Article Commentary: Glucose Control and Its Implications for the General Surgeon

Angus D.C. , Abraham E. Intensive insulin therapy in critical illness: When is the evidence enough? Am J Respir Crit Care Med 2005; 172: 1358–9.

American Diabetes Association. Summary of revisions of the 2008 Clinical Practice Recommendations. Diabetes Care 2008; 31: S3–4.

Joint Commission's Certification for Disease Specific Care. Available at http://www.jointcommission.org/NR/rdonlyres/2933D499-84CC-4EC1-83A2-6990DDC7D977/0/Mktg_DSC_Brochure.pdf. Accessed December 2008.

Holman R.R. , Paul S.K. , Bethel M.A. 10-year follow-up of intensive glucose control in Type 2 diabetes. N Engl J Med 2008; 359: 1577–89.

Khoury W. , Klausner J.M. , Ben-Abraham R. , Szold O. Glucose control by insulin for critically ill surgical patients. J Trauma 2004; 57: 1132–8.

Sidenius P. The axonopathy of diabetic neuropathy. Diabetes 1982; 31: 356–63.

Wahab N.N. , Cowden E.A. , Pearce N.J. Is blood glucose an independent predictor of mortality in acute myocardial infarction in the thrombolytic era? J Am Coll Cardiol 2002; 40: 1748–54.

Latham R. , Lancaster A.D. , Covington J.F. The association of diabetes and glucose control with surgical-site infections among cardiothoracic surgery patients. Infect Control Hosp Epidemiol 2001; 22: 607–12.

Parsons M.W. , Barber P.A. , Desmond P.M. Acute hyperglycemia adversely affects stroke outcome: A magnetic resonance imaging and spectroscopy study. Ann Neurol 2002; 52: 20–8.

Umpierrez G.E. , Isaacs S.D. , Bazargan N. Hyperglycemia: An independent marker of in-hospital mortality in patients with undiagnosed diabetes. J Clin Endocrinol Metab 2002; 87: 978–82.

Whitcomb B.W. , Pradhan E.K. , Pittas A.G. Impact of admission hyperglycemia on hospital mortality in various intensive care unit populations. Crit Care Med 2005; 33: 2772–7.

Yendamuri S. , Fulda G.J. , Tinkoff G.H. Admission hyperglycemias a prognostic indicator in trauma. J Trauma 2003; 55: 33–8.

Cochran A. , Scaife E.R. , Hansen K.W. , Downey E.C. Hyperglycemia and outcomes from pediatric traumatic brain injury. J Trauma 2003; 55: 1035–8.

Bochicchio G.V. , Joshi M. , Bochicchio K.M. Early hyperglycemic control is important in critically injured trauma patients. J Trauma 2007; 63: 1353–9.

Laird A.M. , Miller P.R. , Kilgo P.D. Relationship of early hyperglycemia to mortality in trauma patients. J Trauma 2004; 56: 1058–62.

Bochicchio G.V. , Salzano L. , Joshi M. Admission pre-operative glucose is predictive of morbidity and mortality in trauma patients who require immediate operative intervention. Am Surg 2005; 71: 171–4.

Zuckerbraun B.S. , Harbrecht B.G. The physiologic response to injury. In: Peitzman A.B. , Rhodes M. , Schwab C.W. , Yealy D.M. , Fabian T.C. , eds. The Trauma Manual: Trauma and Acute Care Surgery. Philadelphia: Wolters Kluwer/LWW, 2008, pp 23–8.

Sperry J.L. , Frankel H.L. , Vanek S.L. Early hyperglycemia predicts multiple organ failure and mortality but not infection. J Trauma 2007; 63: 487–94.

Martin R.S. , Smith J.S. , Hoth J.J. Increased insulin requirements are associated with pneumonia after severe injury. J Trauma 2007; 63: 358–64.

Gale S.C. , Sicoutris C. , Reilly P.M. Poor glycemic control is associated with increased mortality in critically ill trauma patients. Am Surg 2007; 73: 454–60.

Van den Berghe G. , Wouters P. , Weekers F. Intensive insulin therapy in critically ill patients. N Engl J Med 2001; 345: 1359–67.

Krinsley J.S. Effect of an intensive glucose management protocol on the mortality of critically ill adult patients. Mayo Clin Proc 2004; 79: 992–1000.

Finney S.J. , Zekveld C. , Elia A. , Evans T.W. Glucose control and mortality in critically ill patients. JAMA 2003; 290: 2041–7.

Krinsley J.S. Glycemic control, diabetes status, and mortality in a heterogenous population of critically ill patients before and during the era of intensive glycemic management: Six and one-half years experience at a university-affiliated community hospital. Semin Thorac Cardiovasc Surg 2006; 18: 317–25.

Van den Berghe G. , Wilmer A. , Hermans G. Intensive insulin therapy in the medical ICU. N Engl J Med 2006; 354: 449–61.

Van den Berghe G. , Schoonheydt K. , Becx P. Insulin therapy protects the central and peripheral nervous system of intensive care patients. Neurology 2005; 64: 1348–53.

Mesotten D. , Swinnen J.V. , Vanderhoydone F. Contribution of circulating lipids to the improved outcome of critical illness by glycemic control with intensive insulin therapy. J Clin Endocrinol Metab 2004; 89: 219–26.

Vanhorebeek I. , DeVos R. , Mesotten D. Protection of hepatocyte mitochondrial ultrastructure and function by strict blood glucose control with insulin in critically ill patients. Lancet 2005; 365: 53–9.

Van den Berghe G. , Wouters P.J. , Bouillon R. Outcome benefit of intensive insulin therapy in the critically ill: Insulin dose versus glycemic control. Crit Care Med 2003; 31: 359–66.

Van den Berghe G. , Wouters P.J. , Kesteloot K. , Hilleman D.E. Analysis of healthcare resource utilization with intensive insulin therapy in critically ill patients. Crit Care Med 2006; 34: 612–6.

Krinsley J.S. , Jones R.L. Cost analysis of intensive glycemic control in critically ill adult patients. Chest 2006; 129: 646–50.

Pham T.N. , Warren A.J. , Phan H.H. Impact of tight glycemic control in severely burned children. J Trauma 2005; 59: 1148–54.

Reed C.C. , Stewart R.M. , Sherman M. Intensive insulin protocol improves glucose control and is associated with a reduction in intensive care unit mortality. J Am Coll Surg 2007; 204: 1048–55.

Scalea T.M. , Bochicchio G.V. , Bochicchio K.M. Tight glycemic control in critically injured trauma patients. Ann Surg 2007; 246: 605–12.

Hemmila M.R. , Taddonio M.A. , Arbabi S. Intensive insulin therapy is associated with reduced infectious complications in burn patients. Surgery 2008; 144: 629–37.

Toschlog E.A. , Newton C. , Allen N. Morbidity reduction in critically ill trauma patients through use of a computerized insulin infusion protocol: A preliminary study. J Trauma 2007; 62: 1370–6.

Wahl W.L. , Taddonio M. , Maggio P.M. Mean glucose values predict trauma patient mortality. J Trauma 2008; 65: 42–8.

Collier B. , Diaz J. Jr. , Forbes R. The impact of a normoglycemic management protocol on clinical outcomes in the trauma intensive care unit. J Paren Ent Nutr 2005; 29: 353–9.

Egi M. , Bellomo R. , Stachowski E. Circadian rhythm of blood glucose values in critically ill patients. Crit Care Med 2007; 35: 416–21.

Kanji S. , Buffie J. , Hutton B. Reliability of point-of-care testing for glucose measurement in critically ill adults. Crit Care Med 2005; 33: 2778–85.

Hoedemaekers C.W. , Gunnewiek J.M.T.K. , Prinsen M.A. Accuracy of bedside glucose measurement from three glucometers in critically ill patients. Crit Care Med 2008; 36: 3062–6.

Mann E.A. , Salinas J. , Pidcoke H.F. Error rates resulting from anemia can be corrected in multiple commonly used point-of-care glucometers. J Trauma 2008; 64: 15–21.

Egi M. , Bellomo R. , Stachowski E. Intensive insulin therapy in postoperative intensive care unit patients: A decision analysis. Am J Respir Crit Care Med 2006; 173: 407–13.

Preiser J.C. , Devos P. Clinical experience with tight glucose control by intensive insulin therapy. Crit Care Med 2007; 35: S502–7.

Harbrecht B.G. Control of glucose after injury. Am Surg 2008; 74: 199–200.

Devos P. , Preiser J.C. Current controversies around tight glucose control in critically ill patients. Curr Opin Clin Nutr Metab Care 2007; 10: 206–9.

Brunkhorst F.M. , Engel C. , Bloos F. Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 2008; 358: 125–39.

Arabi Y.M. , Dabbagh O.C. , Tamim H.M. Intensive versus conventional insulin therapy: A randomized controlled trial in medical and surgical criticallyill patients. Crit Care Med 2008; 36: 3190–7.

Treggiari M.M. , Karir V. , Yanez N.D. Intensive insulin therapy and mortality in critically ill patients. Crit Care 2008; 12: R29.

Wiener R.S. , Wiener D.C. , Larson R.J. Benefits and risks of tight glucose control in critically ill adults: A meta-analysis. JAMA 2008; 300: 933–44.

Oddo M. , Schmidt J.M. , Mayer S.A. , Chiolero R.L. Glucose control after severe brain injury. Curr Opin Clin Nutr Metab Care 2008; 11: 134–9.

Oddo M. , Schmidt J.M. , Carrera E. Impact of tight glucose control on cerebral glucose metabolism after severe brain injury: A microdialysis study. Crit Care Med 2008; 36: 3233–8.

Taubes G. Paradoxical effects of tightly controlled blood sugar. Science 2008; 322: 365–7.

Duckworth W. , Abraira C. , Moritz T. Glucose control and vascular complications in Veterans with Type 2 diabetes. N Engl J Med 2009; 360: 129–39.

Krinsley J.S. , Grover A. Severe hypoglycemia in critically ill patients: Risk factors and outcomes. Crit Care Med 2007; 35: 2262–7.

Egi M. , Bellomo R. , Stachowski E. Variability of blood glucose concentration and short-term mortality in critically ill patients. Anesthesiology 2006; 105: 244–52.

Ali N.A. , O'Brien J.M. Jr. , Dungan K. Glucose variability and mortality in patients with sepsis. Crit Care Med 2008; 36: 2316–21.

Dossett L.A. , Cao H. , Mowery N.T. Blood glucose variability is associated with mortality in the surgical intensive care unit. Am Surg 2008; 74: 679–85.

Krinsley J.S. Glycemic variability: A strong independent predictor of mortality in critically ill patients. Crit Care Med 2008; 36: 3008–13.