1. Introduction

Amaldi U. and Kraft G. (2009). Hadrontherapy: cancer treatment with proton and carbon beams. In Lemoigne Y. and Caner A. (eds.)Radiotherapy and Brachytherapy, pp. 165–171. Springer.

Archambeau J.O. , Bennett G.W. , Levine G.S. , Cowen R. and Akanuma A. (1974). Proton radiation therapy. Radiology, 110, 445–457.

Badano L. , Crescenti M. , Holy P. , Maier A. , Knaus P. , Bryant P. , Benedikt M. , Pullia M. and Rossi S. (1999). Proton-Ion Medical Machine Study (PIMMS), 1.

Bentzen S.M. , Dörr W. , Gahbauer R. , Howell R.W. , Joiner M.C. , Jones B. , Jones D.T. , van der Kogel A.J. , Wambersie A. and Whitmore G. (2012). Bioeffect modeling and equieffective dose concepts in radiation oncology–terminology, quantities and units. Radiother. Oncol., 105, 266–268.

Blakely E.A. , Ngo F.Q.H. , Curtis S.B. and Tobias C.A. (1984). Heavy-ion radiobiology – cellular studies. Adv. Radiat. Biol., 11, 295–389.

Blakely E. , Tobias C. , Ludewigt B. and Chu W. (1986). ‘Some physical and biological properties of light ions,’ pp. 19–41 in Proc. Fifth PTCOG Meeting and the International Workshop on Biomedical Accelerators.

Bohm D. and Foldy L.L. (1947). Theory of the synchro-cyclotron. Phys. Rev., 72, 649–661.

Bragg W.H. and Kleeman R. (1904). LXXIV. On the ionization curves of radium. Lond. Edinb. Dubl. Phil. Mag. J. Sci., 8, 726–738.

Bryant P. , Weisser L. , Badano L. , Borri G. , Crescenti M. , Holy P. , Reimoser S. , Maier A. , Knaus P. and Pavlovic M. (2000). Proton-Ion Medical Machine Study (PIMMS), 2.

Castro J.R. , Chen G.T. , Pitluck S. , Cartigny A. , Phillips T.L. , Saunders W.M. , Collier M.J. , Woodruff K.H. , Friedman M. and Austin-Seymour M. (1983). Helium charged-particle radiotherapy of locally advanced carcinoma of the esophagus, stomach, and biliary tract. Am. J. Clin. Oncol., 6, 629–737.

Castro J.R. (1993). Heavy ion therapy: the BEVALAC epoch. In Amaldi U. and Larsson B. (eds.)Hadrontherapy in Oncology: Proceedings of the First International Symposium on Hadrontherapy, pp. 208–216. Elsevier Science, Como, Italy.

Castro J.R. (1995). ‘Future research strategy for heavy ion radiotherapy,’ Progress in Radio-Oncology. ed. Kogelnik HD 643–648.

Castro J.R. (1997). Clinical programs: a review of past and existing hadron protocols. In Advances in Hadron Therapy. Elsevier Science, Amsterdam, The Netherlands.

Castro J.R. , Linstadt D.E. , Bahary J.P. , Petti P.L. , Daftari I. , Collier J.M. , Gutin P.H. , Gauger G. and Phillips T.L. (1994). Experience in charged particle irradiation of tumors of the skull base: 1977–1992. Int. J. Radiat. Oncol. Biol. Phys., 29, 647–655.

Chu W. , Ludewigt B. and Renner T. (1993). Instrumentation for treatment of cancer using proton and light‐ion beams. Rev. Sci. Instrum., 64, 2055–2122.

Combs S.E. , Jakel O. , Haberer T. and Debus J. (2010). Particle therapy at the Heidelberg Ion Therapy Center (HIT) – integrated research-driven university-hospital-based radiation oncology service in Heidelberg, Germany. Radiother. Oncol., 95, 41–44.

Eickhoff H. , Haberer T. , Kraft G. , Krause U. , Richter M. , Steiner R. and Debus J. (1999). The GSI Cancer Therapy Project. Strahlenther. Onkol., 175, 21–24.

Gol'din L. , Dzhelepov V. , Lomanov M. , Savchenko O. and Khoroshkov V.S. (1973). Application of high-energy heavy charged particles in medicine. Phys.-Uspekhi, 16, 402–413.

Goldhaber A.S. and Heckman H.H. (1978). High-energy interactions of nuclei. Annu. Rev. Nucl. Part. Sci., 28, 161–205.

Graffman S. , Brahme A. and Larsson B. (1985). Proton radiotherapy with the Uppsala cyclotron. Experience and plans. Strahlentherapie, 161, 764–770.

Grunder H. , Hartsough W. and Lofgren E. (1971). Acceleration of heavy ions at the Bevatron. Science, 174, 1128–1129.

Gunzert-Marx K. , Schardt D. and Simon R.S. (2004). Fast neutrons produced by nuclear fragmentation in treatment irradiations with 12C beam. Radiat. Prot. Dosimetry, 110, 595–600.

Heilbron J.L. and Seidel R.W. (1989) Lawrence and His Labroratory: A History of the Lawrence Berkeley Laboratory. University of California Press, Berkeley.

IAEA (2007). International Atomic Energy Agency. Dose Reporting in Ion Beam Therapy. IAEA TECDOC-1560 (International Atomic Energy Agency, Vienna).

ICRU (1979). International Commission on Radiation Units and Measurements. Quantitative Concepts and Dosimetry in Radiobiology. ICRU Report 30 (International Commission on Radiation Units and Measurements, Bethesda, MD).

ICRU (1986). International Commission on Radiation Units and Measurements. The Quality Factor in Radiation Protection. ICRU Report 40 (International Commission on Radiation Units and Measurements, Bethesda, MD).

ICRU (2007). International Commission on Radiation Units and Measurements. Prescribing, Recording, and Reporting Proton-Beam Therapy. ICRU Report 78, J. ICRU Vol. 7(2) (Oxford University Press, Oxford).

ICRU (2016). International Commission on Radiation Units and Measurements. Key Data for Ionizing-Radiation Dosimetry: Measurement Standards and Applications. ICRU Report 90, J. ICRU Vol. 14(1) (Oxford University Press, Oxford).

Kohno R. , Kanematsu N. , Yusa K. and Kanai T. (2004). Experimental evaluation of analytical penumbra calculation model for wobbled beams. Med. Phys., 31, 1153–1157.

Larsson B. (1961). Pre-therapeutic physical experiments with high energy protons. Br. J. Radiol., 34, 143–151.

Larsson B. (1967). Radiological properties of beams of high-energy protons. Radiat. Res. Suppl., 7, 304–311.

Lawrence J.H. (1957). Proton irradiation of the pituitary. Cancer, 10, 795–798.

Levy R.P. , Blakely E.A. , Chu W.T. , Coutrakon G.B. , Hug E.B. , Kraft G. , Tsujii H. , McDaniel F.D. and Doyle B.L. (2009). The current status and future directions of heavy charged particle therapy in medicine. pp. 410–425 in AIP Conference Proceedings, (AIP).

Lillis-Hearne P.K. and Castro J.R. (1995). Indications for heavy ions-Lessons from Berkeley. In Linz V. (ed.)Ion Beams in Tumour Therapy, pp. 133–141. Chapman & Hall.

Linz U. (2011) Ion Beam Therapy: Fundamentals, Technology, Clinical Applications. Springer Science & Business Media.

Llacer J. , Tobias C.A. , Holley W.R. and Kanai T. (1984). On-line characterization of heavy-ion beams with semiconductor detectors. Med. Phys., 11, 266–278.

McCaslin J.B. , LaPlant P.R. , Smith A.R. , Swanson W.P. and Thomas R.H. (1985). Neutron production by Ne and Si ions on a thick Cu target at 670 MeV· A with application to radiation protection. IEEE T. Nucl. Sci., 32, 3104–3106.

Mori S. , Shibayama K. , Tanimoto K. , Kumagai M. , Matsuzaki Y. , Furukawa T. , Inaniwa T. , Shirai T. , Noda K. , Tsuji H. and Kamada T. (2012). First clinical experience in carbon ion scanning beam therapy: retrospective analysis of patient positional accuracy. J. Radiat. Res., 53, 760–768.

Murakami M. , Demizu Y. , Niwa Y. , Miyawaki D. , Terashima K. , Arimura T. , Mima M. , Nagayama S. , Maeda T. and Baba M. (2009). Current status of the HIBMC and results of representative diseases. pp. 400–415 in AIP Conference Proceedings, (AIP).

Noda K. , Furukawa T. , Fujimoto T. , Inaniwa T. , Iwata Y. , Kanai T. , Kanazawa M. , Minohara S. , Miyoshi T. , Murakami T. , Sano Y. , Sato S. , Takada E. , Takei Y. , Torikai K. and Torikoshi M. (2008). New treatment facility for heavy-ion cancer therapy at HIMAC. Nucl. Instrum. Methods Phys. Res. B, 266, 2182–2185.

Orecchia R. , Rossi S. , Fossati P. , McDaniel F.D. and Doyle B.L. (2009a) Indications of carbon ion therapy at CNAO. pp. 399–404 in AIP Conference Proceedings, (AIP).

Orecchia R. , Fossati P. and Rossi S. (2009b) The national center for oncological hadron therapy: status of the project and future clinical use of the facility. Tumori, 95, 169–176.

Particle Therapy Co-Operative Group (PTCOG). Patient statistics per end of 2015. https://www.ptcog.ch/archive/patient_statistics/Patientstatistics-updateDec2015.pdf (23 January 2017, date last assessed).

Phillips M.H. , Frankel K.A. , Lyman J.T. , Fabrikant J.I. and Levy R.P. (1990). Comparison of different radiation types and irradiation geometries in stereotactic radiosurgery. Int. J. Radiat. Oncol. Biol. Phys., 18, 211–220.

Pirruccello M. and Tobias C.A. (1980) Biological and Medical Research with Accelerated Heavy Ions at the Bevalac, 1977–1980. Biology and Medicine Division, Lawrence Berkeley Laboratory, University of California.

Raju M. (1995). The history of ion beam therapy. In Ion Beams in Tumor Therapy, pp. 3–9. Chapman & Hall.

Schulz-Ertner D. , Nikoghosyan A. , Thilmann C. , Haberer T. , Jäkel O. , Karger C. , Kraft G. , Wannenmacher M. and Debus J. (2004). Results of carbon ion radiotherapy in 152 patients. Int. J. Radiat. Oncol. Biol. Phys., 58, 631–640.

Slater J.M. , Archambeau J.O. , Miller D.W. , Notarus M.I. , Preston W. and Slater J.D. (1992). The Proton Treatment Center at Loma-Linda-University-Medical-Center – rationale for and description of its development. Int. J. Radiat. Oncol., 22, 383–389.

Slater J.D. , Slater J.M. and Schulte R.W. (1995). Proton beam therapy at Loma Linda University Medical Center: clinical experience of the first four years. Progress Radio-oncol., 673–679.

Suit H.D. and Chu W. (2008). History of charged particle radiotherapy. In DeLaney T.F. and Kooy H.M. (eds.)Proton and Charged Particle Radiotherapy, pp. 1–7. Lippincott Williams & Wilkins.

Suit H.D. , Goitein M. , Tepper J. , Koehler A.M. , Schmidt R.A. and Schneider R. (1975). Exploratory study of proton radiation-therapy using large field techniques and fractionated dose schedules. Cancer, 35, 1646–1657.

Tobias C.A. (1973). Pretherapeutic investigations with accelerated heavy ions. Radiology, 108, 145–158.

Tobias C. and Segre E. (1946). High energy carbon nuclei. Phys. Rev., 70, 89.

Tobias C. and Todd P. (1967). Radiobiology and radiotherapy. Natl. Cancer Inst. Monogr., 24, 1–21.

Tobias C.A. , Anger H.O. and Lawrence J.H. (1952). Radiological use of high energy deuterons and alpha particles. Am. J. Roentgenol., 67, 1–27.

Tobias C. , Lawrence J. , Born J. , McCombs R. , Roberts J. , Anger H. , Low-Beer B. and Huggins C. (1958). Pituitary irradiation with high-energy proton beams a preliminary report. Cancer Res., 18, 121–134.

Tobias C.A. , Lyman J.T. , Chatterjee A. , Howard J. , Maccabee H.D. , Raju M.R. , Smith A.R. , Sperinde J.M. and Welch G.P. (1971). Radiological physics characteristics of the extracted heavy ion beams of the bevatron. Science, 174, 1131–1134.

Todd P. , Schroy C.B. , Vosburgh K.G. and Schimmerling W. (1971). Spatial distribution of biological effect in a 3.9-Gev nitrogen ion beam. Science, 174, 1127–1128.

Tsujii H. (2010). Overview of carbon ion radiotherapy at NIRS. In Proc. of the II NIRS-CNAO Joint Symposium on Hadrontherapy, pp.1–9. NIRS-M-229, Pavia, Italy.

Tsujii H. and Kamada T. (2012). A review of update clinical results of carbon ion radiotherapy. Jpn. J. Clin. Oncol., 42, 670–685.

Tsujii H. , Mizoe J. , Kamada T. , Baba M. , Tsuji H. , Kato H. , Kato S. , Yamada S. , Yasuda S. , Ohno T. , Yanagi T. , Imai R. , Kage K. , Kato H. , Hara R. , Hasegawa A. , Nakajima M. , Sugane N. , Tamaki N. , Takagi R. , Kandatsu S. , Yoshikawa K. , Kishimoto R. and Miyamoto T. (2007). Clinical results of carbon ion radiotherapy at NIRS. J. Radiat. Res. (Tokyo), 48, A1–A13.

Wambersie A. , Deluca P.M. , Andreo P. and Hendry J.H. (2004). “Light” or “heavy” ions: a debate of terminology?Radiother. Oncol., 73, iiii.

White M.G. , Isaila M. , Prelec K. and Allen H.L. (1971). Acceleration of nitrogen ions to 7.4 gev in the princeton particle accelerator. Science, 174, 1121–1123.

Wilson R.R. (1946). Radiological use of fast protons. Radiology, 47, 487–491.

Wilson R. (1997). Foreword to the second international symposium on hadrontherapy. In Amaldi U. , Larsson B. and Lemoigne Y. (eds.)Advances in Hadrontherapy, Excerpta Medica, International Congress Series. Elsevier.

Yamada S. , Yusa K. , Tashiro M. and Torikai K. (2009). p. 170 in Proc. of the NIRS-Etoile Joint Symposium 2009 on Carbon Ion Radiotherapy, (Lyon, France, 2009 (unpublished)).

Yonai S. , Matsufuji N. , Kanai T. , Matsui Y. , Matsushita K. , Yamashita H. , Numano M. , Sakae T. , Terunuma T. , Nishio T. , Kohno R. and Akagi T. (2008). Measurement of neutron ambient dose equivalent in passive carbon-ion and proton radiotherapies. Med. Phys., 35, 4782–4792.

Yonai S. , Kase Y. , Matsufuji N. , Kanai T. , Nishio T. , Namba M. and Yamashita W. (2010). Measurement of absorbed dose, quality factor, and dose equivalent in water phantom outside of the irradiation field in passive carbon-ion and proton radiotherapies. Med. Phys., 37, 4046–4055.

Zhang H. , Li S. , Wang X.H. , Li Q. , Wei S.H.G.L.Y. , Zhao W.P. , Hu Z.G. , Mao R.S. , Xu H.S. , Zhang Q.N. , Yue Y.J. , Tian Z.Z. , Ran J.T. , Xiao G.Q. and Zhan W.L. (2011). Therapeutic techniques applied in the heavy-ion therapy at IMP. Nucl. Instrum. Methods Phys. Res. B, 269, 664–670.