Background: Surgeons experience high levels of burnout, impacting both their personal and professional lives in negative ways. Purpose: This review discusses individual and organizational level interventions affecting surgeons’ relationships at home and work. The authors use Maslow’s Hierarchy of Needs to explore the importance of psychological needs that impact surgeons’ well-being and performance. Research Design: A thorough search of the literature was conducted to assess interventions that are likely to affect surgeons’ personal and professional relationships. Analysis: The literature review included papers focused on research on surgeons’ burnout, stress, well-being, personal partner, workplace team dynamics, and workplace culture/environment. Results: The review underscores the importance of relationships at home and work, a sense of belonging, and self-esteem as they relate to surgeons’ well-being. Highlighted are individual and organizational strategies to enhance well-being. Conclusions: Strong personal and professional relationships positively impact surgeons’ flourishing and should be taken into consideration at the individual and organizational level.