Abstract
A drug release system based on chitosan and 8-hydroxy-7-iodoquinoline-5-sulfonic acid (SQ), a substance with antimicrobial and antimycotic activity, was developed. Drug loading and release from beads non-crosslinked or crosslinked with glutaraldehyde (GA) and epichlorohydrin (ECC), as well as beads coated with a polyelectrolyte of complex chitosanpoly(2-acryloylamido-2-propane sulfonic acid) under different conditions were compared. SQ was sorbed almost stoichiometrically with respect to the free amino groups in non-crosslinked or crosslinked ECC beads, whereas much higher amounts of SQ were entrapped in the beads crosslinked with GA. The amount of SQ released depended on chitosan crosslinking and pH of the medium, while the release rate of the drug is additionally influenced by drying and coating the beads with a polyelectrolyte complex. The longest period of diffusionally controlled release was observed from dry beads crosslinked with GA at pH 7.
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