Matteo Realdo Colombo (c. 1516–1559) was one of the great anatomists and teachers of the Renaissance period. He has created a lasting reputation by both challenging incorrect medical convention and influencing the great artwork of the time. Although Colombo's contemporaries are often held in greater esteem, the accomplishments of this anatomist helped set the stage for modern medicine. The story of Colombo's life provides the modern surgeons and anatomist with valuable lessons regarding the nature of orthodoxy, conflict, and the evolving nature of “truth” in science.
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