 2020;55:331-334. doi:10.1016/j.jpedsurg.2019.10.008.
36.
SullivanTMGestrich-ThompsonWVMilestoneZPBurdRS. Time is tissue: barriers to timely transfusion after pediatric injury. J Trauma Acute Care Surg. 2023;94:S22-S28. doi:10.1097/TA.0000000000003752.
37.
BairdEWLammersDTAbrahamPJ, et al.Outcomes of patients enrolled in a prospective and randomized trial on basis of gestalt assessment or ABC score. J Trauma Acute Care Surg. 2024;96:876-881. doi:10.1097/TA.0000000000004276.
38.
MotameniATHodgeRAMcKinleyWI, et al.The use of ABC score in activation of massive transfusion: the yin and the yang. J Trauma Acute Care Surg. 2018;85:298-302. doi:10.1097/TA.0000000000001949.
39.
YoungPPBorgePD. Making whole blood for trauma available (again): the AMERICAN red cross experience. Transfusion (Paris). 2019;59:1439-1445. doi:10.1111/trf.15166.
40.
LeeperCMYazerMHCladisFPSaladinoRTriulziDJGainesBA. Use of uncrossmatched cold-stored whole blood in injured children with hemorrhagic shock. JAMA Pediatr. 2018;172:491-492. doi:10.1001/jamapediatrics.2017.5238.
41.
MorganKMYazerMHTriulziDJStrotmeyerSGainesBALeeperCM. Safety profile of low-titer group O whole blood in pediatric patients with massive hemorrhage. Transfusion (Paris). 2021;61(Suppl 1):S8-S14. doi:10.1111/trf.16456.
42.
LeeperCMYazerMHMorganKMTriulziDJGainesBA. Adverse events after low titer group O whole blood versus component product transfusion in pediatric trauma patients: a propensity-matched cohort study. Transfusion (Paris). 2021;61:2621-2628. doi:10.1111/trf.16509.
43.
LeeperCMYazerMHTriulziDJNealMDGainesBA. Whole blood is superior to component transfusion for injured children: a propensity matched analysis. Ann Surg. 2020;272:590-594. doi:10.1097/SLA.0000000000004378.
44.
PereaLLMooreKDochertyC, et al.Whole blood resuscitation is safe in pediatric trauma patients: a multicenter study. Am Surg. 2023;89:3058-3063. doi:10.1177/00031348231157864.
45.
RussellRTEsparazJRBeckwithMA, et al.Pediatric traumatic Hemorrhagic shock consensus conference recommendations. J Trauma Acute Care Surg. 2023;94:S2-S10. doi:10.1097/TA.0000000000003805.
46.
RobertsIShakurHCoatsT, et al.The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients. Health Technol Assess. 2013;17:1-79. doi:10.3310/hta17100.
47.
HameleMAdenJKBorgmanMA. Tranexamic acid in pediatric combat trauma requiring massive transfusions and mortality. J Trauma Acute Care Surg. 2020;89:S242-S245. doi:10.1097/TA.0000000000002701.
48.
DitzelRMAndersonJLEisenhartWJ, et al.A review of transfusion- and trauma-induced hypocalcemia: is it time to change the lethal triad to the lethal diamond?J Trauma Acute Care Surg. 2020;88:434-439. doi:10.1097/TA.0000000000002570.
49.
WebsterSToddSRedheadJWrightC. Ionised calcium levels in major trauma patients who received blood in the emergency department. Emerg Med J. 2016;33:569-572. doi:10.1136/emermed-2015-205096.
MagnottiLJBradburnEHWebbDL, et al.Admission ionized calcium levels predict the need for multiple transfusions: a prospective study of 591 critically ill trauma patients. J Trauma. 2011;70:391-395. doi:10.1097/TA.0b013e31820b5d98.
52.
MacKayEJStubnaMDHolenaDN, et al.Abnormal calcium levels during trauma resuscitation are associated with increased mortality, increased blood product use, and greater hospital resource consumption: a pilot investigation. Anesth Analg. 2017;125:895-901. doi:10.1213/ANE.0000000000002312.
53.
Abou KhalilEFeeneyEMorganKMSpinellaPCGainesBALeeperCM. Impact of hypocalcemia on mortality in pediatric trauma patients who require transfusion. J Trauma Acute Care Surg. 2024;97:242-247. doi:10.1097/TA.0000000000004330.
54.
AckerSNRossJTPartrickDATongSBensardDD. Pediatric specific shock index accurately identifies severely injured children. J Pediatr Surg. 2015;50:331-334. doi:10.1016/j.jpedsurg.2014.08.009.
55.
MergoumAMMergoumASLarsonNJ, et al.Tranexamic acid use in the surgical arena: a narrative review. J Surg Res. 2024;302:208-221. doi:10.1016/j.jss.2024.07.042.
56.
HenryS. ATLS advanced trauma life support 10th edition student course manual. 2018.
57.
PoderTGNonkaniWGTsakeu LeponkouoÉ. Blood warming and hemolysis: a systematic review with meta-analysis. Transfus Med Rev. 2015;29:172-180. doi:10.1016/j.tmrv.2015.03.002.
58.
RaviPRPuriB. Fluid resuscitation in haemorrhagic shock in combat casualties. Disaster Mil Med. 2017;3:2. doi:10.1186/s40696-017-0030-2.
59.
HannaKBibleLChehabM, et al.Nationwide analysis of whole blood hemostatic resuscitation in civilian trauma. J Trauma Acute Care Surg. 2020;89:329-335. doi:10.1097/TA.0000000000002753.