Zebrafish (Danio rerio) is an important developmental biology and genetic animal model. Its educational use provides students with the opportunity for research-based learning, leading to the high-quality integration of theoretical knowledge with practical skills. In this study, we explored a didactic approach to teaching developmental biology using zebrafish. We describe the curriculum design and course workflow based on several pedagogical strategies and didactic tools that facilitate teaching effectiveness. Students’ opinions confirm that knowledge is accessible during laboratories and lectures. Moreover, we observed an increasing number of students willing to perform research projects and conduct master’s theses on topics related to developmental biology and model organisms in our department. Issues surrounding the use of animals in research and education are currently a subject of much discussion. Considerable attention is being paid to future animal-free alternatives. The course described here addresses this issue.
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