Postprandial hyperlipidaemia may be a predictor of vascular risk.
Design
We evaluated postprandial lipaemia after an oral fat tolerance test (OFTT) in men (n = 41) and women (n = 21) with metabolic syndrome (MetS).
Methods
Triglyceride (TG) levels were measured before and 2, 4, 6 and 8 h after the fat load.
Results
Men showed a greater plasma TG response 8 h after the fat load (284 ± 117 versus 224 ± 126 mg/dl, P = 0.029). Only fasting TG levels significantly predicted the TG area under the curve (AUC) and incremental AUC.
Conclusions
Men had a more pronounced postprandial hypertriglyceridaemia and seem to have delayed TG clearance.
GodslandIFWynnVCrookDMillerNE. Sex, plasma lipoproteins, and atherosclerosis: prevailing assumptions and outstanding questions. Am Heart J1987; 114:1467–1503.
2.
CouillardCBergeronNPrud'hommeDBergeronJTremblayABouchardCGender difference in postprandial lipemia: importance of visceral adipose tissue accumulation. Arterioscler Thromb Vasc Biol1999; 19: 2448–2455.
3.
CohnJSMcNamaraJRCohnSDOrdovasJMSchaeferEJ. Postprandial plasma lipoprotein changes in human subjects of different ages. J Lipid Res1988; 29:469–479.
4.
KarpeFSteinerGUffelmanKOlivecronaTHamstenA. Postprandial lipoproteins and the progression of coronary atherosclerosis. Atherosclerosis1994; 106:83–97.
5.
KolovouGAnagnostopoulouKDaskalopoulouSMikhailidisDP. Clinical relevance of postprandial lipaemia. Curr Med Chem2005; 12:1931–1945.
6.
De ManFHCabezasMCVan BarlingenHHErkelensDWde BruinTW. Triglyceride-rich lipoproteins in non-insulin-dependent diabetes mellitus: post-prandial metabolism and relation to premature atherosclerosis. Eur J Clin Invest1996; 26:89–108.
7.
KolovouGDDaskalovaDChIraklianouSAAdamopoulouENPilatisNDHatzigeorgiouGCPostprandial lipemia in hypertension. J Am Coll Nutr2003; 22:80–87.
8.
DuboisCArmandMAzais-BraescoVPortugalHPauliAMBernardPMEffects of moderate amounts of emulsified dietary fat on postprandial lipemia and lipoproteins in normolipidemic adults. Am J Clin Nutr1994; 60:374–382.
9.
CoppackSW. Postprandial lipoproteins in non-insulin-dependent diabetes mellitusDiabet Med1997; 14(suppl 3):S67–74.
10.
ZilversmitDB. Atherogenesis: a postprandial phenomenon. Circulation1979; 60:473–485.
11.
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults.Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA2001; 285:2486–2497.
12.
KolovouGDAnagnostopoulouKKPilatisNKafaltisNSorodilaKPsarrosELow fasting low high-density lipoprotein and postprandial lipemia. Lipids Health Dis2004; 3:18.
13.
CouillardCBergeronNBergeronJPascotAMauriegePTremblayAMetabolic heterogeneity underlying postprandial lipemia among men with low fasting high density lipoprotein cholesterol concentrations. J Clin Endocrinol Metab2000; 85:4575–4582.
14.
FreemanDJCaslakeMJGriffinBAHinnieJTanCEWatsonTDThe effect of smoking on post-heparin lipoprotein and hepatic lipase, cholesteryl ester transfer protein and lecithin:cholesterol acyl transferase activities in human plasma. Eur J Clin Invest1998; 28: 584–591.
15.
LamarchBRashidSLewisGF. HDL metabolism in hypertriglyceridemic states: an overview. Clin Chim Acta1999; 286:145–161.
16.
DespresJPAllardCTremblayATalbotJBouchardC. Evidence for a regional component of body fatness in the association with serum lipids in men and women. Metabolism1985; 34:967–973.
17.
ChanDCWattsGFBarrettPHO'NeillFHRedgraveTGThompsonGR. Relationships between cholesterol homoeostasis and triacylglycerol-rich lipoprotein remnant metabolism in the metabolic syndrome. Clin Sci (Lond)2003; 104:383–388.
18.
HaffnerSMMykkanenLFestaABurkeJPSternMP. Insulin-resistant prediabetic subjects have more atherogenic risk factors than insulin-sensitive prediabetic subjects. Implications for preventing coronary heart disease during the prediabetic state. Circulation2000; 101:975–980.
19.
LansingMCWilliamsGHCarrollJS. Correlation between the glucose clamp technique and the homeostasis model assessment in hypertension. Am J Hypertens2002; 14:51–53.
20.
KatzANambiSSMatherKBaronADFollmannDASullivanGQuantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab2000; 85:2402–2410.
21.
HrebicekJJanoutVMalincikovaJHorakovaDCizekL. Detection of insulin resistance by simple quantitative insulin sensitivity check index QUICKI for epidemiological assessment and prevention. J Cin Endocrinol Metab2002; 87:144–147.
22.
HostmarkATBergJBrudalSBergeSRKierulfPBjerkedalT. Coronary risk factors in middle-aged men as related to smoking, coffee intake and physical activity. Scand J Soc Med1992; 20:196–203.
23.
AxelsenMEliassonBJoheimELennerRATaskinenMRSmithU. Lipid intolerance in smokers. J Intern Med1995; 237:449–455.
24.
ZaratinACBertolamiMCFaludiAARochaJCNunesVSNakandakareERAcute in vivo chylomicron metabolism and postalimentary lipoprotein alterations in normolipidemic male smokers. Clin Chim Acta2001; 305:99–105.
