Indeterminate Thyroid Nodule: Knowing What We Do Not Know

American Cancer SocietyCancer Facts & Figures 2014. Atlanta, Ga: American Cancer Society; 2014. Available at http://www.cancer.org/cancer/thyroidcancer/detailedguide/thyroid-cancer-key-statistics. Accessed November 19, 2014.

Nikiforov Y.E. , Ohori N.P. , Hodak S.P. Impact of mutational testing on the diagnosis and management of patients with cytologically indeterminate thyroid nodules: a prospective analysis of 1056 FNA samples. J Clin Endocrinol Metab 2011; 96: 3390–7.

Alexander E.K. , Kennedy G.C. , Baloch Z.W. Preoperative diagnosis of benign thyroid nodules with indeterminate cytology. N Engl J Med 2012; 367: 705–15.

Alexander E.K. , Schorr M. , Klopper J. Multicenter clinical experience with the Afirma gene expression classifier. J Clin Endocrinol Metab 2014; 99: 119–25.

Lastra R.R. , Pramick M.R. , Crammer C.J. Implications of a suspicious Afirma test result in thyroid fine-needle aspiration cytology: an institutional experience. Cancer Cytopathol 2014; 122: 737–44.

McIver B. , Castro M.R. , Morris J.C. An independent study of a gene expression classifier (Afirma) in the evaluation of cytologically indeterminate thyroid nodules. J Clin Endocrinol Metab 2014; 99: 4069–77.