Metastatic lesions to the testicle are uncommon. The authors report a testicular mass as the initial manifestation of distant metastasis from colorectal cancer. This case describes a 51-year-old white man who presented with an enlarged right testicle 9 months after undergoing a right hemicolectomy for a stage IIIC colon adenocarcinoma. The diagnostic and management strategy is discussed. In addition, the literature is reviewed to characterize this uncommon entity further. Although rare, testicular metastasis must be considered in patients with previously resected colorectal carcinoma.
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References
1.
MeachamR.B., MataJ.A., EspadaR.Testicular metastasis as the first manifestation of colon carcinoma.J Urol1988; 140: 621–2.
2.
TiongH.Y., KewC.Y., TanK.B.Metastatic testicular carcinoma from the colon with clinical, immunophenotypical, and molecular characterization: Report of a case.Dis Colon Rectum2005; 48: 582–5.
JubelirerS.J.Metastatic colonic carcinoma to the testes: Case report and review of the literature.J Surg Oncol1986; 32: 22–4.
5.
PolychronidisA., TsolosC., SirvidisE.Spermatic cord metastasis as an initial manifestation of sigmoid colon carcinoma: Report of a case.Surg Today2002; 32: 376–7.
6.
DuttN., BatesA.W., BaithunS.I.Secondary neoplasms of the male genital tract with different patterns of involvement in adults and children.Histopathology2000; 37: 323–31.
7.
HampelH., FrankelW.L., MartinE.Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer).N Engl J Med2005; 352: 1851–60.
8.
GryfeR., KimH., HsiehE.T.K.Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer.N Engl J Med2000; 342: 69–77.
9.
EliasD., CavalcantiA.Resection of liver metastases from colorectal cancer: The real impact of the surgical margin.Eur J Surg Oncol1998; 24: 174–9.
10.
PawlikT.M., ScogginsC.R.Effect of surgical margin status on survival and site of recurrence after hepatic resection for colorectal metastases.Ann Surg2005; 241: 715–22.
11.
WoodT.F., RoseD.M.Radiofrequency ablation of 231 unresectable hepatic tumors: Indications, limitations, and complications.Ann Surg Oncol2000; 7: 593–600.
12.
RegnardJ.F., GrunenwaldD.Surgical treatment of hepatic and pulmonary metastases from colorectal cancers.Ann Thorac Surg1998; 66: 214–8.
13.
AdamR., AvisarE.Five-year survival following hepatic resection after neoadjuvant therapy for nonresectable colorectal.Ann Surg Oncol2001; 8: 347–53.
14.
HurwitzH., KabbinavarF.Bevacizumab combined with standard fluoropyrimidine-based chemotherapy regimens to treat colorectal cancer.Oncology2005; 69(Suppl 3): 17–24.
15.
SunW., HallerD.G.Adjuvant therapy of colon cancer.Semin Oncol2005; 32: 95–102.
16.
HauptH.M., MannR.B., TrumpD.L., AbeloffM.D.Metastatic carcinoma involving the testis. Clinical and pathologic distinction from primary testicular neoplasms.Cancer1984; 54: 709–14.
17.
AgrawalS., YaoT.J., CoitD.G.Surgery for melanoma metastatic to the gastrointestinal tract.Ann Surg Oncol1999; 6: 336–44.
18.
PovoskiS.P., OuelletteJ.R., ChangW.W.L., JarnaginW.R.Axillary lymph node metastasis following resection of abdominal wall laparoscopic port site recurrence of gallbladder cancer.J Hepatobiliary Pancreat Surg2004; 11: 197–202.
19.
AugustD.A., SugarbakerP.H.Lymphatic dissemination of hepatic metastases: Implications for the follow-up and treatment of patients with colorectal cancer.Cancer1985; 55: 1490–4.
20.
RodgersM.S., McCallJ.L.Surgery for colorectal liver metastases with hepatic lymph node involvement: A systematic review.Br J Surg2000; 87: 1142–55.
21.
EliasD.M., OuelletJ.F.Incidence, distribution, and significance of hilar lymph node metastases in hepatic colorectal metastases.Surg Oncol Clin North Am2003; 12: 221–32.
