References

AAPM (1986). American Association of Physicists in Medicine. Protocol for Heavy Charged-Particle Therapy Beam Dosimetry. AAPM Report 16 (American Association of Physicists in Medicine, New York).

Ableitinger A. , Vatnitsky S. , Herrmann R. , Bassler N. , Palmans H. , Sharpe P. , Ecker S. , Chaudhri N. , Jäkel O. , and Georg D. (2013). ‘Dosimetry auditing procedure with alanine dosimeters for light ion beam therapy,’ Radiother. Oncol. 108, 99–106.

Acharya S. , Fischer-Valuck B.W. , Kashani R. , Parikh P. , Yang D. , Zhao T. , Green O. , Wooten O. , Li H.H. , Hu Y. , Rodriguez V. , Olsen L. , Robinson C. , Michalski J. , Mutic S. , and Olsen J. (2016). ‘Online magnetic resonance image guided adaptive radiation therapy: first clinical applications,’ Int. J. Radiat. Oncol. Biol. Phys. 94, 394–403.

Albertini F. , Bolsi A. , Lomax A.J. , Rutz H.P. , Timmerman B. , and Goitein G. (2008). ‘Sensitivity of intensity modulated proton therapy plans to changes in patient weight,’ Radiother. Oncol. 86, 187–194.

Albertini F. , Hug E.B. , and Lomax A.J. (2011). ‘Is it necessary to plan with safety margins for actively scanned proton therapy?,’ Phys. Med. Biol. 56, 4399.

Allison J. , Amako K. , Apostolakis J. , Araujo H. , Dubois P.A. , Asai M. , Barrand G. , Capra R. , Chauvie S. , Chytracek R. , Cirrone G.A.P. , Cooperman G. , Cosmo G. , Cuttone G. , Daquino G.G. , Donszelmann M. , Dressel M. , Folger G. , Foppiano F. , Generowicz J. , Grichine V. , Guatelli S. , Gumplinger P. , Heikkinen A. , Hrivnacova I. , Howard A. , Incerti S. , Ivanchenko V. , Johnson T. , Jones F. , Koi T. , Kokoulin R. , Kossov M. , Kurashige H. , Lara V. , Larsson S. , Lei F. , Link O. , Longo F. , Maire M. , Mantero A. , Mascialino B. , Mclaren I. , Lorenzo P.M. , Minamimoto K. , Murakami K. , Nieminen P. , Pandola L. , Parlati S. , Peralta L. , Perl J. , Pfeiffer A. , Pia M.G. , Ribon A. , Rodrigues P. , Russo G. , Sadilov S. , Santin G. , Sasaki T. , Smith D. , Starkov N. , Tanaka S. , Tcherniaev E. , Tome B. , Trindade A. , Truscott P. , Urban L. , Verderi M. , Walkden A. , Wellisch J.P. , Williams D.C. , Wright D. and Yoshida H. (2006). ‘Geant4 developments and applications,’ IEEE Trans. Nucl. Sci. 53, 270–278.

Alrowaili Z.A. , Lerch M.L.F. , Petasecca M. , Carolan M.G. , Metcalfe P.E. , and Rosenfeld A.B. (2016). ‘Beam perturbation characteristics of a 2D transmission silicon diode array, magic plate,’ J. Appl. Clin. Med. Phys. 17, 85–98.

Amaldi U. , and Kraft G. (2009). ‘Hadrontherapy: Cancer treatment with proton and carbon beams,’ pp. 165–171 in Radiotherapy and Brachytherapy, Lemoigne Y. , and Caner A. , Eds. (Springer, New York).

Amin M.B. , Greene F.L. , Edge S.B. , Compton C.C. , Gershenwald J.E. , Brookland R.K. , Meyer L. , Gress D.M. , Byrd D.R. , and Winchester D.P. (2017). ‘The Eighth Edition AJCC Cancer Staging Manual: continuing to build a bridge from a population-based to a more “personalized” approach to cancer staging,’ CA Cancer J. Clin. 67, 93–99.

Ammazzalorso F. , Jelen U. , Engenhart-Cabillic R. , and Schlegel W. (2014). ‘Dosimetric robustness against setup errors in charged particle radiotherapy of skull base tumors,’ Radiat. Oncol. 9, 279.

Anderle K. , Stroom J. , Pimentel N. , Greco C. , Durante M. , and Graeff C. (2016). ‘In silico comparison of photons versus carbon ions in single fraction therapy of lung cancer,’ Phys. Med. 32, 1118–1123.

Andreo P. (2009). ‘On the clinical spatial resolution achievable with protons and heavier charged particle radiotherapy beams,’ Phys. Med. Biol. 54, N205–N215.

Andreo P. , Wulff J. , Burns D.T. , Palmans H. (2013). ‘Consistency in reference radiotherapy dosimetry: resolution of an apparent conundrum when ⁶⁰Co is the reference quality for charged-particle and photon beams,’ Phys. Med. Biol. 58, 6593–6621.

Archambeau J.O. , Bennett G.W. , Levine G.S. , Cowen R. , and Akanuma A. (1974). ‘Proton radiation therapy,’ Radiology 110, 445–457.

Arjomandy B. , Sahoo N. , Zhu X.R. , Zullo J.R. , Wu R.Y. , Zhu M.P. , Ding X.N. , Martin C. , Ciangaru G. , and Gillin M.T. (2009). ‘An overview of the comprehensive proton therapy machine quality assurance procedures implemented at The University of Texas M. D. Anderson Cancer Center Proton Therapy Center-Houston,’ Med. Phys. 36, 2269–2282.

Arjomandy B. , Taylor P. , Ainsley C. , Safai S. , Sahoo N. , Pankuch M. , Farr J.B. , Park S.Y. , Klein E. , Flanz J. , and Yorke E.D. (2019). ‘AAPM task group 224: Comprehensive proton therapy machine quality assurance,’ Med. Phys. 46, e678–e705.

Badano L. , Crescenti M. , Holy P. , Maier A.T. , Knaus P. , Bryant P.J. , Benedikt M. , Pullia M. , and Rossi S. (1999). Proton-Ion Medical Machine Study (PIMMS), Part 1, CERN PS-99-010-D1(CERN, Geneva).

Baek H.J. , Kim T.H. , Shin D.H. , Kwak J.W. , Choo D.W. , Lee S.B. , Furusawa Y. , Ando K. , Kim S.S. , and Cho K.H. (2008). ‘Radiobiological characterization of proton beam at the National Cancer Center in Korea,’ J. Radiat. Res. Oncol. Biol. Phys. 49, 509–515.

Balter J.M. , Lam K.L. , McGinn C.J. , Lawrence T.S. , and Ten Haken R.K. (1998). ‘Improvement of CT-based treatment-planning models of abdominal targets using static exhale imaging,’ Int. J. Radiat. Oncol. Biol. Phys. 41, 939–943.

Balter J.M. , Wright J.N. , Newell L.J. , Friemel B. , Dimmer S. , Cheng Y. , Wong J. , Vertatschitsch E. , and Mate T.P. (2005). ‘Accuracy of a wireless localization system for radiotherapy,’ Int. J. Radiat. Oncol. Biol. Phys. 61, 933–937.

Bassler N. , Jäkel O. , Søndergaard C.S. , and Petersen J.B. (2010). ‘Dose-and LET-painting with particle therapy,’ Acta Oncol. 49, 1170–1176.

Bassler N. , Toftegaard J. , Luhr A. , Sorensen B.S. , Scifoni E. , Kramer M. , Jäkel O. , Mortensen L.S. , Overgaard J. , and Petersen J.B. (2014). ‘LET-painting increases tumour control probability in hypoxic tumours,’ Acta Oncol. 53, 25–32.

Battistoni G. , Bauer J. , Boehlen T.T. , Cerutti F. , Chin M.P. , Dos Santos Augusto R. , Ferrari A. , Ortega P.G. , Kozlowska W. , Magro G. , Mairani A. , Parodi K. , Sala P.R. , Schoofs P. , Tessonnier T. , and Vlachoudis V. (2016). ‘The FLUKA Code: an accurate simulation tool for particle therapy,’ Front. Oncol. 6, 116.

Bauer J. , Unholtz D. , Sommerer F. , Kurz C. , Haberer T. , Herfarth K. , Welzel T. , Combs S.E. , Debus J. , and Parodi K. (2013). ‘Implementation and initial clinical experience of offline PET/CT-based verification of scanned carbon ion treatment,’ Radiother. Oncol. 107, 218–226.

Baum C. , Alber M. , Birkner M. , and Nusslin F. (2006). ‘Robust treatment planning for intensity modulated radiotherapy of prostate cancer based on coverage probabilities,’ Radiother. Oncol. 78, 27–35.

Bäumer C. , Ackermann B. , Hillbrand M. , Kaiser F.J. , Koska B. , Latzel H. , Luhr A. , Menkel S. , and Timmermann B. (2016). ‘Dosimetry intercomparison of four proton therapy institutions in Germany employing spot scanning,’ Z. Med. Phys. 27, 80–85.

Beadle B.M. , Jhingran A. , Salehpour M. , Sam M. , Iyer R.B. , and Eifel P.J. (2009). ‘Cervix regression and motion during the course of external beam chemoradiation for cervical cancer,’ Int. J. Radiat. Oncol. Biol. Phys. 73, 235–241.

Bechtold A. , Schempp A. , Ratzinger U. , and Schlitt B. (2000). ‘Development of an RFQ-injector for a therapy-synchrotron,’ pp. 2500 to 2502 in EPAC 2000: Seventh European Accelerator Conference, Vienna 26 to 30 June 2000 (CERN, Geneva).

Benedict S.H. , Bova F.J. , Clark B. , Goetsch S.J. , Hinson W.H. , Leavitt D.D. , Schlesinger D.J. , and Yenice K.M. (2008). ‘Anniversary paper: The role of medical physicists in developing stereotactic radiosurgery,’ Med. Phys. 35, 4262–4277.

Bentefour el H. , Both S. , Tang S. , and Lu H.M. (2015). ‘Using CBCT for pretreatment range check in proton therapy: a phantom study for prostate treatment by anterior-posterior beam,’ J. Appl. Clin. Med. Phys. 16, 5212.

Bentzen S.M. , Dörr W. , Gahbauer R. , Howell R.W. , Joiner M.C. , Jones B. , Jones D.T. , van der Kogel A.J. , Wambersie A. , and Whitmore G. (2012). ‘Bioeffect modeling and equieffective dose concepts in radiation oncology–terminology, quantities and units,’ Radiother. Oncol. 105, 266–268.

Bert C. , and Durante M. (2011). ‘Motion in radiotherapy: particle therapy,’ Phys. Med. Biol. 56, R113–R144.

Bert C. , and Rietzel E. (2007). ‘4D treatment planning for scanned ion beams,’ Radiat. Oncol. 2, 24.

Bert C. , Saito N. , Schmidt A. , Chaudhri N. , Schardt D. , and Rietzel E. (2007). ‘Target motion tracking with a scanned particle beam,’ Med. Phys. 34, 4768–4771.

Bert C. , Grozinger S.O. , and Rietzel E. (2008). ‘Quantification of interplay effects of scanned particle beams and moving targets,’ Phys. Med. Biol. 53, 2253–2265.

Bert C. , Gemmel A. , Saito N. , and Rietzel E. (2009). ‘Gated irradiation with scanned particle beams,’ Int. J. Radiat. Oncol. Biol. Phys. 73, 1270–1275.

Bert C. , Gemmel A. , Saito N. , Chaudhri N. , Schardt D. , Durante M. , Kraft G. , and Rietzel E. (2010). ‘Dosimetric precision of an ion beam tracking system,’ Radiat. Oncol. 5, 61.

Bert C. , Graeff C. , Riboldi M. , Nill S. , Baroni G. , and Knopf A.C. (2014). ‘Advances in 4D treatment planning for scanned particle beam therapy - report of dedicated workshops,’ Technol. Cancer Res. Treat. 13, 485–495.

Bertero L. , Massa F. , Metovic J. , Zanetti R. , Castellano I. , Ricardi U. , Papotti M. , and Cassoni P. (2017). ‘Eighth Edition of the UICC classification of malignant tumours: an overview of the changes in the pathological TNM classification criteria – what has changed and why?,’ Virchows Arch. 472, 519–531.

Bichsel H. , and Hiraoka T. (1992). ‘Energy-loss of 70 MeV protons in elements,’ Nucl. Instrum. Methods Phys. Res. B 66, 345–351.

BIPM (2006). Bureau International des Poids etMesures. The International System of Units 91 (SI). (Bureau International des Poids etMesures, Sèvres Cedex, France).

Blakely E.A. , Tobias C.A. , Yang T.C. , Smith K.C. , and Lyman J.T. (1979). ‘Inactivation of human kidney cells by high-energy monoenergetic heavy-ion beams,’ Radiat. Res. 80, 122–160.

Blakely E.A. , Ngo F.Q.H. , Curtis S.B. , and Tobias C.A. (1984). ‘Heavy-ion radiobiology – cellular studies,’ Adv. Radiat. Biol. 11, 295–389.

Blakely E. , Tobias C. , Ludewigt B. , and Chu W. (1987). ‘Some physical and biological properties of light ions,’ pp. 19 to 41 in Proc. 5th PTOG Meeting and International Workshop on Biomeidal Accelerators, LBL-22962 (National Technical Information Service, Springfield, Virginia).

Böhlen T.T. , Brons S. , Dosanjh M. , Ferrari A. , Fossati P. , Haberer T. , Patera V. , and Mairani A. (2012). ‘Investigating the robustness of ion beam therapy treatment plans to uncertainties in biological treatment parameters,’ Phys. Med. Biol. 57, 7983–8004.

Bohm D. , and Foldy L.L. (1947). ‘Theory of the synchro-cyclotron,’ Phys. Rev. 72, 649–661.

Bolsi A. , Lomax A.J. , Pedroni E. , Goitein G. , and Hug E. (2008). ‘Experiences at the Paul Scherrer Institute with a remote patient positioning procedure for high-throughput proton radiation therapy,’ Int. J. Radiat. Oncol. Biol. Phys. 71, 1581–1590.

Bortfeld T. , Jokivarsi K. , Goitein M. , Kung J. , and Jiang S.B. (2002). ‘Effects of intra-fraction motion on IMRT dose delivery: statistical analysis and simulation,’ Phys. Med. Biol. 47, 2203–2220.

Bortfeld T. , Jiang S.B. , and Rietzel E. (2004). ‘Effects of motion on the total dose distribution,’ Semin. Radiat. Oncol. 14, 41–51.

Bouchet L.G. , Meeks S.L. , Goodchild G. , Bova F.J. , Buatti J.M. , and Friedman W.A. (2001). ‘Calibration of three-dimensional ultrasound images for image-guided radiation therapy,’ Phys. Med. Biol. 46, 559–577.

Bragg W.H. , and Kleeman R. (1904). ‘LXXIV. On the ionization curves of radium,’ Lond. Edinb. Dubl. Phil. Mag. J. Sci. 8, 726–738.

Brede H.J. , Greif K.D. , Hecker O. , Heeg P. , Heese J. , Jones D.T. , Kluge H. , and Schardt D. (2006). ‘Absorbed dose to water determination with ionization chamber dosimetry and calorimetry in restricted neutron, photon, proton and heavy-ion radiation fields,’ Phys. Med. Biol. 51, 3667–3682.

Brevet R. , Richter D. , Graeff C. , Durante M. , and Bert C. (2015). ‘Treatment parameters optimization to compensate for interfractional anatomy variability and intrafractional tumor motion,’ Front. Oncol. 5, 291.

Brierley J.D. , Gospodarowicz M.K. , and Wittekind C. (2017). TNM Classification of Malignant Tumours, 8th ed. (John Wiley & Sons, Hoboken, New Jersey).

Brock K.K. , Dawson L.A. , Sharpe M.B. , Moseley D.J. , and Jaffray D.A. (2006). ‘Feasibility of a novel deformable image registration technique to facilitate classification, targeting, and monitoring of tumor and normal tissue,’ Int. J. Radiat. Oncol. Biol. Phys. 64, 1245–1254.

Brusasco C. , Voss B. , Schardt D. , Kramer M. , and Kraft G. (2000). ‘A dosimetry system for fast measurement of 3D depth-dose profiles in charged-particle tumor therapy with scanning techniques,’ Nucl. Instrum. Methods Phys. Res. B 168, 578–592.

Bryant P.J. , Weisser L. , Badano L. , Borri G. , Crescenti M. , Holy P. , Reimoser S. , Maier A.T. , Knaus P. , and Pavlovic M. (2000). Proton-Ion Medical Machine Study (PIMMS), Part 2, CERN/PS 2000-007 (CERN, Geneva).

Burigo L. , Greilich S. (2019). ‘Imapct of new ICRU 90 key data on stopping-power ratios and beam quality correction factors for carbon ion beams,’ Phys. Med. Biol. 64: 195005.

Cabal G.A. , and Jäkel O. (2013). ‘Dynamic target definition: a novel approach for PTV definition in ion beam therapy,’ Radiother. Oncol. 107, 227–233.

Cantone M.C. , Ciocca M. , Dionisi F. , Fossati P. , Lorentini S. , Krengli M. , Molinelli S. , Orecchia R. , Schwarz M. , Veronese I. , and Vitolo V. (2013). ‘Application of failure mode and effects analysis to treatment planning in scanned proton beam radiotherapy,’ Radiat. Oncol. 8, 127.

Cao W. , Lim G.J. , Lee A. , Li Y. , Liu W. , Ronald Zhu X. , and Zhang X. (2012). ‘Uncertainty incorporated beam angle optimization for IMPT treatment planning,’ Med. Phys. 39, 5248–5256.

Capote Noy R. , and Vatnitskiy S. (2007). Summary Report of Consultants’ Meeting on Nuclear Data of Charged-Particle Interactions for Medical Therapy Applications, INDC(NDS)-0504 (International Atomic Energy Agency, Geneva).

Carroll P.R. , Parsons J.K. , Andriole G. , Bahnson R.R. , Castle E.P. , Catalona W.J. , Dahl D.M. , Davis J.W. , Epstein J.I. , Etzioni R.B. , Farrington T. , Hemstreet G.P. III , Kawachi M.H. , Kim S. , Lange P.H. , Loughlin K.R. , Lowrance W. , Maroni P. , Mohler J. , Morgan T.M. , Moses K.A. , Nadler R.B. , Poch M. , Scales C. , Shaneyfelt T.M. , Smaldone M.C. , Sonn G. , Sprenkle P. , Vickers A.J. , Wake R. , Shead D.A. , and Freedman-Cass D.A. (2016). ‘NCCN guidelines insights: prostate cancer early detection, Version 2.2016,’ J. Natl. Compr. Canc. Netw. 14, 509–519.

Castriconi R. , Ciocca M. , Mirandola A. , Sini C. , Broggi S. , Schwarz M. , Fracchiolla F. , Martisikova M. , Arico G. , Mettivier G. , and Russo P. (2017). ‘Dose-response of EBT3 radiochromic films to proton and carbon ion clinical beams,’ Phys. Med. Biol. 62, 377–393.

Castro J.R. (1993). ‘Heavy ion therapy: The BEVALAC epoch,’ pp. 208 to 216 in Hadrontherapy in oncology: Proc. First International Symp. Hadrontherapy, Amaldi, U. and Larsson, B., Eds. (Elsevier Science, Como, Italy).

Castro J.R. (1995). ‘Future research strategy for heavy ion radiotherapy,’ pp. 643–648 in Progress in Radio-Oncology, Kogelnik H.D. , Ed. (Raven Press, New York).

Castro J.R. (1997). ‘Clinical programs: a review of past and existing hadron protocols,’ pages 79–94 in Advances in Hadron Therapy, Amaldi, U, Larrson, B, Lemoigne, Y (Eds.) (Elsevier Science, Amsterdam).

Castro J.R. , Chen G.T. , Pitluck S. , Cartigny A. , Phillips T.L. , Saunders W.M. , Collier M.J. , Woodruff K.H. , Friedman M. , and Austin-Seymour M. (1983). ‘Helium charged-particle radiotherapy of locally advanced carcinoma of the esophagus, stomach, and biliary tract,’ Am. J. Clin. Oncol. 6, 629–737.

Castro J.R. , Linstadt D.E. , Bahary J.P. , Petti P.L. , Daftari I. , Collier J.M. , Gutin P.H. , Gauger G. , and Phillips T.L. (1994). ‘Experience in charged particle irradiation of tumors of the skull base: 1977–1992,’ Int. J. Radiat. Oncol. Biol. Phys. 29, 647–655.

Chandra A. , Dong L. , Huang E. , Kuban D.A. , O'Neill L. , Rosen I. , and Pollack A. (2003). ‘Experience of ultrasound-based daily prostate localization,’ Int. J. Radiat. Oncol. Biol. Phys. 56, 436–447.

Chauvel P. , and Wambersie A. (1998). Proceedings of the EULIMA Workshop on the Potential Value of Light Ion Beam Therapy, EUR 12165 EN (Centre Antoine-Lacassagne, Nice, France).

Chen G.T. , Singh R.P. , Castro J.R. , Lyman J.T. , and Quivey J.M. (1979). ‘Treatment planning for heavy ion radiotherapy,’ Int. J. Radiat. Oncol. Biol. Phys. 5, 1809–1819.

Chen G.T. , Kung J.H. , and Rietzel E. (2007). ‘Four-dimensional imaging and treatment planning of moving targets,’ Front. Radiat. Ther. Oncol. 40, 59–71.

Chen G.T. , Sharp G.C. , and Mori S. (2009). ‘A review of image-guided radiotherapy,’ Radiol. Phys. Technol. 2, 1–12.

Chen W. , Unkelbach J. , Trofimov A. , Madden T. , Kooy H. , Bortfeld T. , and Craft D. (2012). ‘Including robustness in multi-criteria optimization for intensity-modulated proton therapy,’ Phys. Med. Biol. 57, 591–608.

Chen W. , Gemmel A. , and Rietzel E. (2013a). ‘Feature-based plan adaptation for fast treatment planning in scanned ion beam therapy,’ Phys. Med. Biol. 58, 1013–1025.

Chen W.J. , Gemmel A. , and Rietzel E. (2013b). ‘A patient-specific planning target volume used in ‘plan of the day’ adaptation for interfractional motion mitigation,’ J. Radiat. Res. 54, 82–90.

Chu W. , Ludewigt B. , and Renner T. (1993). ‘Instrumentation for treatment of cancer using proton and light‐ion beams,’ Rev. Sci. Instrum. 64, 2055–2122.

Combs S.E. , Jäkel O. , Haberer T. , and Debus J. (2010). ‘Particle therapy at the Heidelberg Ion Therapy Center (HIT) – integrated research-driven university-hospital-based radiation oncology service in Heidelberg, Germany,’ Radiother. Oncol. 95, 41–44.

Cometto A. , Russo G. , Bourhaleb F. , Milian F. , Giordanengo S. , Marchetto F. , Cirio R. , and Attili A. (2014). ‘Direct evaluation of radiobiological parameters from clinical data in the case of ion beam therapy: an alternative approach to the relative biological effectiveness,’ Phys. Med. Biol. 59, 7393.

Constantinescu A. , Lehmann H.I. , Packer D.L. , Bert C. , Durante M. , and Graeff C. (2016). ‘Treatment planning studies in patient data with scanned carbon ion beams for catheter-free ablation of atrial fibrillation,’ J. Cardiovasc. Electrophysiol. 27, 335–344.

Cui Y. , Dy J.G. , Sharp G.C. , Alexander B. , and Jiang S.B. (2007). ‘Robust fluoroscopic respiratory gating for lung cancer radiotherapy without implanted fiducial markers,’ Phys. Med. Biol. 52, 741–755.

Dawson L.A. , Kavanagh B.D. , Paulino A.C. , Das S.K. , Miften M. , Li X.A. , Pan C. , Ten Haken R.K. , and Schultheiss T.E. (2010). ‘Radiation-associated kidney injury,’ Int. J. Radiat. Oncol. Biol. Phys. 76, S108–S115.

Deutschmann H. , Neuner M. , Steininger P. , Pinzger M. , Buck M. , and Sedlmayer F. (2013). ‘Robotic positioning and imaging,’ Strahlenther. Onkol. 189, 185.

Dias M.F. , Riboldi M. , Seco J. , Castelhano I. , Pella A. , Mirandola A. , Peralta L. , Ciocca M. , Orecchia R. , and Baroni G. (2015). ‘Scan path optimization with/without clustering for active beam delivery in charged particle therapy,’ Phys. Med. 31, 130–136.

Differding S. , Hanin F.X. , and Gregoire V. (2015). ‘PET imaging biomarkers in head and neck cancer,’ Eur. J. Nucl. Med. Mol. Imaging 42, 613–622.

DIN (2009). Deutsches Institut für Normung. Qualitätsmanagementsystem in der Medizinischen Radiologie – Teil 1: Strahlentherapie, DIN 6870-1:2009-02 (Beuth Verlag GmbH, Berlin).

DIN (2016). Deutsches Institut für Normung. Procedures of Dosimetry with Probe-Type Detectors for Proton and Ion Radiation – Part 1: Ionization Chambers, DIN 6801-1:2016-06 (Beuth Verlag GmbH, Berlin). https://www.din.de/de/mitwirken/normenausschuesse/nar/entwuerfe/wdc-beuth:din21:254527246

Dingfelder M. (2014). ‘Updated model for dielectric response function of liquid water,’ Appl. Radiat. Isot. 83 Pt B, 142–147.

Dingfelder M. , Hantke D. , Inokuti M. , and Paretzke H.G. (1998). ‘Electron inelastic-scattering cross sections in liquid water,’ Radiat. Phys. Chem. 53, 1–18.

Dong Y. , Guan H. , Huang W. , Zhang Z. , Zhao D. , Liu Y. , Zhou T. , and Li B. (2015). ‘Precise delineation of clinical target volume for crossing-segments thoracic esophageal squamous cell carcinoma based on the pattern of lymph node metastases,’ J. Thorac. Dis. 7, 2313–2320.

Dreher C. , Scholz C. , Pommer M. , Brons S. , Prokesch H. , Ecker S. , Debus J. , Jäkel O. , Combs S.E. , and Habermehl D. (2016). ‘Optimization of carbon ion treatment plans by integrating tissue specific alpha/beta-values for patients with non-resectable pancreatic cancer,’ PLoS One 11, e0164473.

Durante M. , and Loeffler J.S. (2010). ‘Charged particles in radiation oncology,’ Nat. Rev. Clin. Oncol. 7:37–43.

Ebner D.K. , Tsuji H. , Yasuda S. , Yamamoto N. , Mori S. , and Kamada T. (2017). ‘Respiration-gated fast-rescanning carbon-ion radiotherapy,’ Jpn. J. Clin. Oncol. 47, 80–83.

Eckermann M. , Hillbrand M. , Herbst M. , and Rinecker H. (2011). ‘Scanning proton beam radiotherapy under functional apnea,’ page 6.1.1 in Proton Therapy: Clinical Oppotrunities (Webinar) 50, https://www.oncolink.org/conferences/coverage/ptcog/oncolink-at-ptcog-2011/ptcog-may-14-2011/scanning-proton-beam-radiotherapy-under-functional-apnea (17 July 2018, date last accessed). (University of Pennsylvania, Philadelphia).

Edmund J.M. , and Nyholm T. (2017). ‘A review of substitute CT generation for MRI-only radiation therapy,’ Radiat. Oncol. 12, 28–42.

Eickhoff H. , Haberer T. , Kraft G. , Krause U. , Richter M. , Steiner R. , and Debus J. (1999). ‘The GSI Cancer Therapy Project,’ Strahlenther. Onkol. 175, 21–24.

Eley J.G. , Newhauser W.D. , Luchtenborg R. , Graeff C. , and Bert C. (2014). ‘4D optimization of scanned ion beam tracking therapy for moving tumors,’ Phys. Med. Biol. 59, 3431–3452.

Eley J.G. , Newhauser W.D. , Richter D. , Luchtenborg R. , Saito N. , and Bert C. (2015). ‘Robustness of target dose coverage to motion uncertainties for scanned carbon ion beam tracking therapy of moving tumors,’ Phys. Med. Biol. 60, 1717–1740.

Ellerbrock M. , Jäkel O. , Krämer M. , Nikoghosyan A. , and Schulz-Ertner D. (2006). ‘Clinical implementation of multiple field dose optimization in heavy ion treatment planning,’ Radiother. Oncol. 81, S358.

Ellerbrock M. , Jäkel O. , Krämer M. , Nikoghosyan A. , Schulz-Ertner D. , Karger C.P. , Ackermann B. , Heeg P. , and Debus J. (2008). ‘Clinical implementation of intensity modulated heavy ion therapy,’ Int. J. Radiat. Oncol. 84, S592.

Elsässer T. , and Scholz M. (2007). ‘Cluster effects within the local effect model,’ Radiat. Res. 167, 319–329.

Elsässer T. , Kramer M. , and Scholz M. (2008). ‘Accuracy of the local effect model for the prediction of biologic effects of carbon ion beams in vitro and in vivo,’ Int. J. Radiat. Oncol. Biol. Phys. 71, 866–872.

Elsässer T. , Weyrather W.K. , Friedrich T. , Durante M. , Iancu G. , Kramer M. , Kragl G. , Brons S. , Winter M. , Weber K.J. , and Scholz M. (2010). ‘Quantification of the relative biological effectiveness for ion beam radiotherapy: Direct experimental comparison of proton and carbon ion beams and a novel approach for treatment planning,’ Int. J. Radiat. Oncol. Biol. Phys. 78, 1177–1183.

Emfietzoglou D. , Garcia-Molina R. , Kyriakou I. , Abril I. , and Nikjoo H. (2009). ‘A dielectric response study of the electronic stopping power of liquid water for energetic protons and a new I-value for water,’ Phys. Med. Biol. 54, 3451–3472.

Endo M. , Koyamaito H. , Minohara S. , Miyahara N. , Tomura H. , Kanai T. , Kawachi K. , Tsujii H. , and Morita K. (1996). ‘HIPLAN – a heavy ion treatment planning system at HIMAC,’ J. Jpn. Soc. Ther. Radiol. Oncol. 8, 231–238.

Endo S. , Tanaka K. , Ishikawa M. , Hoshi M. , Onizuka Y. , Takada M. , Yamaguchi H. , Hayabuchi N. , Maeda N. , and Shizuma K. (2005). ‘Microdosimetric evaluation of the 400 MeV/ nucleon carbon beam at HIMAC,’ Med. Phys. 32, 3843–3848.

Enghardt W. , Fromm W.D. , Manfrass P. , and Schardt D. (1992). ‘Limited-angle 3D reconstruction of PET images for dose localization in light ion tumour therapy,’ Phys. Med. Biol. 37, 791–798.

Enghardt W. , Crespo P. , Fiedler F. , Hinz R. , Parodi K. , Pawelke J. , and Ponisch F. (2004a). ‘Charged hadron tumour therapy monitoring by means of PET,’ Nucl. Inst. Methods Phys. Res. A 525, 284–288.

Enghardt W. , Parodi K. , Crespo P. , Fiedler F. , Pawelke J. , and Ponisch F. (2004b). ‘Dose quantification from in-beam positron emission tomography,’ Radiother. Oncol. 73, S96–S98.

Evans P.M. (2008). ‘Anatomical imaging for radiotherapy,’ Phys. Med. Biol. 53, R151–R191.

Fattori G. , Riboldi M. , Pella A. , Peroni M. , Cerveri P. , Desplanques M. , Fontana G. , Tagaste B. , Valvo F. , Orecchia R. , and Baroni G. (2015). ‘Image guided particle therapy in CNAO room 2: implementation and clinical validation,’ Phys. Med. 31, 9–15.

Feldmeier E. , Haberer T. , Peters A. , Schoemers C. , and Steiner R. (2010). ‘Magnetic field correction in normal conducting synchrotrons,’ pp. 675–677 in Proc. IPAC'10 (CERN, Geneva).

Fiedler F. , Priegnitz M. , Julich R. , Pawelke J. , Crespo P. , Parodi K. , Ponisch F. , and Enghardt W. (2008). ‘In-beam PET measurements of biological half-lives of ¹²C irradiation induced beta⁺-activity,’ Acta Oncol. 47, 1077–1086.

Flanz J. , Jäkel O. , Ford E. , Hahn S. , Mazal A. , and Daartz J. (2016a). PTCOG Safety Group Report on Aspects of Safety in Particle Therapy: Version 2 (Particle Therapy Co-Operative Group, Boston). https://www.ptcog.ch/archive/Software_and_Docs/PTCOG_Safety_Report_2.pdf (21 December 2018, date last accessed).

Flanz J. , Litzenberg D. , Chen H. , and Schreuder N. (2016b). PTCOG White Paper on Particle Therapy Efficiency: Aspects of Quality Assurance, Version 1 (Particle Therapy Co-Operative Group, Boston). https://www.ptcog.ch/archive/Software_and_Docs/White_Paper_QA_Efficiency.pdf (21 December 2018, date last accessed).

Fossati P. , Molinelli S. , Matsufuji N. , Ciocca M. , Mirandola A. , Mairani A. , Mizoe J. , Hasegawa A. , Imai R. , Kamada T. , Orecchia R. , and Tsujii H. (2012). ‘Dose prescription in carbon ion radiotherapy: a planning study to compare NIRS and LEM approaches with a clinically-oriented strategy,’ Phys. Med. Biol. 57, 7543–7554.

Fraass B. , Doppke K. , Hunt M. , Kutcher G. , Starkschall G. , Stern R. , and Van Dyke J. (1998). ‘AAPM Radiation Therapy Committee Task Group 53: Quality assurance for clinical radiotherapy treatment planning,’ Med. Phys. 25, 1773–1829.

Fredriksson A. , Forsgren A. , and Hardemark B. (2015). ‘Maximizing the probability of satisfying the clinical goals in radiation therapy treatment planning under setup uncertainty,’ Med. Phys. 42, 3992–3999.

Fritz A. , Percy C. , Jack A. , Shanmugaratnam K. , Sobin L. , Parkin D.M. , and Whelan S. (2013). International Classification of Diseases for Oncology (World Health Organization, Geneva).

Fukahori M. , Matsufuji N. , Himukai T. , Kanematsu N. , Mizuno H. , Fukumura A. , Tsuji H. , and Kamada T. (2016). ‘Estimation of late rectal normal tissue complication probability parameters in carbon ion therapy for prostate cancer,’ Radiother. Oncol. 118, 136–140.

Fukuda S. , Furukawa T. , and Iwata Y. (2014). ‘Beam-delivery systems,’ pp. 53–64 in Carbon-Ion Radiotherapy: Principles, Practices, and Treatment Planning, Tsujii, H., Kamada, T., Shirai, T., Noda, K., Tsuji, H., and Karasawa, K., Eds. (Springer, Tokyo, Japan).

Fukumura A. , Hiraoka T. , Omata K. , Takeshita M. , Kawachi K. , Kanai T. , Matsufuji N. , Tomura H. , Futami Y. , Kaizuka Y. , and Hartmann G.H. (1998). ‘Carbon beam dosimetry intercomparison at HIMAC,’ Phys. Med. Biol. 43, 3459–3463.

Furukawa T. , Inaniwa T. , Sato S. , Tomitani T. , Minohara S. , Noda K. , and Kanai T. (2007). ‘Design study of a raster scanning system for moving target irradiation in heavy-ion radiotherapy,’ Med. Phys. 34, 1085–1097.

Furukawa T. , Saotome N. , Inaniwa T. , Sato S. , Noda K. , and Kanai T. (2008). ‘Delivery verification using 3D dose reconstruction based on fluorescence measurement in a carbon beam scanning irradiation system,’ Med. Phys. 35, 2235–2242.

Furukawa T. , Inaniwa T. , Sato S. , Shirai T. , Mori S. , Takeshita E. , Mizushima K. , Himukai T. , and Noda K. (2010). ‘Moving target irradiation with fast rescanning and gating in particle therapy,’ Med. Phys. 37, 4874–4879.

Furusawa Y. , Fukutsu K. , Aoki M. , Itsukaichi H. , Eguchi-Kasai K. , Ohara H. , Yatagai F. , Kanai T. , and Ando K. (2000). ‘Inactivation of aerobic and hypoxic cells from three different cell lines by accelerated ³He-, ¹²C-and ²⁰Ne-ion beams,’ Radiat. Res. 154, 485–496.

Futami Y. , Kanai T. , Fujita M. , Tomura H. , Higashi A. , Matsufuji N. , Miyahara N. , Endo M. , and Kawachi K. (1999). ‘Broad-beam three-dimensional irradiation system for heavy-ion radiotherapy at HIMAC,’ Nucl. Inst. Methods Phys. Res. A 430, 143–153.

Galer S. , Shipley D. , Palmans H. , Kirkby K. , and Nisbet A. (2017). ‘Monte Carlo simulation of a TEPC for microdosimetry of carbon ions,’ Radiat. Phys. Chem. 140, 412–418.

Galonska M. , Scheloske S. , Cee R. , Höppner K. , Winkelmann T. , Peters A. , and Haberer T. (2011). ‘Commissioning of the ion beam gantry at HIT,’ pp. 2874 to 2876 in Proc. IPAC2011: 2nd International Particle Accelerator Conference, https://accelconf.web.cern.ch/accelconf/IPAC2011/papers/thoab03.pdf (20 December 2018, date last accessed) (European Organization for Nuclear Research, Geneva).

Geets X. , Daisne J.F. , Tomsej M. , Duprez T. , Lonneux M. , and Gregoire V. (2006). ‘Impact of the type of imaging modality on target volumes delineation and dose distribution in pharyngo-laryngeal squamous cell carcinoma: comparison between pre- and per-treatment studies,’ Radiother. Oncol. 78, 291–297.

Geets X. , Tomsej M. , Lee J.A. , Duprez T. , Coche E. , Cosnard G. , Lonneux M. , and Gregoire V. (2007). ‘Adaptive biological image-guided IMRT with anatomic and functional imaging in pharyngo-laryngeal tumors: Impact on target volume delineation and dose distribution using helical tomotherapy,’ Radiother. Oncol. 85, 105–115.

Geithner O. , Andreo P. , Sobolevsky N. , Hartmann G. , and Jäkel O. (2006). ‘Calculation of stopping power ratios for carbon ion dosimetry,’ Phys. Med. Biol. 51, 2279–2292.

Gemmel A. , Hasch B. , Ellerbrock M. , Weyrather W.K. , and Kramer M. (2008). ‘Biological dose optimization with multiple ion fields,’ Phys. Med. Biol. 53, 6991–7012.

Ghadjar P. , Schreiber-Facklam H. , Grater R. , Evers C. , Simcock M. , Geretschlager A. , Blumstein N.M. , Zbaren P. , Zimmer Y. , Wilkens L. , and Aebersold D.M. (2010). ‘Quantitative analysis of extracapsular extension of metastatic lymph nodes and its significance in radiotherapy planning in head and neck squamous cell carcinoma,’ Int. J. Radiat. Oncol. Biol. Phys. 76, 1127–1132.

Glowa C. , Karger C.P. , Brons S. , Zhao D. , Mason R.P. , Huber P.E. , Debus J. , and Peschke P. (2016). ‘Carbon ion radiotherapy decreases the impact of tumor heterogeneity on radiation response in experimental prostate tumors,’ Cancer Lett. 378, 97–103.

Gol'din L. , Dzhelepov V. , Lomanov M. , Savchenko O. , and Khoroshkov V.S. (1973). ‘Application of high-energy heavy charged particles in medicine,’ Phys.-Uspekhi 16, 402–413.

Goldhaber A.S. , and Heckman H.H. (1978). ‘High-energy interactions of nuclei,’ Annu. Rev. Nucl. Part. Sci. 28, 161–205.

Goma C. , Andreo P. , and Sempau J. (2013). ‘Spencer-Attix water/medium stopping-power ratios for the dosimetry of proton pencil beams,’ Phys. Med. Biol. 58, 2509–2522.

Goma C. , Lorentini S. , Meer D. , and Safai S. (2014). ‘Proton beam monitor chamber calibration,’ Phys. Med. Biol. 59, 4961–4971.

Gottschalk B. (2010). ‘On the scattering power of radiotherapy protons,’ Med. Phys. 37, 352–367.

Gough R.A. (1987). ‘The Light Ion Biomedical Research Accelerator (LIBRA),’ pp. 117 to 125 in Proc. 5thPTCOG Meeting and International Workshop on Biomedical Accelerators, LBL-22962 (National Technical Information Service, Springfield, Virginia).

Graeff C. (2017). ‘Robustness of 4D-optimized scanned carbon ion beam therapy against interfractional changes in lung cancer,’ Radiother. Oncol. 122, 387–392.

Graeff C. , Durante M. , and Bert C. (2012). ‘Motion mitigation in intensity modulated particle therapy by internal target volumes covering range changes,’ Med. Phys. 39, 6004–6013.

Graeff C. , Constantinescu A. , Luchtenborg R. , Durante M. , and Bert C. (2014). ‘Multigating, a 4D optimized beam tracking in scanned ion beam therapy,’ Technol. Cancer Res. Treat. 13, 497–504.

Graffman S. , Brahme A. , and Larsson B. (1985). ‘Proton radiotherapy with the Uppsala cyclotron. Experience and plans,’ Strahlentherapie 161, 764–770.

Greca V. (2018). Therapeutic Particles [online], CERN Courier, https://cerncourier.com/therapeutic-particles/ (December 16 2018, date last accessed) (IOP Publishing, Bristol, United Kingdom).

Grégoire V. , Coche E. , Cosnard G. , Hamoir M. , and Reychler H. (2000). ‘Selection and delineation of lymph node target volumes in head and neck conformal radiotherapy. Proposal for standardizing terminology and procedure based on the surgical experience,’ Radiother. Oncol. 56, 135–150.

Grégoire V. , Pötter R. , and Wambersie A. (2004). ‘General principles for prescribing, recording and reporting a therapeutic irradiation,’ Radiother. Oncol. 73, S57–S61.

Grégoire V. , Jeraj R. , Lee J.A. , and O'Sullivan B. (2012). ‘Radiotherapy for head and neck tumours in 2012 and beyond: Conformal, tailored, and adaptive?,’ Lancet Oncol. 13, e292–e300.

Grégoire V. , Scalliet P. , and Ang K. (2013). Clinical Target Volumes in Conformal and Intensity Modulated Radiation Therapy: A Clinical Guide to Cancer Treatment (Springer Science & Business Media, Berlin).

Grégoire V. , Ang K. , Budach W. , Grau C. , Hamoir M. , Langendijk J.A. , Lee A. , Le Q.T. , Maingon P. , Nutting C. , O'Sullivan B. , Porceddu S.V. , and Lengele B. (2014). ‘Delineation of the neck node levels for head and neck tumors: A 2013 update. DAHANCA, EORTC, HKNPCSG, NCIC CTG, NCRI, RTOG, TROG consensus guidelines,’ Radiother. Oncol. 110, 172–181.

Grozinger S.O. , Rietzel E. , Li Q. , Bert C. , Haberer T. , and Kraft G. (2006). ‘Simulations to design an online motion compensation system for scanned particle beams,’ Phys. Med. Biol. 51, 3517–3531.

Grozinger S.O. , Bert C. , Haberer T. , Kraft G. , and Rietzel E. (2008). ‘Motion compensation with a scanned ion beam: a technical feasibility study,’ Radiat. Oncol. 3, 34.

Grün R. , Friedrich T. , Kramer M. , Zink K. , Durante M. , Engenhart-Cabillic R. , and Scholz M. (2015). ‘Assessment of potential advantages of relevant ions for particle therapy: a model based study,’ Med. Phys. 42, 1037–1047.

Grunder H. , Hartsough W. , and Lofgren E. (1971). ‘Acceleration of heavy ions at the Bevatron,’ Science 174, 1128–1129.

Guan F. , Peeler C. , Bronk L. , Geng C. , Taleei R. , Randeniya S. , Ge S. , Mirkovic D. , Grosshans D. , and Mohan R. (2015). ‘Analysis of the track‐and dose‐averaged LET and LET spectra in proton therapy using the geant4 Monte Carlo code,’ Med. Phys. 42, 6234–6247.

Gudowska I. , Sobolevsky N. , Andreo P. , Belkic D. , and Brahme A. (2004). ‘Ion beam transport in tissue-like media using the Monte Carlo code SHIELD-HIT,’ Phys. Med. Biol. 49, 1933–1958.

Gueulette J. , Octave-Prignot M. , De Costera B.M. , Wambersie A. , and Gregoire V. (2004). ‘Intestinal crypt regeneration in mice: a biological system for quality assurance in non-conventional radiation therapy,’ Radiother. Oncol. 73, S148–S154.

Gueulette J. , Blattmann H. , Pedroni E. , Coray A. , De Coster B.M. , Mahy P. , Wambersie A. , and Goitein G. (2005). ‘Relative biologic effectiveness determination in mouse intestine for scanning proton beam at Paul Scherrer Institute, Switzerland. influence of motion,’ Int. J. Radiat. Oncol. Biol. Phys. 62, 838–845.

Gunzert-Marx K. , Schardt D. , and Simon R.S. (2004). ‘Fast neutrons produced by nuclear fragmentation in treatment irradiations with ¹²C beam,’ Radiat. Prot. Dosimetry 110, 595–600.

Gunzert-Marx K. , Iwase H. , Schardt D. , and Simon R. (2008). ‘Secondary beam fragments produced by 200 MeV u^{−1 12}C ions in water and their dose contributions in carbon ion radiotherapy,’ New J. Phys. 10, 075003.

Gwosch K. , Hartmann B. , Jakubek J. , Granja C. , Soukup P. , Jäkel O. , and Martisikova M. (2013). ‘Non-invasive monitoring of therapeutic carbon ion beams in a homogeneous phantom by tracking of secondary ions,’ Phys. Med. Biol. 58, 3755–3773.

Haberer T. , Becher W. , Schardt D. , and Kraft G. (1993). ‘Magnetic scanning system for heavy-ion therapy,’ Nucl. Instrum. Methods Phys. Res. A 330, 296–305.

Haberer T. , Debus J. , Eickhoff H. , Jäkel O. , Schulz-Ertner D. , and Weber U. (2004). ‘The Heidelberg Ion Therapy Center,’ Radiother. Oncol. 73, S186–S190.

Habermehl D. , Debus J. , Ganten T. , Ganten M.-K. , Bauer J. , Brecht I.C. , Brons S. , Haberer T. , Haertig M. , and Jäkel O. (2013a). ‘Hypofractionated carbon ion therapy delivered with scanned ion beams for patients with hepatocellular carcinoma–feasibility and clinical response,’ Radiat. Oncol. 8, 59.

Habermehl D. , Henkner K. , Ecker S. , Jäkel O. , Debus J. , and Combs S.E. (2013b). ‘Evaluation of different fiducial markers for image-guided radiotherapy and particle therapy,’ J. Radiat. Res. 54, i61–i68.

Habl G. , Uhl M. , Katayama S. , Kessel K.A. , Hatiboglu G. , Hadaschik B. , Edler L. , Tichy D. , Ellerbrock M. , Haberer T. , Wolf M.B. , Schlemmer H.P. , Debus J. , and Herfarth K. (2016). ‘Acute toxicity and quality of life in patients with prostate cancer treated with protons or carbon ions in a prospective randomized phase II study – the IPI Trial,’ Int. J. Radiat. Oncol. Biol. Phys. 95, 435–443.

Haettner E. , Iwase H. , Krämer M. , Kraft G. , and Schardt D. (2013). ‘Experimental study of nuclear fragmentation of 200 and 400 MeV/u ¹²C ions in water for applications in particle therapy,’ Phys. Med. Biol. 58, 8265.

Hanley J. , Debois M.M. , Mah D. , Mageras G.S. , Raben A. , Rosenzweig K. , Mychalczak B. , Schwartz L.H. , Gloeggler P.J. , Lutz W. , Ling C.C. , Leibel S.A. , Fuks Z. , and Kutcher G.J. (1999). ‘Deep inspiration breath-hold technique for lung tumors: the potential value of target immobilization and reduced lung density in dose escalation,’ Int. J. Radiat. Oncol. Biol. Phys. 45, 603–611.

Hara Y. , Furukawa T. , Inaniwa T. , Mizushima K. , Shirai T. , and Noda K. (2014). ‘A novel method for experimental characterization of large-angle scattered particles in scanned carbon-ion therapy,’ Med. Phys. 41, 021706.

Hara Y. , Furukawa T. , Mizushima K. , Inaniwa T. , Saotome N. , Tansho R. , Saraya Y. , Shirai T. , and Noda K. (2017). ‘Commissioning of full energy scanning irradiation with carbon-ion beams ranging from 55.6 to 430 MeV/u at the NIRS-HIMAC,’ Nucl. Instrum. Methods Phys. Res. B 406, 343–346.

Harris V.A. , Staffurth J. , Naismith O. , Esmail A. , Gulliford S. , Khoo V. , Lewis R. , Littler J. , McNair H. , Sadoyze A. , Scrase C. , Sohaib A. , Syndikus I. , Zarkar A. , Hall E. , Dearnaley D. , and Trialists P. (2015). ‘Consensus guidelines and contouring atlas for pelvic node delineation in prostate and pelvic node intensity modulated radiation therapy,’ Int. J. Radiat. Oncol. Biol. Phys. 92, 874–883.

Hartmann G.H. , Jäkel O. , Heeg P. , Karger C.P. , and Kriessbach A. (1999). ‘Determination of water absorbed dose in a carbon ion beam using thimble ionization chambers,’ Phys. Med. Biol. 44, 1193–1206.

Hartmann B. , Telsemeyer J. , Huber L. , Ackermann B. , Jäkel O. , and Martisikova M. (2012). ‘Investigations of a flat-panel detector for quality assurance measurements in ion beam therapy,’ Phys. Med. Biol. 57, 51–68.

Hasegawa A. , Mizoe J.E. , Mizota A. , and Tsujii H. (2006). ‘Outcomes of visual acuity in carbon ion radiotherapy: analysis of dose-volume histograms and prognostic factors,’ Int. J. Radiat. Oncol. Biol. Phys. 64, 396–401.

Hawkins R.B. (1994). ‘A statistical theory of cell killing by radiation of varying linear energy transfer,’ Radiat. Res. 140, 366–374.

Hawkins R.B. (1996). ‘A microdosimetric-kinetic model of cell death from exposure to ionizing radiation of any LET, with experimental and clinical applications,’ Int. J. Radiat. Biol. 69, 739–755.

Heiland M. , Schulze D. , Blake F. , and Schmelzle R. (2005). ‘Intraoperative imaging of zygomaticomaxillary complex fractures using a 3D C-arm system,’ Int. J. Oral Maxillofac. Surg. 34, 369–375.

Heilbron J.L. , and Seidel R.W. (1989). Lawrence and his Labroratory: A History of the Lawrence Berkeley Laboratory (University of California Press, Berkeley).

Henderson F.C. , McCool K. , Seigle J. , Jean W. , Harter W. , and Gagnon G.J. (2009). ‘Treatment of chordomas with cyberknife: Georgetown University experience and treatment recommendations,’ Neurosurgery 64, A44–A53.

Henkner K. , Bassler N. , Sobolevsky N. , and Jäkel O. (2009). ‘Monte Carlo simulations on the water-to-air stopping power ratio for carbon ion dosimetry,’ Med. Phys. 36, 1230–1235.

Henkner K. , Winter M. , Echner G. , Ackermann B. , Brons S. , Horn J. , Jäkel O. , and Karger C.P. (2015). ‘A motorized solid-state phantom for patient-specific dose verification in ion beam radiotherapy,’ Phys. Med. Biol. 60, 7151–7163.

Hermanek P. , Wittekind C. , and Altendorfhofmann A. (1994). ‘Uicc classification of pancreatic ductal adenocarcinoma,’ Int. J. Pancreatol. 16230–232.

Hild S. , Graeff C. , Rucinski A. , Zink K. , Habl G. , Durante M. , Herfarth K. , and Bert C. (2016). ‘Scanned ion beam therapy for prostate carcinoma: Comparison of single plan treatment and daily plan-adapted treatment,’ Strahlenther. Onkol. 192, 118–126.

Hiramoto K. , and Nishi M. (1992). ‘Resonant beam extraction scheme with constant separatrix,’ Nucl. Instrum. Methods Phys. Res. A 322, 154–160.

Hockel M. , Horn L.C. , Tetsch E. , and Einenkel J. (2012). ‘Pattern analysis of regional spread and therapeutic lymph node dissection in cervical cancer based on ontogenetic anatomy,’ Gynecol. Oncol. 125, 168–174.

Hof H. , Herfarth K.K. , Munter M. , Hoess A. , Motsch J. , Wannenmacher M. , and Debus J.J. (2003). ‘Stereotactic single-dose radiotherapy of stage I non-small-cell lung cancer (NSCLC),’ Int. J. Radiat. Oncol. Biol. Phys. 56, 335–341.

Hojo S. , Honma T. , Sakamoto Y. , and Yamada S. (2005). ‘Production of ¹¹C-beam for particle therapy,’ Nucl. Instrum. Methods Phys. Res. B 240, 75–78.

Hong L. , Goitein M. , Bucciolini M. , Comiskey R. , Gottschalk B. , Rosenthal S. , Serago C. , and Urie M. (1996). ‘A pencil beam algorithm for proton dose calculations,’ Phys. Med. Biol. 41, 1305–1330.

Hornsey S. (1991). ‘Experimental central nervous system injury from fast neutrons,’ pp. 137–148 in Radiation Injury to the Nervous System, Gutin P.H, Leibel S.A, and Sheline G.E., Eds. (Raven Press, New York).

Houweling A.C. , Fukata K. , Kubota Y. , Shimada H. , Rasch C.R. , Ohno T. , Bel A. , and van der Horst A. (2016). ‘The impact of interfractional anatomical changes on the accumulated dose in carbon ion therapy of pancreatic cancer patients,’ Radiother. Oncol. 119, 319–325.

Hua C. , Lovelock D.M. , Mageras G.S. , Katz M.S. , Mechalakos J. , Lief E.P. , Hollister T. , Lutz W.R. , Zelefsky M.J. , and Ling C.C. (2003). ‘Development of a semi-automatic alignment tool for accelerated localization of the prostate,’ Int. J. Radiat. Oncol. Biol. Phys. 55, 811–824.

Hugo G.D. , and Rosu M. (2012). ‘Advances in 4D radiation therapy for managing respiration: Part I – 4D imaging,’ Z. Med. Phys. 22, 258–271.

Hünemohr N. , Paganetti H. , Greilich S. , Jäkel O. , and Seco J. (2014). ‘Tissue decomposition from dual energy CT data for MC based dose calculation in particle therapy,’ Med. Phys. 41, 061714.

Huq M.S. , Fraass B.A. , Dunscombe P.B. , Gibbons J.P. , Ibbott G.S. , Mundt A.J. , Mutic S. , Palta J.R. , Rath F. , and Thomadsen B.R. (2016). ‘The report of Task Group 100 of the AAPM: application of risk analysis methods to radiation therapy quality management,’ Med. Phys. 43, 4209–4262.

IAEA (2000). International Atomic Energy Agency. Absorbed Dose Determination in External Beam Radiotherapy: An International Code of Practice for Dosimetry Based on Standards of Absorbed Dose to Water, IAEA TRS-398 (International Atomic Energy Agency, Vienna).

IAEA (2004). International Atomic Energy Agency. Commissioning and Quality Assurance of Computerized Planning Systems for Radiation Treatment of Cancer, IAEA TRS-340 (International Atomic Energy Agency, Vienna).

IAEA (2007a). International Atomic Energy Agency. Dose Reporting in Ion Beam Therapy, IAEA TECDOC-1560 (International Atomic Energy Agency, Vienna).

IAEA (2007b). International Atomic Energy Agency. Specification and Acceptance Testing of Radiotherapy Treatment Planning Systems, IAEA TECDOC-1540 (International Atomic Energy Agency, Vienna).

IAEA (2008). International Atomic Energy Agency. Relative Biological Effectiveness in Ion Beam Therapy, Technical Reports Series No. 461 (International Atomic Energy Agency, Vienna).

ICRP (2014). International Commission on Radiological Protection. Radiological Protection in Ion Beam Radiotherapy, ICRP Publication 127, Ann. ICRP 43 (Sage Publications, Thousand Oaks, California).

ICRU (1970). International Commission on Radiation Units and Measurements. Linear Energy Transfer. ICRU Report 16 (International Commission on Radiation Units and Measurements, Bethesda, Maryland).

ICRU (1979). International Commission on Radiation Units and Measurements. Quantitative Concepts and Dosimetry in Radiobiology. ICRU Report 30 (International Commission on Radiation Units and Measurements, Bethesda, Maryland).

ICRU (1983). International Commission on Radiation Units and Measurements. Microdosimetry. ICRU Report 36 (International Commission on Radiation Units and Measurements, Bethesda, Maryland).

ICRU (1984). International Commission on Radiation Units and Measurements. Stopping Powers for Electrons and Positrons. ICRU Report 37 (International Commission on Radiation Units and Measurements, Bethesda, Maryland).

ICRU (1986). International Commission on Radiation Units and Measurements. The Quality Factor in Radiation Protection. ICRU Report 40 (International Commission on Radiation Units and Measurements, Bethesda, Maryland).

ICRU (1993a). International Commission on Radiation Units and Measurements. Stopping Powers and Ranges for Protons and Alpha Particles. ICRU Report 49 (International Commission on Radiation Units and Measurements, Bethesda, Maryland).

ICRU (1993b). International Commission on Radiation Units and Measurements. Prescribing, Recording and Reporting Photon Beam Therapy. ICRU Report50 (International Commission on Radiation Units and Measurements, Bethesda, MD Maryland).

ICRU (1998). International Commission on Radiation Units and Measurements. Clinical Proton Dosimetry Part I: Beam Production, Beam Delivery and Measurement of Absorbed Dose. ICRU Report 59 (International Commission on Radiation Units and Measurements, Bethesda, Maryland).

ICRU (1999). International Commission on Radiation Units and Measurements. Prescribing, Recording and Reporting Photon Beam Therapy (Supplement to ICRU Report 50). ICRU Report 62 (International Commission on Radiation Units and Measurements, Bethesda, Maryland).

ICRU (2004). International Commission on Radiation Units and Measurements. ‘Prescribing, recording, and reporting electron beam therapy,’ ICRU Report 71, J. ICRU 4(1).

ICRU (2005). International Commission on Radiation Units and Measurements. ‘Stopping of ions heavier than helium,’ ICRU Report 73, J. ICRU 5(1).

ICRU (2007). International Commission on Radiation Units and Measurements. ‘Prescribing, recording, and reporting proton-beam therapy,’ ICRU Report 78, J. ICRU 7(2).

ICRU (2009). International Commission on Radiation Units and Measurements. ‘Errata and addenda for ICRU Report 73, stopping of ions heavier than helium,’ ICRU Report 73, J. ICRU 5(1).

ICRU (2010). International Commission on Radiation Units and Measurements. ‘Prescribing, recording and reporting photon-beam intensity-modulated radiation therapy,’ ICRU Report 83, J. ICRU 10(1).

ICRU (2011). International Commission on Radiation Units and Measurements. ‘Fundamental quantities and units for ionizing radiation,’ ICRU Report 85, J. ICRU 11(1).

ICRU (2014). International Commission on Radiation Units and Measurements. ‘Key data for ionizing-radiation dosimetry: Measurement standards and applications,’ ICRU Report 90, J. ICRU 14(1).

IEC (2007). International Electrotechnical Commission. Medical Electrical Equipment – Medical Electron Accelerators – Functional Performance Characteristics, IEC 60976:2007 (International Electrotechnical Commission, Geneva).

IEC (2014). International Electrotechnical Commission. Medical Electrical Equipment – Part 2-64: Particular Requirements for the Basic Safety and Essential Performance of Light Ion Beam Medical Electrical Equipment, IEC 60601-2-64:2014 (International Electrotechnical Commission, Geneva).

Inaniwa T. , Kohno T. , Tomitani T. , Urakabe E. , Sato S. , Kanazawa M. , and Kanai T. (2006). ‘Experimental determination of particle range and dose distribution in thick targets through fragmentation reactions of stable heavy ions,’ Phys. Med. Biol. 51, 4129–4146.

Inaniwa T. , Furukawa T. , Matsufuji N. , Kohno T. , Sato S. , Noda K. , and Kanai T. (2007a). ‘Clinical ion beams: semi-analytical calculation of their quality,’ Phys. Med. Biol. 52, 7261.

Inaniwa T. , Furukawa T. , Tomitani T. , Sato S. , Noda K. , and Kanai T. (2007b). ‘Optimization for fast‐scanning irradiation in particle therapy,’ Med. Phys. 34, 3302–3311.

Inaniwa T. , Kohno T. , Tomitani T. , and Sato S. (2008). ‘Monitoring the irradiation field of ¹²C and ¹⁶O SOBP beams using positron emitters produced through projectile fragmentation reactions,’ Phys. Med. Biol. 53, 529–542.

Inaniwa T. , Furukawa T. , Kase Y. , Matsufuji N. , Toshito T. , Matsumoto Y. , Furusawa Y. , and Noda K. (2010). ‘Treatment planning for a scanned carbon beam with a modified microdosimetric kinetic model,’ Phys. Med. Biol. 55, 6721–6737.

Inaniwa T. , Kanematsu N. , Furukawa T. , and Hasegawa A. (2011). ‘A robust algorithm of intensity modulated proton therapy for critical tissue sparing and target coverage,’ Phys. Med. Biol. 56, 4749–4770.

Inaniwa T. , Furukawa T. , Kanematsu N. , Mori S. , Mizushima K. , Sato S. , Toshito T. , Shirai T. , and Noda K. (2012). ‘Evaluation of hybrid depth scanning for carbon-ion radiotherapy,’ Med. Phys. 39, 2820–2825.

Inaniwa T. , Kanematsu N. , Hara Y. , Furukawa T. , Fukahori M. , Nakao M. , and Shirai T. (2014a). ‘Implementation of a triple Gaussian beam model with subdivision and redefinition against density heterogeneities in treatment planning for scanned carbon-ion radiotherapy,’ Phys. Med. Biol. 59, 5361–5386.

Inaniwa T. , Kanematsu N. , Hara Y. , and Furukawa T. (2014b). ‘Nuclear-interaction correction of integrated depth dose in carbon-ion radiotherapy treatment planning,’ Phys. Med. Biol. 60, 421.

Inaniwa T. , Kanematsu N. , Matsufuji N. , Kanai T. , Shirai T. , Noda K. , Tsuji H. , Kamada T. , and Tsujii H. (2015a). ‘Reformulation of a clinical-dose system for carbon-ion radiotherapy treatment planning at the National Institute of Radiological Sciences, Japan,’ Phys. Med. Biol. 60, 3271–3286.

Inaniwa T. , Kanematsu N. , Tsuji H. , and Kamada T. (2015b). ‘Influence of nuclear interactions in body tissues on tumor dose in carbon-ion radiotherapy,’ Med. Phys. 42, 7132–7137.

Inaniwa T. , and Kanematsu N. (2015c). ‘A trichrome beam model for biological dose calculation in scanned carbon-ion radiotherapy treatment planning,’ Phys. Med. Biol. 60, 437.

Iseki Y. , Kanai T. , Kanazawa M. , Kitagawa A. , Mizuno H. , Tomitani T. , Suda M. , and Urakabe E. (2004). ‘Range verification system using positron emitting beams for heavy-ion radiotherapy,’ Phys. Med. Biol. 49, 3179–3195.

Iwata Y. , Yamada S. , Murakami T. , Fujimoto T. , Fujisawa T. , Ogawa H. , Miyahara N. , Yamamoto K. , Hojo S. , Sakamoto Y. , Muramatsu M. , Takeuchi T. , Mitsumoto T. , Tsutsui H. , Watanabe T. , and Ueda T. (2006). ‘Alternating-phase-focused IH-DTL for an injector of heavy-ion medical accelerators,’ Nucl. Instrum. Methods Phys. Res. A 569, 685–696.

Iwata Y. , Kadowaki T. , Uchiyama H. , Fujimoto T. , Takada E. , Shirai T. , Furukawa T. , Mizushima K. , Takeshita E. , Katagiri K. , Sato S. , Sano Y. , and Noda K. (2010). ‘Multiple-energy operation with extended flattops at HIMAC,’ Nucl. Instrum. Methods Phys. Res. A 624, 33–38.

Jaffray D.A. , Siewerdsen J.H. , Wong J.W. , and Martinez A.A. (2002). ‘Flat-panel cone-beam computed tomography for image-guided radiation therapy,’ Int. J. Radiat. Oncol. Biol. Phys. 53, 1337–1349.

Jäkel O. (2006). ‘Ranges of ions in metals for use in particle treatment planning,’ Phys. Med. Biol. 51, N173–N177.

Jäkel O. (2014). ‘Light-ion radiation therapy planning,’ pp. 487–504 in Comprehensive Biomedical Physics, Brahme, A., Ed. (Elsevier, Amsterdam).

Jäkel O. , and Reiss P. (2007). ‘The influence of metal artefacts on the range of ion beams,’ Phys. Med. Biol. 52, 635–644.

Jäkel O. , Hartmann G.H. , Heeg P. , and Schardt D. (2000a). ‘Effective point of measurement of cylindrical ionization chambers for heavy charged particles,’ Phys. Med. Biol. 45, 599–607.

Jäkel O. , Hartmann G.H. , Karger C.P. , Heeg P. , and Rassow J. (2000b). ‘Quality assurance for a treatment planning system in scanned ion beam therapy,’ Med. Phys. 27, 1588–1600.

Jäkel O. , Jacob C. , Schardt D. , Karger C.P. , and Hartmann G.H. (2001a). ‘Relation between carbon ion ranges and x-ray CT numbers,’ Med. Phys. 28, 701–703.

Jäkel O. , Kramer M. , Karger C.P. , and Debus J. (2001b). ‘Treatment planning for heavy ion radiotherapy: clinical implementation and application,’ Phys. Med. Biol. 46, 1101–1116.

Jäkel O. , Hartmann G.H. , Karger C.P. , Heeg P. , and Vatnitsky S. (2004). ‘A calibration procedure for beam monitors in a scanned beam of heavy charged particles,’ Med. Phys. 31, 1009–1013.

Jäkel O. , Schulz-Ertner D. , and Debus J. (2007). ‘Specifying carbon ion doses for radiotherapy: the heidelberg approach,’ J. Radiat. Res. 48, A87–A95.

Jensen A.D. , Winter M. , Kuhn S.P. , Debus J. , Nairz O. , and Munter M.W. (2012). ‘Robotic-based carbon ion therapy and patient positioning in 6 degrees of freedom: setup accuracy of two standard immobilization devices used in carbon ion therapy and IMRT,’ Radiat. Oncol. 7, 51.

Johnson R.P. , Bashkirov V. , DeWitt L. , Giacometti V. , Hurley R.F. , Piersimoni P. , Plautz T.E. , Sadrozinski H.F.W. , Schubert K. , and Schulte R. (2016). ‘A fast experimental scanner for proton CT: technical performance and first experience with phantom scans,’ IEEE Trans. Nucl. Sci. 63, 52–60.

Jongen Y. , Kleeven W. , Zaremba S. , Vandeplassche D. , Beeckman W. , Aleksandrov V. , Karamysheva G. , Kazarinov N.Y. , Kian I. , Kostromin S. , Morozov N. , Samsonov E. , Shirkov G. , Shevtsov V. , and Syresin E. (2006). ‘Design studies of the compact superconducting cyclotron for hadron therapy,’ pp. 1678–1680 in Proc. EPAC 2006 (European Physical Society Accelerator Group, Mulhouse, France).

Kaderka R. , Schardt D. , Durante M. , Berger T. , Ramm U. , Licher J. , and La Tessa C. (2012). ‘Out-of-field dose measurements in a water phantom using different radiotherapy modalities,’ Phys. Med. Biol. 57, 5059–5074.

Kamada T. , Tsujii H. , Mizoe J.E. , Matsuoka Y. , Tsuji H. , Osaka Y. , Minohara S. , Miyahara N. , Endo M. , and Kanai T. (1999). ‘A horizontal CT system dedicated to heavy-ion beam treatment,’ Radiother. Oncol. 50, 235–237.

Kanai T. , Kawachi K. , Matsuzawa H. , and Inada T. (1983). ‘Broad beam three-dimensional irradiation for proton radiotherapy,’ Med. Phys. 10, 344–346.

Kanai T. , Furusawa Y. , Fukutsu K. , Itsukaichi H. , Eguchi-Kasai K. , and Ohara H. (1997). ‘Irradiation of mixed beam and design of spread-out Bragg peak for heavy-ion radiotherapy,’ Radiat. Res. 147, 78–85.

Kanai T. , Endo M. , Minohara S. , Miyahara N. , Koyama-ito H. , Tomura H. , Matsufuji N. , Futami Y. , Fukumura A. , Hiraoka T. , Furusawa Y. , Ando K. , Suzuki M. , Soga F. , and Kawachi K. (1999). ‘Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy,’ Int. J. Radiat. Oncol. Biol. Phys. 44, 201–210.

Kanai T. , Fukumura A. , Kusano Y. , Shimbo M. , and Nishio T. (2004). ‘Cross-calibration of ionization chambers in proton and carbon beams,’ Phys. Med. Biol. 49, 771–781.

Kanazawa M. , Kitagawa A. , Kouda S. , Nishio T. , Torikoshi A. , Noda K. , Murakami T. , Suda M. , Tomitani T. , Kanai T. , Futami Y. , Shinbo M. , Urakabe E. , and Iseki Y. (2002). ‘Application of an RI-beam for cancer therapy: In-vivo verification of the ion-beam range by means of positron imaging,’ Nucl. Phys. A 701, 244c–252c.

Kanematsu N. (2009). ‘Semi-empirical formulation of multiple scattering for the Gaussian beam model of heavy charged particles stopping in tissue-like matter,’ Phys. Med. Biol. 54, N67–N73.

Kanematsu N. , Endo M. , Futami Y. , Kanai T. , Asakura H. , Oka H. , and Yusa K. (2002). ‘Treatment planning for the layer-stacking irradiation system for three-dimensional conformal heavy-ion radiotherapy,’ Med. Phys. 29, 2823–2829.

Kanematsu N. , Matsufuji N. , Kohno R. , Minohara S. , and Kanai T. (2003). ‘A CT calibration method based on the polybinary tissue model for radiotherapy treatment planning,’ Phys. Med. Biol. 48, 1053–1064.

Kanematsu N. , Torikoshi M. , Mizota M. , and Kanai T. (2007). ‘Secondary range shifting with range compensator for reduction of beam data library in heavy-ion radiotherapy,’ Med. Phys. 34, 1907–1910.

Kanematsu N. , Inaniwa T. , and Nakao M. (2016). ‘Modeling of body tissues for Monte Carlo simulation of radiotherapy treatments planned with conventional x-ray CT systems,’ Phys. Med. Biol. 61, 5037–5050.

Kantemiris I. , Karaiskos P. , Papagiannis P. , and Angelopoulos A. (2011). ‘Dose and dose averaged LET comparison of ¹H, ⁴He, ⁶Li, ⁸Be, ¹⁰B, ¹²C, ¹⁴N, and ¹⁶O ion beams forming a spread‐out Bragg peak,’ Med. Phys. 38, 6585–6591.

Kardar L. , Li Y. , Li X. , Li H. , Cao W. , Chang J.Y. , Liao L. , Zhu R.X. , Sahoo N. , Gillin M. , Liao Z. , Komaki R. , Cox J.D. , Lim G. , and Zhang X. (2014). ‘Evaluation and mitigation of the interplay effects of intensity modulated proton therapy for lung cancer in a clinical setting,’ Pract. Radiat. Oncol. 4, e259–e268.

Karger C.P. , Jäkel O. , and Hartmann G.H. (1999). ‘A system for three-dimensional dosimetric verification of treatment plans in intensity-modulated radiotherapy with heavy ions,’ Med. Phys. 26, 2125–2132.

Karger C.P. , Hartmann G.H. , Jäkel O. , and Heeg P. (2000). ‘Quality management of medical physics issues at the German heavy ion therapy project,’ Med. Phys. 27, 725–736.

Karger C.P. , Jäkel O. , Debus J. , Kuhn S. , and Hartmann G.H. (2001a). ‘Three-dimensional accuracy and interfractional reproducibility of patient fixation and positioning using a stereotactic head mask system,’ Int. J. Radiat. Oncol. Biol. Phys. 49, 1493–1504.

Karger C.P. , Hartmann G.H. , Heeg P. , and Jäkel O. (2001b). ‘A method for determining the alignment accuracy of the treatment table axis at an isocentric irradiation facility,’ Phys. Med. Biol. 46, N19–N26.

Karger C.P. , Peschke P. , Sanchez-Brandelik R. , Scholz M. , and Debus J. (2006). ‘Radiation tolerance of the rat spinal cord after 6 and 18 fractions of photons and carbon ions: experimental results and clinical implications,’ Int. J. Radiat. Oncol. Biol. Phys. 66, 1488–1497.

Karger C.P. , Jäkel O. , Palmans H. , and Kanai T. (2010). ‘Dosimetry for ion beam radiotherapy,’ Phys. Med. Biol. 55, R193–R234.

Karger C.P. , Peschke P. , Scholz M. , Huber P.E. , and Debus J. (2013). ‘Relative biological effectiveness of carbon ions in a rat prostate carcinoma in vivo: comparison of 1, 2, and 6 fractions,’ Int. J. Radiat. Oncol. Biol. Phys. 86, 450–455.

Kase Y. , Kanai T. , Matsumoto Y. , Furusawa Y. , Okamoto H. , Asaba T. , Sakama M. , and Shinoda H. (2006a). ‘Microdosimetric measurements and estimation of human cell survival for heavy-ion beams,’ Radiat. Res. 166, 629–638.

Kase Y. , Kanematsu N. , Kanai T. , and Matsufuji N. (2006b). ‘Biological dose calculation with Monte Carlo physics simulation for heavy-ion radiotherapy,’ Phys. Med. Biol. 51, N467–N475.

Kase Y. , Kanai T. , Matsufuji N. , Furusawa Y. , Elsässer T. , and Scholz M. (2007). ‘Biophysical calculation of cell survival probabilities using amorphous track structure models for heavy-ion irradiation,’ Phys. Med. Biol. 53, 37.

Kase Y. , Kanai T. , Sakama M. , Tameshige Y. , Himukai T. , Nose H. , and Matsufuji N. (2011). ‘Microdosimetric approach to NIRS-defined biological dose measurement for carbon-ion treatment beam,’ J. Radiat. Res. 52, 59–68.

Kato S. , Ohno T. , Tsujii H. , Nakano T. , Mizoe J.E. , Kamada T. , Miyamoto T. , Tsuji H. , Kato H. , Yamada S. , Kandatsu S. , Yoshikawa K. , Ezawa H. , and Suzuki M. Working Group of the Gynecological Tumor. (2006). ‘Dose escalation study of carbon ion radiotherapy for locally advanced carcinoma of the uterine cervix,’ Int. J. Radiat. Oncol. Biol. Phys. 65, 388–397.

Katz R. , Ackerson B. , Homayoonfar M. , and Sharma S.C. (1971). ‘Inactivation of cells by heavy ion bombardment,’ Radiat. Res. 47, 402–425.

Keall P. (2004). ‘4-dimensional computed tomography imaging and treatment planning,’ Semin. Radiat. Oncol. 14, 81–90.

Keall P. (2011). ‘Locating and targeting moving tumors with radiation beams,’ Front. Radiat. Ther. Oncol. 43, 118–131.

Keall P.J. , Kini V.R. , Vedam S.S. , and Mohan R. (2001). ‘Motion adaptive x-ray therapy: A feasibility study,’ Phys. Med. Biol. 46, 1–10.

Keall P.J. , Siebers J.V. , Joshi S. , and Mohan R. (2004). ‘Monte Carlo as a four-dimensional radiotherapy treatment-planning tool to account for respiratory motion,’ Phys. Med. Biol. 49, 3639–3648.

Kellerer A.M. , and Rossi H.H. (1974). ‘The theory of dual radiation action,’ Curr. Top. Radiat. Res. Q.85–158.

Kim J. , Park Y.K. , Sharp G. , Busse P. , and Winey B. (2017). ‘Water equivalent path length calculations using scatter-corrected head and neck CBCT images to evaluate patients for adaptive proton therapy,’ Phys. Med. Biol. 62, 59–72.

Kirkpatrick J.P. , van der Kogel A.J. , and Schultheiss T.E. (2010). ‘Radiation dose-volume effects in the spinal cord,’ Int. J. Radiat. Oncol. Biol. Phys. 76, S42–S49.

Kitagawa A. , Yamada S. , Kohno T. , Murakami T. , Muramatsu M. , Noda K. , Ogawa H. , Sato Y. , Yamada T. , Yoshizawa J. , Fu S. , Sekiguchi M. , Ohshiro Y. , Hattori T. , Shibuya S. , Matsushita H. , Sawada K. , and Morishita O. (1994). ‘Development of the National Institute of Radiological Sciences electron-cyclotron-resonance ion-source for the heavy-ion medical accelerator in Chiba,’ Rev. Sci. Instrum. 65, 1087–1089.