The formation and maintenance of social attachments are fundamental to human biology. Because deficits in the ability to form such attachments are associated with a variety of psychological disorders, an understanding of the neural basis of social attachment may provide insights into the causes of such disorders. Comparative studies using several closely related species of voles that display different social organizations and behaviors have begun to provide important insights into the neurochemical events underlying social attachment. Here we review recent developments in the study of social attachment, focusing on the roles of specific neurochemical systems in pair-bond formation.
CarterC.S.GetzL.L.(1993). Monogamy and the prairie vole. Scientific American, 268, 100–106.
2.
De VriesG.J.BoyleP.A. (1998). Double duty for sex differences in the brain. Behavioral Brain Research, 92, 205–213.
3.
WangZ.YoungL.J.De VriesG.J.InselT.R. (1998). Voles and vasopressin: A review of molecular, cellular, and behavioral studies of pair bonding and paternal behaviors. Progress in Brain Research, 119, 483–499.
4.
YoungL.J.WangZ.InselT.R.(1998). Neuroendocrine bases of monogamy. Trends In Neuroscience, 21, 71–75.
5.
AragonaB.J.LiuY.CurtisJ.T.StephanF.K.WangZ.X. (in press). A critical role for dopamine in pair bonding in male prairie voles. Journal of Neuroscience.
6.
BamshadM.NovakM.A.De VriesG.J. (1993). Sex and species differences in the vasopressin innervation of sexually naive and parental prairie voles, Microtus ochrogaster and Meadow voles, Microtus pennsylvanicus. Journal of Neuroendocrinology, 5, 247–255.
7.
ChoM.M.DeVriesA.C.WilliamsJ.R.CarterC.S. (1999). The effects of oxytocin and vasopressin on partner preferences in male and female prairie voles (Microtus ochrogaster). Behavioral Neuroscience, 113, 1071–1079.
8.
DeVriesA.C.DeVriesM.B.TaymansS.E.CarterC.S. (1996). The effects of stress on social preferences are sexually dimorphic in prairie voles. Proceedings of the National Academy of Sciences, USA, 93, 11980–11984.
9.
FowlerC.D.LiuY.OuimetC.WangZ. (2002). The effects of social environment on adult neurogenesis in the female prairie vole. Journal of Neurobiology, 51, 115–128.
10.
GingrichB.LiuY.CascioC.WangZ.InselT.R. (2000). Dopamine D2 receptors in the nucleus accumbens are important for social attachment in female prairie voles (Microtus ochrogaster). Behavioral Neuroscience, 114, 173–183.
11.
InselT.R.ShapiroL.E. (1992). Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles. Proceedings of the National Academy of Sciences, USA, 89, 5981–5985.
12.
InselT.R.YoungL.J. (2000). Neuropeptides and the evolution of social behavior. Current Opinion in Neurobiology,10, 784–789.
13.
LiuY.CurtisJ.T.WangZ. (2001). Vasopressin in the lateral septum regulates pair bond formation in male prairie voles (Microtus ochrogaster). Behavioral Neuroscience, 115, 910–919.
14.
PitkowL.J.SharerC.A.RenX.InselT.R.TerwilligerE.F.YoungL.J. (2001). Facilitation of affiliation and pair-bond formation by vasopressin receptor gene transfer into the ventral forebrain of a monogamous vole. Journal of Neuroscience, 21, 7392–7396.
15.
WangZ.YoungL.J.LiuY.InselT.R. (1997). Species differences in vasopressin receptor binding are evident early in development: Comparative anatomic studies in prairie and montane voles. Journal of Comparative Neurology, 378, 535–546.
16.
WangZ.YuG.CascioC.LiuY.GingrichB.InselT.R. (1999). Dopamine D2 receptor-mediated regulation of partner preferences in female prairie voles (Microtus ochrogaster): A mechanism for pair bonding?Behavioral Neuroscience,113, 602–611.
17.
WilliamsJ.R.InselT.R.HarbaughC.R.CarterC.S. (1994). Oxytocin administered centrally facilitates formation of a partner preference in female prairie voles (Microtus ochrogaster). Journal of Neuroendocrinology, 6, 247–250.
18.
WinslowJ.T.HastingsN.CarterC.S.HarbaughC.R.InselT.R. (1993). A role for central vasopressin in pair bonding in monogamous prairie voles. Nature, 365, 545–548.
19.
YoungL.J.NilsenR.WaymireK.G.MacGregorG.R.InselT.R. (1999). Increased affiliative response to vasopressin in mice expressing the v1a receptor from a monogamous vole. Nature, 400, 766–768.
20.
YoungL.J.WaymireK.G.NilsenR.MacGregorG.R.WangZ.InselT.R. (1997). The 5' flanking region of the monogamous prairie vole oxytocin receptor gene directs tissue-specific expression in transgenic mice. Annals of the New York Academy of Science, 807, 515–517.
