Apocrine adenocarcinoma is a rare malignancy with invasive potential. Its clinical behavior and histologic appearance are highly variable, making accurate diagnosis difficult. We report on a case of apocrine carcinoma presenting with lymph node infiltration and extensive extramammary Paget's disease. Wide local excision with lymph node dissection is the mainstay of treatment. The role of adjuvant therapy has yet to be established.
Get full access to this article
View all access options for this article.
References
1.
GoldsteinD.J., BarrR.J., Santa CruzD.J.Microcystic adnexal carcinoma: A distinct clinicopathologic entity.Cancer1982; 50: 566–72.
2.
ShintakuM., TsutaK., YoshidaH.Apocrine adenocarcinoma of the eyelid with aggressive biological behavior: Report of a case.Pathol Int2002; 52: 169–73.
3.
BakerD.J., HeymannW.R.Eccrine Glands and Apocrine Glands.Schaumburg, IL: American Academy of Dermatology, 2003.
4.
DhawanS.S., NandaV.S., GrekinS., RabinovitzH.S.Apocrine adenocarcinoma: Case report and review of the literature.J Dermatol Surg Oncol1990; 16: 468–70.
5.
BergJ.W., McDivittR.W.Pathology of sweat gland carcinoma.Pathol Annu1968; 3: 123–44.
6.
Moreno-AriasG.A., ConillC., Sola-CasasM.A.Radiotherapy for in situ extramammary Paget disease of the vulva.J Dermatolog Treat2003; 14: 119–23.
7.
QianZ., ZeitounN.C., ShiehS.Successful treatment of extramammary Paget's disease with imiquimod.J Drugs Dermatol2003; 2: 73–6.
8.
WangL.C., BlanchardA., JudgeD.E.Successful treatment of recurrent extramammary Paget's disease of the vulva with topical imiquimod 5% cream.J Am Acad Dermatol2003; 49: 769–72.
9.
BermanB., SpencerJ., VillaA.Successful treatment of extramammary Paget's disease of the scrotum with imiquimod 5% cream.Clin Exp Dermatol2003; 28(Suppl 1): 36–8.
10.
ZampognaJ.C., FlowersF.P., RothW.I., HasseneinA.M.Treatment of primary limited cutaneous extramammary Paget's disease with topical imiquimod monotherapy: Two case reports.J Am Acad Dermatol2002; 47(4 Suppl): S229–35.