For more than 60 years, zebrafish have been used in toxicological studies. Due to their transparency, genetic tractability, and compatibility with high-throughput screens, zebrafish embryos are uniquely suited to study the effects of pharmaceuticals and environmental insults on embryonic development, organ formation and function, and reproductive success. This special issue of Zebrafish highlights the ways zebrafish are used to investigate the toxic effects of endocrine disruptors, pesticides, and heavy metals.
Get full access to this article
View all access options for this article.
References
1.
HaffterP, GranatoM, BrandM, MullinsMC, HammerschmidtM, KaneDA, et al.The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development, 1996; 123:1–36.
2.
DrieverW, Solnica-KrezelL, SchierAF, NeuhaussSC, MalickiJ, StempleDL, et al.A genetic screen for mutations affecting embryogenesis in zebrafish. Development, 1996; 123:37–46.
3.
BattleHI, HisaokaKK. Effects of ethyl carbamate (urethan) on the early development of the teleost Brachydanio rerio. Cancer Res, 1952; 12:334–340.
4.
JonesRW, HuffmanMN. Fish embryos as bio-assay material in testing chemicals for effects on cell division and differentiation. Trans Am Microsc Soc, 1957; 76:177–183.
5.
PadillaS, CorumD, PadnosB, HunterDL, BeamA, HouckKA, et al.Zebrafish developmental screening of the ToxCast Phase I chemical library. Reprod Toxicol, 2012; 33:174–187.
6.
TruongL, ReifDM, St MaryL, GeierMC, TruongHD, TanguayRL. Multidimensional in vivo hazard assessment using zebrafish. Toxicol Sci, 2014; 137:212–233.
7.
SaleyA, HessM, MillerK, HowardD, King-HeidenTC. Cardiac toxicity of triclosan in developing zebrafish. Zebrafish, 2016; 13:399–404.
8.
HallauerJ, GengX, YangH-C, ShenJ, TsaiK-J, LiuZ. The effect of chronic arsenic exposure in zebrafish. Zebrafish, 2016; 13:405–412.
9.
BakerBB, YeeJS, MeyerDN, YangD, BakerTR. Histological and transcriptomic changes in male zebrafish testes due to early life exposure to low level 2,3,7,8-tetrachlorodibenzo-p-dioxin. Zebrafish, 2016; 13:413–423.
10.
CarmosiniN, GrandstrandS, King-HeidenT. Developmental toxicity of triclosan in the presence of dissolved organic carbon: moving beyond standard acute toxicity assays to understand ecotoxicological risk. Zebrafish, 2016; 13:424–431.
11.
VelasquesRR, SandriniJZ, da RosaCE. Roundup® in zebrafish: effects on oxidative balance and gene expression. Zebrafish, 2016; 13:432–441.
12.
Ku-CenturionM, Gonzalez-MarinB, Calderon-EzquerroMC, Martinez-ValenzuelaMC, MaldonadoE, Calderon-SeguraME. DNA damage assessment in zebrafish embryos exposed to Monceren® 250 SC fungicide using the alkaline comet assay. Zebrafish, 2016; 13:442–448.
13.
ConsigliV, GuarientiM, BiloF, BenassiL, DeperoLE, BontempiE, PrestaM. Evaluation of the biotoxicity of tree wood ashes in zebrafish embryos. Zebrafish, 2016; 13:449–455.
14.
BerryJP, RoyU, Jaja-ChimedzaA, SanchezK, MatysikJ, AliaA. High-resolution magic angle spinning nuclear magnetic resonance of intact zebrafish embryos detects metabolic changes following exposure to teratogenic polymethoxyalkenes from algae. Zebrafish, 2016; 13:456–465.
15.
MakarovaK, SiudemP, ZawadaK, KurkowiakJ. Screening of toxic effects of bisphenol A and products of its degradation: zebrafish (Danio rerio) embryo test and molecular docking. Zebrafish, 2016; 13:466–474.
16.
KyzarEJ, KalueffAV. Exploring hallucinogen pharmacology and psychedelic medicine with zebrafish models. Zebrafish, 2016; 13:379–390.
17.
LovelyCB, FernandesY, EberhartJK. Fishing for fetal alcohol spectrum disorders: zebrafish as a model for ethanol teratogenesis. Zebrafish, 2016; 13:391–398.
