Immune Deficiency in Children

Abstract

Recurrent viral respiratory infections in childhood are extremely common and GPs are regularly asked by concerned parents whether there is ‘something wrong’ with their child's immune system. The vast majority of children have normal immune function. There is, however, a small subgroup of children who have problems with their immune system. Early recognition of these children and timely referral for specialist assessment and treatment can profoundly affect their prognosis. The GP therefore has an important role in not only identifying those children for whom further investigation is warranted, but also in appropriately reassuring those for whom it is not. This article describes causes of recurrent infections in children and the clinical features which should raise suspicion of immunodeficiency, prompting referral for further assessment.