Third International Stroke Trial

World Health Organisation: Global Burden of Disease, (www document) http://www.who.int/trade/glossary/story036/en/ 2006.

Hudson J Scharaschkin A Wilkins M Taylor K : Reducing Brain Damage: Faster Access to Better Stroke Care. London: National Audit Office, 2005.

Warlow C Sudlow C Dennis M Wardlaw J Sandercock P : Stroke. Lancet 2003; 362:2121–2.

Chen ZM Sandercock P Pan HC . Indications for early aspirin use in acute ischemic stroke: a combined analysis of 40 000 randomized patients from the Chinese acute stroke trial and the international stroke trial. Stroke 2000; 31:1240–9.

Hankey GJ Warlow CP : Treatment and secondary prevention of stroke: evidence, costs, and effects on individuals and populations. Lancet 1999; 354:1457–63.

Wardlaw JM del Zoppo G Yamaguchi T Berge E : Thrombolysis for acute ischaemic stroke (Cochrane review), 2003: Art. No.: CD000213. DOI: 10.1002/14651858.CD000213.

Hacke W Donnan G Fieschi C . Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet 2004; 363:768–74.

Schneider AT Pancioli AM Khoury JC . Trends in community knowledge of the warning signs and risk factors for stroke. JAMA 2003; 289:343–6.

Kwan J Hand P Sandercock P : A systematic review of barriers to delivery of thrombolysis for acute stroke. Age Ageing 2004; 33:116–21.

Bambauer KZ Johnston SC Bambauer DE Zivin JA : Reasons why few patients with acute stroke receive tissue plasminogen activator. Arch Neurol 2006; 63:661–4.

Rothwell PM Coull AJ Giles MF . Change in stroke incidence, mortality, case-fatality, severity, and risk factors in Oxfordshire, UK from 1981 to 2004 (Oxford Vascular Study). Lancet 2004; 363:1925–33.

van Oostenbrugge RJ Hupperts RM Lodder J : Thrombolysis for acute stroke with special emphasis on the very old: experience from a single Dutch centre. J Neurol Neurosurg Psychiatry 2006; 77:375–7.

Wardlaw JM Mielke O : Early signs of brain infarction at CT: observer reliability and outcome after thrombolytic treatment-systematic review. Radiology 2005; 235:444–53.

Collins R MacMahon S : Reliable assessment of the effects of treatment on mortality and major morbidity, I: clinical trials. Lancet 2001; 357:373–80.

The Paul Coverdell Prototype Registries Writing Group*: Acute stroke care in the US: results from 4 pilot prototypes of the Paul coverdell national acute stroke registry. Stroke 2005; 36:1232–40.

Heuschmann PU Berger K Misselwitz B . Frequency of thrombolytic therapy in patients with acute ischemic stroke and the risk of in-hospital mortality: the German stroke registers study group. Stroke 2003; 34:1106–13.

(www document) http://www.acutestroke.org/index.php (accessed 2006).

Brown DL Barsan WG Lisabeth LD Gallery ME Morgenstern LB : Survey of emergency physicians about recombinant tissue plasminogen activator for acute ischemic stroke. Ann Emerg Med 2005; 46:56–60.

Sandercock P Berge E Dennis M . Cost-effectiveness of thrombolysis with recombinant tissue plasminogen activator for acute ischemic stroke assessed by a model based on UK NHS costs. Stroke 2004; 35:1490–7.

Schulz KF Grimes DA : Multiplicity in randomised trials II: subgroup and interim analyses. Lancet 365:1657–61.

Koops L Lindley RI : Thrombolysis for acute ischaemic stroke: consumer involvement in design of new randomised controlled trial. BMJ 2002; 325:415.

Kane I Lindley R Lewis S Sandercock P : Impact of stroke syndrome and stroke severity on the process of consent in the Third International Stroke Trial. Cerebrovasc Dis 2006; 21:348–52.

European Carotid Surgery Trialists' Group: MRC European carotid surgery trial: interim results for symptomatic patients with severe (70–99%) or with mild (0–29%) carotid stenosis. European carotid surgery trialists' collaborative group. Lancet 1991; 337:1235–43.

Molyneux A : International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial. Lancet 2002; 360:1267–74.

Roberts I Yates D Sandercock P . Effect of intravenous corticosteroids on death within 14 days in 10,008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial. Lancet 2004; 364:1321–8.

Wardlaw JM Sellar R : A simple practical classification of cerebral infarcts on CT and its interobserver reliability. Am J Neuroradiol 1994; 15:1933–9.

Ketley D Woods KL : Impact of clinical trials on clinical practice: example of thrombolysis for acute myocardial infarction. Lancet 1993; 342:891–4.