Granulosa cell tumors account for 2 to 3 per cent of all ovarian neoplasms. This case report describes a patient with splenic rupture from a bulky metastatic deposit 29 years after her initial surgery. A review of the literature regarding the patterns and timing of recurrence is also discussed.
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References
1.
MalmstromH, HogbergT, RisbergB, SimonsenE. Granulosa cell tumors of the ovary: Prognostic factors and outcome. Gynecol Oncology1994;52:50–5.
2.
GuptaPB, HarveyL. Spontaneous rupture of the spleen secondary to metastatic carcinoma. Br J Surg1993;80:613.
HinesJF, KhalifaMA, MooreJL, . Recurrent granulosa cell tumor of the ovary 37 years after initial diagnosis: A case report and review of the literature. Gyncol Oncol1996;60:484–8.
5.
AyhanA, TuncerZS, TuncerR, . Granulosa cell tumor of the ovary: A clinicopathologic evaluation of 60 cases. Eur J Gynaecol Oncol1994;15:320–4.
6.
LaneAH, LeeMM, FullerAFJr, . Diagnostic utility of Mullerian inhibiting substance determination in patients with primary and recurrent granulosa cell tumors. Gynecol Oncol1999; 73:51–5.
7.
SegalR, DePetrilloAD, ThomasG. Clinical review of adult granulosa cell tumors of the ovary. Gyncol Oncol1995;56:338–44.
8.
KietlinskaZ, PietrzakK, DrabikM. The management of granulosa-cell tumors of the ovary based on long-term follow up. Eur J Gynaecol Oncol1993;14(Suppl):118–27.
9.
Rodriguez-GarciaJI, Gonzalez GonzalezJJ, Garcia FlorezLJ, . Hepatic metastases of granulosa cell tumour of the ovary. HPB Surg1996;10:55–7.
10.
SavageP, ConstenlaD, FisherC, . Granulosa cell tumor of the ovary: Demographics, survival and the management of advanced disease. Clin Oncol (R Coll Radio)1998;10:242–5.
11.
FontanelliR, StefanonB, RaspagliesiF, . Adult granulosa cell tumor of the ovary: A clinico-pathologic study of 35 cases. Tumori1998;84:60–4.
12.
StageAH, GraftonWD. Thecomas and granulosa-theca cell tumors of the ovary: An analysis of 51 tumors. Obstet Gynecol1977;50:21–7.
13.
ThirumalaSD, PuttiTC, MedalieNS, WassermanG. Skeletal metastases from a granulosa cell tumor of the ovary. Diagn Cytopathol1998;19:375–7.
14.
Ayala GarzaP, Garcia-CompeanD, Barragan VillarrealRF, . Granulosa cell tumor with liver metastases treated with partial hepatectomy and chemoradiation. Rev Gastroenterol Mex1992;57:179–82.
15.
PankratzE, BoyesDA, WhiteGW, . Granulosa cell tumors: A clinical review of 61 cases. Obstet Gynecol1978;52: 718–23.
16.
SommersSC, GatesO, GoodofII. Late recurrence of granulosa cell tumor of the ovary: A Report of Two Cases. Obstet Gynecol1955;6:395.
17.
AliSZ. Metastatic granulosa-cell tumor in the liver: Cytopathologic findings and staining with inhibin. Diagnostic Cytopatholo1998;19:293–7.
18.
LuschCJ, MercurioTM, RunyeonWK. Delayed recurrence and chemotherapy of granulosa cell tumor. Obstet Gynecol1978; 51:505–7.
19.
FoxH, AgrawalK, LangleyFA. A clinicopathologic study of 92 cases of granulosa cell tumors of the ovary with special reference to factors influencing prognosis. Cancer1975;35: 231–41.
20.
NorrisHJ, TaylorHB. Prognosis of granulosa-theca tumors of the ovary. Cancer1968;21:255–63.
21.
StenwigJT, HazekampJT, BeechamJB. Granulosa and theca cell tumors: A clinicopathological study of 118 cases with long-term follow-up. Obstet Gynecol1979:7:136–52.
22.
LiMK, van der WaltJD. Recurrent granulosa cell tumor of the ovary 22 years after primary excision. J R Coll Surg Edinb1984;29:192–4.
23.
EvansAT3d, GaffeyTA, MalkasianGDJr, AmegersJF. Clinicopathologic review of 118 granulosa and theca cell tumors. Obstet Gynecol1980;55:231–8.
24.
AnikwueC, DawoodMY, KreimerE. Granulosa and theca cell tumors. Obstet Gynecol1978;51:214–20.
25.
AsschenfeldtP, ThindP. Granulosa cell tumor: A case with primary peritoneal carcinomatosis and recurrence after 24 years. UgeskrLaeger1984;46:1938.
26.
PiuraB, NemetD, Yanai-InbarI, . Granulosa cell tumor of the ovary: A study of 18 cases. J Surg Oncol1994;55:71–7.
27.
PalSK, ChowdhuryNN. Late recurrence of granulosa cell tumor. Asia Oceania J Obstet Gynaecol1986;12:21–3.
