Earlier we showed cardiac isoform of α-2 macroglobulin (CA2M) to be an early marker of cardiac hypertrophy.
Design
In this study, we tried to explore the possibility of using this protein as a marker for diagnosis of cardiac diseases.
Methods
A total of 593 samples were analyzed for the presence of CA2M using sandwich enzyme-linked immunosorbent assay.
Results
Samples include various cardiac diseases (230), non-cardiac ailments (263) and controls (100).
Conclusion
Levels of CA2M in cardiac diseases were significantly higher than other sample groups but moderately elevated in leprosy. This protein could be considered for diagnosis of cardiac diseases as a serum marker.
World Health Organization. World Health Report.Geneva: World Health Organization; 2003.
2.
McCulloughPANowakRMMcCordJHollanderJEHerrmannHCStegPG, et al. B-type natriuretic peptide and clinical judgement in emergency diagnosis of heart failure.Circulation2002; 106:416–422.
3.
RajamanickamCSakthivelSJegadeesh BabuGLottspeichFKadenbachB.Cardiac isoform of α-2 macroglobin, a novel serum protein, may induce cardiac hypertrophy in rats.Basic Res Cardiol2001; 96:23–33.
4.
RajamanickamCSakthivelSJosephPKJanarthananRA.A novel serum protein of molecular weight 182 kDa: a molecular marker for an early detection of increased left ventricular mass in patients with cardiac hypertrophy.J Cardiovasc Risk1998; 5:335–338.
5.
RajanSRadhakrishnanJChellam RajamanickamC.Direct injection and expression in vivo of full-length cDNA of the cardiac isoform of alpha-2 macroglobulin induces cardiac hypertrophy in the rat heart.Basic Res Cardiol2003; 98:39–49.
6.
MeenakshiSThirunavukkarasuCRajamaickamC.Effect of cytosol on transport of RNA in vitro during cardiac hypertrophyBiochem J 183; 209:285–290.
7.
KatochK.Cardiovascular involvement in leprosy. In: Proceedings of XII Biennial Conference of the Indian Association of Leprologists; 9–12 September 1981; Bombay, India, pp. 129.
8.
MathurSMItigiAVeniKRaoD.Congestive heart failure in two patients of leprosy.Lepr India1976; 48:75–77.
9.
ZawarPBChawhanRNSwamiRM.Electrocardiographic changes in lepra reaction.Lepr India1983; 55:197–199.
10.
KatochKRamuG.Cardiovascular involvement in leprosy patient.Japan J Lepr1983; 52:73–81.
11.
YajimaMNaritaM.Pathology of the heart and blood vessels in Hansen's disease [in Japanese].Nihon Hansenbyo Gakkai Zasshi1997; 66:109–118.
12.
ShahPKDMalhotraYKLakhotiaMKothariAJainSKMehtaS.Cardiovascular dysautonomia in patients with lepromatous leprosy.Indian J Lepr1990; 62:91–97.
13.
KatochK.Leprosy. Systemic aspects. In: WaliaRG editor: IADVL textbook and atlas of dermatology.Bombay: Bhalani Publishing House; 1994, pp. 1372–1385.
14.
MitraSGombarKKGombarS.Anaesthetic considerations in a patient with lepromatous leprosy.Can J Anaesth1998; 45:1103–1105.
