16 th International Headache Research Seminar March 23–25,2007

16^th International Headache Research Seminar

March 23–25, 2007

Organizers: Jes Olesen, Nabih Ramadan

INNOVATIVE DRUG DEVELOPMENT FOR HEADACHE DISORDERS

UNCONFIRMED PRELIMINARY PROPOSAL

Key note address: From genetics to headache mechanisms and drug development

Session I: Screening Models

a. High throughput preclinical models

b. Low throughput preclinical models

c. Human models

Session II: Trials methodology

a. Towards more pragmatic in– and exclusion criteria

b. Quantitative end points, stricter success criteria, acute vs. prevention trials

c. Novel clinical designs

Session III: NO and spreading depression modulators

a. iNOS as a migraine target

b. nNOS as a migraine target

c. CSD and other cortical waves as migraine targets

d. Tonabersat

Session IV: CGRP and 5-HT modulators

a. Relevance of CGRP to migraine

b. CGRP antagonists for migraine: challenges and promises

c. New 5-HT related targets

Session V: Ion channel modulators and antiepileptics

a. Ion channel strategies for migraine drug targets

b. Katp channels and migraine

c. Novel AEDs

Session VI: Other future targets for headache therapy

a. Glutamate

b. Vanilloids and cannabinoids

c. Protanoids

International Headache Research Seminars

C/o Professor of Neurology

University of Copenhagen, Glostrup Hospital

N39, Ndr. Ringvej 57, 2600 Glostrup, Denmark

Phone: [phone]/ email [e-mail]