Biomonitoring of Industrial Pollutants: Health and Policy Implications of the Chemical Body Burden

Centers for Disease Control and Prevention (US). National report on human exposure to environmental chemicals. Atlanta: CDC; 2001. Also available from: URL: http://www.cdc.gov/nceh/dls/report/PDF/CompleteReport.pdf [cited 2002 Oct 3].

Environmental Protection Agency (US). Master testing list. EPA Office of Pollution Prevention and Toxics; 2001. Also available from: URL: www.epa.gov/opptintr/chemtest/mtl.htm [cited 2002 Oct 3].

Roe D Pease W Florini K Silbergeld E Leiserson K Below C , Toxic ignorance: The continuing absence of basic health testing for top-selling chemicals in the United States. New York: Environmental Defense Fund; 1997. Also available from: URL: http://www.environmentaldefense.org/documents/243_toxicignorance.pdf [cited 2002 Oct 3].

Zeeman M Smrchek J Nabholz J Rodier D . US EPA/OPPT and sediments: Screening new and existing chemicals for potential environmental effects. Washington: Environmental Protection Agency Office of Pollution Prevention and Toxics (US); 1996. Also available from: URL: http://www.epa.gov/waterscience/cs/zeeman.pdf [cited 2002 Oct 3].

Loganathan BG Kannan K . Global organochlorine contamination trends: An overview. Ambio 1994; 23:187–91.

Simonich SL Hites RA . Global distribution of persistent organochlorine compounds. Science 1995; 269:1851–4.

Wu C Schaum J . Exposure assessment of trichloroethylene. Environ Health Perspect 2000;108 Suppl 2:359–63.

Environmental Protection Agency (US), National Center for Environmental Assessment. Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and Related Compounds, Part III (SAB Review Draft). Washington (DC); 2000.

Hill RH Jr Ashley DL Head SL Needham LL Pirkle JL . p-Dichlorobenzene exposure among 1,000 adults in the United States. Arch Environ Health 1995; 50:277–80.

Zartarian VG Ozkaynak H Burke JM Zufall MJ Rigas ML Furtaw EJ Jr. , A modeling framework for estimating children's residential exposure and dose to chlorpyrifos via dermal residue contact and nondietary ingestion. Environ Health Perspect 2000; 108:505–14.

Klaassen CD , editor. Casarett & Doull's toxicology: The basic science of poisons. 5th ed. New York: McGraw-Hill; 1996.

Lippman M , editor. Environmental toxicants: Human exposures and their health effects. 2nd ed. New York: Wiley Interscience; 2000.

Agency for Toxic Substances and Disease Registry. Toxicological Profile Series, Washington (DC): US Public Health Service; 1989 −1999.

National Research Council (US), Committee on National Monitoring of Human Tissues. Monitoring human tissues for toxic substances. Washington: National Academy Press 1991.

Landrigan PJ . Relation of body burden measures to ambient measures. In: Gordish S , editor. Epidemiology and health risk assessment. New York: Oxford University Press; 1988.

Onstot J Ayling R Stanley J . Characterization of HRGC/MS unidentified peaks from the analysis of human adipose tissue. Volume 1: Technical approach. Washington (DC): US Environmental Protection Agency Office of Toxic Substances (560/6-87-002a); 1987.

Wolff MS Schecter A . Accidental exposure of children to polychlorinated biphenyls. Arch Environ Contam Toxicol 1991; 20:449–53.

Brock JW Melnyk LJ Caudill SP Needham LL Bond AR . Serum levels of several organochlorine pesticides in farmers correspond with dietary exposure and local use history. Toxicol Ind Health 1998; 14:275–89.

Beck H Eckart K Mathar W Wittkowski L . Levels of PCDD's and PCDF's in adipose tissue of occupationally exposed workers. Chemosphere 1989; 18:507–16.

Schecter A Papke O Ball M Lis A Brandt-Rauf P . Dioxin concentrations in the blood of workers at municipal waste incinerators. Occup Environ Med 1995; 52:385–7.

Kang HK Watanabe KK Breen J Remmers J Conomos MG Stanley J Flicker M . Dioxins and dibenzofurans in adipose tissue of US Vietnam veterans and controls. Am J Public Health 1991; 81:344–9.

Ryan JJ Schecter A Masuda Y Kikuchi M . Comparison of PCDDS and PCDFs in the tissue of Yusho patients with those from the general population in Japan and China. Chemosphere 1987; 16:2017–25.

Thornton J . Pandora's poison: Chlorine, health and a new environmental strategy. Cambridge: MIT Press; 2000.

Murphy R Harvey C . Residues and metabolites of selected persistent halogenated hydrocarbons in blood specimens from a general population survey. Environ Health Perspect 1985; 60:115–20.

Savage E Keefe TJ Tessari JD Wheeler HW Applehans FM Goes EA , National study of chlorinated hydrocarbon insecticide residues in human milk, USA. I. Geographic distribution of dieldrin, heptachlor, heptachlor epoxide, chlordane, oxychlordane, and mirex. Am J Epidemiol 1981; 113:413–22.

Orban JE Stanley JS Schwemberger JG Remmers JC . Dioxins and dibenzofurans in adipose tissue of the general US population and selected subpopulations. Am J Public Health 1994; 84:439–45.

Wallace LA Pellizzari E Hartwell T Rosenzweig M Erickson M Sparacino C Zelon H . Personal exposure to volatile organic compounds. I. Direct measurements in breathing-zone air, drinking water, food, and exhaled breath. Environ Res 1984; 35:293–319.

Wallace LA Pellizzari ED Hartwell TD Whitmore R Zelon H Perritt R , The California TEAM study: Breath concentrations and personal exposures to 26 volatile compounds in air and drinking water of 188 residents of Los Angeles, Antioch, and Pittsburg, CA. Atmos Environ 1988; 22:2141–63.

Pellizzari ED Hartwell TD Harris BS Waddell RD Whitaker DA Erickson MD . Purgeable organic compounds in mother's milk. Bull Environ Contam Toxicol 1982: 28:322–8.

Pirkle JL Needham LL Sexton K . Improving exposure assessment by monitoring human tissues for toxic chemicals. J Expo Anal Environ Epidemiol 1995; 5:405–24.

Paschal DC Ting BG Morrow JC Pirkle JL Jackson RJ Sampson EJ , Trace metals in urine of United States residents: Reference range concentrations. Environ Res 1998; 76:53–9.

Needham LL Hill RH Ashley DL Pirkle JL Sampson EJ . The priority toxicant reference range study: Interim report. Environ Health Perspect 1995;103 Suppl 3:89–94.

Needham LL Patterson DG Jr Burse VW Paschal DC Turner WE Hill RH Jr. , Reference range data for assessing exposure to selected environmental toxicants. Toxicol Ind Health 1996; 12:507–13.

Ligon WV Dorn SB May RJ . Chlorodibenzofuran and chlorodibenzo-p-dioxin levels in Chilean mummies dated to about 2800 years before the present. Environ Sci Technol 1989; 23:1286–90.

Tong HY Gross MLO Schecter A Monson SJ Dekin A . Sources of dioxin in the environment: Second stage study of PCDD/Fs in ancient human tissue and environmental samples. Chemosphere 1990; 20:987–92.

Robinson PE Mack GA Remmers J Levy R Mohadjer L . Trends of PCB, hexachlorobenzene, and betabenzene hexachloride levels in the adipose tissue of the U.S. population. Environ Res 1990; 53:175–92.

Kutz FW Wood PH Bottimore DP . Organochlorine pesticides and polychlorinated biphenyls in human adipose tissue. Rev Environ Contam Toxicol 1991; 120:1–82.

Mes J . Temporal changes in some chlorinated hydrocarbon residue levels of Canadian breast milk and infant exposure. Environ Pollution 1994; 84:261–8.

LaKind JS Berlin CM Naiman DQ . Infant exposure to chemicals in breast milk in the United States: What we need to learn from a breast milk monitoring program. Environ Health Perspect 2001; 109:75–88.

Anderson HA Wolff MS . Environmental contaminants in human milk. J Expo Anal Environ Epidemiol 2000; 10:755–60.

Committee on Hormonally Active Agents in the Environment, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council (US). Hormonally active agents in the environment. Washington: National Academy Press 1999.

Berkowitz GS Wolff MS Matte T Susser E Landrigan PJ . The rationale for a national prospective cohort study of environmental exposure and childhood development. Environ Res 2001; 85(2):59–68.

Anderson LM Beebe LE Fox SD Issaq HJ Kovatch RM . Promotion of mouse lung tumors by bioaccumulated polychlorinated aromatic hydrocarbons. Exp Lung Res 1991; 17:455–71.

National Research Council (US). Committee on Pesticides in the Diets of Infants and Children. Pesticides in the diets of infants and children. Washington: National Academy Press; 1993.

Lanphear BP Dietrich K Auinger P Cox C . Cognitive deficits associated with blood lead concentrations <10 microg/dL in US children and adolescents. Public Health Rep 2000; 115:521–9.

Gray LE Jr Kelce WR Monosson E Ostby JS Birnbaum LS . Exposure to TCDD during development permanently alters reproductive function in male Long Evans rats and hamsters: Reduced ejaculated and epididymal sperm numbers and sex accessory gland weights in offspring with normal androgenic status. Toxicol Appl Pharmacol 1995; 131:108–18.

Howdeshell KL Hotchkiss AK Thayer KA Vandenbergh JG vom Saal FS . Exposure to bisphenol A advances puberty. Nature 1999; 401:763–4.

Axelrod D Davis DL Hajek RA Jones LA . It's time to rethink dose: The case for combining cancer and birth and developmental defects. Environ Health Perspect 2001; 109:A246–9.

Sheehan DM Willingham E Gaylor D Bergeron JM Crews D . No threshold dose for estradiol-induced sex reversal of turtle embryos: How little is too much? Environ Health Perspect 1999; 107:155–9.

Rose G . Environmental factors and disease: The man made environment. Br Med J 1987; 294:963–5.

DeVito MJ Birnbaum LS Farland WH Gasiewicz TA . Comparisons of estimated human body burdens of dioxinlike chemicals and TCDD body burdens in experimentally exposed animals. Environ Health Perspect 1995; 103:820–31.

Gray LE Ostby JS Kelce WR . A dose-response analysis of the reproductive effects of a single gestational dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male Long Evans hooded rat offspring. Toxicol Appl Pharmacol 1997; 146:11–20.

Ulrich EM Caperell-Grant A Jung S Hites RA Bigsby RM . Environmentally relevant xenoestrogen tissue concentrations correlated to biological responses in mice. Environ Health Perspect 2000; 108:973–7.

Seegal RF Schantz SL . Neurochemical and behavioral sequelae of exposure to dioxins and PCBs. In: Schecter A , editor. Dioxins and health. New York: Plenum Press; 1994. p. 409–48.

Markowski VP Zareba G Stern S Cox C Weiss B . Altered operant responding for motor reinforcement and the determination of benchmark doses following perinatal exposure to low-level 2,3,7,8-tetrachlorodibenzo-p-dioxin. Environ Health Perspect 2001; 109:621–7.

Giesy JP Ludwig JP Tillitt DJ . Dioxins, dibenzofurans, PCBs and wildlife. In: Schecter A , editor. Dioxins and health. New York: Plenum Press; 1994. p. 249–308.

White DH Seginak JT . Dioxins and furans linked to reproductive impairment in wood ducks. J Wildlife Manage 1994; 58:100–6.

Jacobson JL Jacobson SW . Intellectual impairment in children exposed to polychlorinated biphenyls in utero. N Engl J Med 1996; 335:783–9.

Rogan WJ Gladen BC . PCBs, DDE, and child development at 18 and 24 months. Ann Epidemiol 1991; 1:407–13.

Koopman-Esseboom C Weisglas-Kuperus N de Ridder MA Van der Paauw CG Tuinstra LG Sauer PJ . Effects of polychlorinated biphenyl/dioxin exposure and feeding type on infants’ mental and psychomotor development. Pediatrics 1996; 97:700–6.

Patandin S Lanting CI Mulder PG Boersma ER Sauer PJ Weisglas-Kuperus N . Effects of environmental exposure to polychlorinated biphenyls and dioxins on cognitive abilities in Dutch children at 42 months of age. J Pediatr 1999; 134:33–41.

Weisglas-Kuperus N Patandin S Berbers GA Sas TC Mulder PG Sauer PJ , Immunologic effects of background exposure to polychlorinated biphenyls and dioxins in Dutch preschool children. Environ Health Perspect. 2000; 108:1203–7.

Koopman-Esseboom C Morse DC Weisglas-Kuperus N Lutkeschipholt IJ Van der Paauw CG Tuinstra LG , Effects of dioxins and polychlorinated biphenyls on thyroid hormone status of pregnant women and their infants. Pediatr Res 1994; 36:468–73.

Committee on New Guidelines on Chemicals Policy. Non-hazardous products. Stockholm: Swedish Ministry of the Environment; 2000.

European Parliament, Resolution on the Commission White Paper on Strategy for a Future Chemicals Policy [COM(2001) 88-C5-0258/2001-2001/2118(COS)]. Minutes of 2001 Nov 15; Provisional Edition. Brussels: European Parliament.

Juberg DR . Traces of environmental chemicals in the human body: Are they a risk to health? Washington: American Council on Science and Health, April 1999; p. 1–15.

Raffensperger C Tickner J , editors. Protecting public health and the environment: Implementing the precautionary principle. Washington: Island Press, 1999.

Van den Berg M Birnbaum L Bosveld AT Brunstrom B Cook P Feeley M , Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and for wildlife. Environ Health Perspect 1998; 106:775–92.