Human papillomavirus is a possible risk factor in the development of squamous cell carcinoma. We report the case of a 21-year-old African-American male who presented with coughing and shortness of breath. He had been treated with multiple cauteries and ablations for problems associated with HPV since childhood. A CT scan revealed bilateral cavitary lung lesions. These lesions were resected through staged thoracotomies and revealed synchronous squamous cell carcinomas.
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References
1.
ChenY.C., ChenJ.H., RichardK.Lung adenocarcinoma and human papillomavirus infection.Cancer2004; 101: 1428–36.
2.
ChiouH.L., WuM.F., LiawY.C.The presence of human papillomavirus type 16/18 DNA in blood circulation may act as a risk marker of lung cancer in Taiwan.Cancer2003; 97: 1558–63.
3.
Bejui-ThivoletF., ChardonnetY., PatricotL.M.Human papillomavirus type 11 DNA in papillary squamous cell lung carcinoma.Virchows Archiv A Pathol Anat1990; 417: 457–61.
4.
SimmaB., BuergerR., UehlingerJ.Squamous-cell carcinoma arising in a non-irradiated child with recurrent respiratory papillomatosis.Eur J Pediatr1993; 152: 776–8.
5.
SyrjänenK.J.HPV infections and lung cancer.J Clin Pathol2002; 55: 885–91.
6.
ZaferE., ErgunM.A., AlverG.Detection and typing of human papillomavirus in non-small cell lung cancer.Respiration2004; 71: 88–90.
7.
LeleS.M., PouA.M., VenturaK.Molecular events in the progression of recurrent respiratory papillomatosis to carcinoma.Arch Pathol Lab Med2002; 126: 1184–8.
8.
JiH., ChangE.Y., LinK.Y.Antigen-specific immunotherapy for murine lung metastatic tumors expressing human pappillomavirus type 16 E7 oncoprotein.Int J Cancer1998; 78: 41–5.
