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Abstract

Tuberous sclerosis complex 1 (hamartin) is an effective endogenous neuroprotectant. Understanding the endogenous mechanism for neuroprotection mediated by hamartin may afford a novel approach to effective treatment of neurological diseases such as stroke, neurodegenerative diseases, and epilepsy, with possible applications to nonneurological conditions.

Keywords

acute stroke therapy hamartin ischemic stroke neuroprotection productive autophagy treatment

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Endogenous Neuroprotection: Hamartin Modulates an Austere Approach to Staying Alive in a Recession

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