Pet and feeder rodents are one of the main sources of emerging infectious diseases. These rodents are purchased from pet shops, breeders, and online. Consequently, some of these rodents may subtly transmit diseases as they may be asymptomatic to certain pathogens.
Materials and Methods:
We systematically searched four academic databases viz. Google Scholar, PubMed, Web of Science, and Scopus to determine zoonotic pathogens associated with pet and feeder rodents globally. Our searches were performed in R statistical software using the packages “metagear” and “revtool”.
Results:
We found 62 studies reporting on zoonotic pathogens between 1973 and 2022 from 16 countries representing 4 continents, namely Africa, Europe, Asia, and North America. The review identified 30 zoonotic pathogens isolated from pet and feeder rodents, including the African pygmy mouse (Mus minutoides), brown rat (Rattus norvegicus), and the house mouse (Mus musculus). The greatest number of pathogens was reported from the United States, followed by Togo and the United Kingdom. Bacterial pathogens were the most prevalent. However, the Seoul virus and rat bite fever (Streptobacillus moniliformis) were the most studied pathogens, found in more than one country, with reported outbreak cases. Most of the zoonotic pathogens were isolated from rodents acquired from pet shops.
Conclusions:
We recommend that pet and feeder rodents purchased from pet shops should be regularly screened for potential zoonotic pathogens as some of these animals may not show clinical signs of the illness. There is also a critical need to develop strict regulations and policies, especially in underdeveloped and developing regions for an effective surveillance process, which will include early detection, rapid response, and control of zoonotic diseases globally.
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References
1.
BakerSE, CainR, Van KesterenF, et al.Rough trade: Animal welfare in the global wildlife trade. BioScience, 2013; 63(12):928–938; doi: 10.1525/bio.2013.63.12.6
2.
BernardSM, AndersonSA. Qualitative assessment of risk for monkeypox associated with domestic trade in certain animal species, United States. Emerg Infect Dis, 2006; 12(12):1827–1833; doi: 10.3201/eid1212.060454
3.
Bezerra-SantosMA, Mendoza-RoldanJA, ThompsonRA, et al.Illegal wildlife trade: A gateway to zoonotic infectious diseases. Trends Parasitol, 2021; 37(3):181–184; doi: 10.1016/j.pt.2020.12.005
4.
BushER, BakerSE, MacdonaldDW. Global trade in exotic pets 2006–2012. Conserv Biol, 2014; 28(3):663–676; doi: 10.1111/cobi.12240
5.
CampeH, ZimmermannP, GlosK, et al.Cowpox virus transmission from pet rats to humans, Germany. Emerg Infect Dis, 2009; 15(5):777–780; doi: 10.3201/eid1505.090159
6.
CartwrightEJ, NguyenT, MellusoC, et al.A multistate investigation of antibiotic-resistant Salmonella enterica serotype I 4,[5], 12: i:-infections as part of an international outbreak associated with frozen feeder rodents. Zoonoses Public Health, 2016; 63(1):62–71; doi: 10.1111/zph.12205
7.
Centers for Disease Control and Prevention. Update: Multistate outbreak of monkeypox—Illinois, Indiana, Kansas, Missouri, Ohio, and Wisconsin, 2003. MMWR Morb Mortal Wkly Rep, 2003; 52(24):561–564.
8.
Centers for Disease Control and Prevention. US Outbreaks of Zoonotic Diseases Spread between Animals and People; 2022. Available from: https://www.cdc.gov/healthypets/outbreaks.html [Last accessed: February12, 2022].
CollisAH, FeniliRN. The Modern US Reptile Industry. Georgetown Economic Services: Washington, DC; 2011.
11.
DamborgP, BroensEM, ChomelBB, et al.Bacterial zoonoses transmitted by household pets: state-of-the-art and future perspectives for targeted research and policy actions. J Comp Pathol, 2016; 155(1):S27–S40; doi: 10.1016/j.jcpa.2015.03.004
12.
D'CruzeN, BatesJ, AssouD, et al.A preliminary assessment of bacteria in “ranched” ball pythons (Python regius), Togo, West Africa. Nat Conserv, 2020; 39:73–86; doi: 10.3897/natureconservation.39.48599
13.
DrewsC. Wild animals and other pets kept in Costa Rican households: incidence, species and numbers. Soc Anim, 2001; 9(2):107–126; doi: 10.1163/156853001753639233
14.
DucournauC, Ferrier-RembertA, FerrarisO, et al.Concomitant human infections with 2 cowpox virus strains in related cases, France, 2011. Emerg Infect Dis, 2013; 19(12):1996–1999; doi: 10.3201/eid1912.130256
15.
EdisonL, KnustB, PetersenB, et al.Trace-forward investigation of mice in response to lymphocytic choriomeningitis virus outbreak. Emerg Infect Dis, 2014; 20(2):291–295; doi: 10.3201/eid2002.130861
16.
ESRI. ArcGIS Desktop: Release 10.6. Environmental Systems Research Institute: Redlands, CA; 2022.
17.
FerreiraMN, ElliottW, KronerRG, et al.Drivers and causes of zoonotic diseases: An overview. Parks, 2021; 27(27):15–24.
18.
FullerCC, JawahirSL, LeanoFT, et al.A multi-state Salmonella Typhimurium outbreak associated with frozen vacuum-packed rodents used to feed snakes. Zoonoses Public Health, 2008; 55(8–10):481–487; doi: 10.1111/j.1863-2378.2008.01118.x
19.
GaastraW, BootR, HoHT, et al.Rat bite fever. Vet Microbiol, 2009; 133(3):211–228; doi: 10.1016/j.vetmic.2008.09.079
20.
GippetJM, BertelsmeierC. Invasiveness is linked to greater commercial success in the global pet trade. Proc Natl Acad Sci U S A, 2021; 118(14):e2016337118; doi: 10.1073/pnas.2016337118
21.
GrantRA, MontroseVT, WillsAP. ExNOTic: Should we be keeping exotic pets?. Animals, 2017; 7:47; doi: 10.3390/ani7060047
22.
HalsbyKD, WalshAL, CampbellC, et al.Healthy animals, healthy people: Zoonosis risk from animal contact in pet shops, a systematic review of the literature. PLoS One, 2014; 9(2):e89309; doi: 10.1371/journal.pone.0089309
23.
HänninenC.Why Does My Neighbor's Labradoodle Have Eight Million Followers on Instagram?: Exploring Pets as Social Media Influencers [Thesis (MSc)]. Hanken School of Economics: Helsinki, Finland; 2021.
24.
HarkerKS, LaneC, De PinnaE, AdakGK. An outbreak of Salmonella Typhimurium DT191a associated with reptile feeder mice. Epidemiol Infect, 2011; 139(8):1254–1261; doi: 10.1017/S0950268810002281
25.
HarringtonL, MacdonaldD, D'CruzeN. Popularity of pet otters on YouTube: evidence of an emerging trade threat. Nat Conserv, 2019; 36:17–45; doi: 10.3897/natureconservation.36.33842
26.
HolmbergRJ, TlustyMF, FutomaE, et al.The 800-pound grouper in the room: Asymptotic body size and invasiveness of marine aquarium fishes. Mar Policy, 2015; 53:7–12; doi: 10.1016/j.marpol.2014.10.024
27.
HönlingerB, HuemerHP, RomaniN, et al.Generalized cowpox infection probably transmitted from a rat. Br J Dermatol, 2005; 153(2):451–453; doi: 10.1111/j.1365-2133.2005.06731.x
28.
KanagarajahS, WaldramA, DolanG, et al.Whole genome sequencing reveals an outbreak of Salmonella Enteritidis associated with reptile feeder mice in the United Kingdom, 2012–2015. Food Microbiol, 2018; 71:32–38; doi: 10.1016/j.fm.2017.04.005
29.
KerinsJL, KoskeSE, KazmierczakJ, et al.Outbreak of Seoul virus among rats and rat owners—United States and Canada, 2017. MMWR Morb Mortal Wkly Rep, 2018; 67(4):131–134; doi: 10.1558/5/mmwr.mm6704a5
30.
KieswetterS. The motivations behind obtaining exotic pets: A discussion paper; 2017. Available from: https://www.zoocheck.com/wp-content/uploads/2017/10/The-Motivations-Behind-Obtaining-Exotic-Pets_September-2017.pdf [Last accessed: February12, 2022].
31.
KnustB, BrownS, deSt. Maurice A, et al. Seoul virus infection and spread in United States home-based ratteries: Rat and human testing results from a multistate outbreak investigation. J Infect Dis, 2020; 222(8):1311–1319; doi: 10.1093/infdis/jiaa307
32.
LajeunesseMJ. Facilitating systematic reviews, data extraction and meta-analysis with the metagear package for R. Methods Ecol Evol, 2016; 7(3):323–330; doi: 10.1111/2041-210X.12472
33.
LankauEW, SinclairJR, SchroederBA, et al.Public health implications of changing rodent importation patterns–United States, 1999–2013. Transbound Emerg Dis, 2017; 64(2):528–537; doi: 10.1111/tbed.12396
34.
LeeKM, McReynoldsJL, FullerCC, et al.Investigation and characterization of the frozen feeder rodent industry in Texas following a multi-state Salmonella Typhimurium outbreak associated with frozen vacuum-packed rodents. Zoonoses Public Health, 2008; 55(8–10):488–496; doi: 10.1111/j.1863-2378.2008.01165.x
35.
LockwoodJL, WelbourneDJ, RomagosaCM, et al.When pets become pests: The role of the exotic pet trade in producing invasive vertebrate animals. Front Ecol Environ, 2019; 17(6):323–330; doi: 10.1002/fee.2059
36.
MignardS, Aubry-RozierB, de MontclosM, et al.Pet-rat bite fever and septic arthritis: Molecular identification of Streptobacillus moniliformis. Med Mal Infect, 2007; 37(5):293–294; doi: 10.1016/j.medmal.2006.11.005
37.
MoherD, LiberatiA, TetzlaffJ, et al.Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement (Chinese edition). Chin J Integr Med, 2009; 7(9):889–896; doi: 10.7326/0003-4819-151-4-200908180-00135
38.
MoorhouseTP, BalaskasM, D'CruzeNC, et al.Information could reduce consumer demand for exotic pets. Conserv Lett, 2017; 10(3):337–345; doi: 10.1111/conl.12270
39.
MoriM, BourhyP, Le GuyaderM, et al.Pet rodents as possible risk for leptospirosis, Belgium and France, 2009 to 2016. Euro Surveill, 2017; 22(43):16-00792; doi: 10.2807/1560-7917.ES.2017.22.43.16-00792
40.
MoshobaneMC, NnzeruLR, NelukaloK, et al.Patterns of permit requests and issuance for regulated alien and invasive species in South Africa for the period 2015-2018. Afr J Ecol, 2020; 58(3):514–528; doi: 10.1111/aje.12720
41.
NaickerPR. The impact of climate change and other factors on zoonotic diseases. Arch Clin Microbiol, 2011; 2(2):226; doi: 10:3823/226
42.
PattersonC. Pet Rats. John Alexander Enterprises, Inc.: Jacksonville, FL; 2006.
43.
PavlinBI, SchloegelLM, DaszakP. Risk of importing zoonotic diseases through wildlife trade, United States. Emerg Infect Dis, 2009; 15(11):1721–1726; doi: 10.3201/eid1511.090467
44.
PeesM, RabschW, PlenzB, et al.Evidence for the transmission of Salmonella from reptiles to children in Germany, July 2010 to October 2011. Euro Surveill, 2013; 18(46):20634; doi: 10.2807/1560-7917.ES2013.18.46.20634
45.
PimentelD, LachL, ZunigaR, et al.Environmental and economic costs of nonindigenous species in the United States. BioScience, 2000; 50(1):53–65; doi: 10.1641/0006-3568(2000)050[0053:EAECON]2.3.CO;2
46.
PlotogeaA, TaylorM, ParaynoA, et al. Human Salmonella enteritidis illness outbreak associated with exposure to live mice in British Columbia, Canada, 2018–2019. Zoonoses Public Health, 2022; 69(7):856–863; doi: 10.1111/zph.12978
47.
PrapasarakulN, PulsrikarnC, VasaruchapongT, et al.Salmonella serovar distribution in cobras (Naja kaouthia), snake-food species, and farm workers at Queen Saovabha Snake Park, Thailand. Vet Diagn Invest, 2012; 24(2):288–294; doi: 10.1177/1040638711434110
48.
R Core Team. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing: Vienna, Austria; 2022.
49.
RahmanMT, SoburMA, IslamMS, et al.Zoonotic diseases: Etiology, impact, and control. Microorganisms, 2020; 8(9):1405; doi: 10.3390/microorganisms8091405
50.
ReaserJK, MeyersNM. Habitattitude: Getting a backbone about the pet release pathway. Managing Vertebrate Invasive Species, 2007; 40:63–71.
51.
ShivambuN, ShivambuTC, DownsCT. Survey of non-native small mammals traded in South Africa. Afr J Ecol, 2022; 60(3):456–466; doi: 10.1111/aje.12999
52.
ShvartsblatS, KochieM, HarberP, et al.Fatal rat bite fever in a pet shop employee. Am J Ind Med, 2004; 45(4):357–360; doi: 10.1002/ajim.10359
53.
SmithA, WhitfieldY. Household Pets and Zoonoses. National Collaborating Centre for Environmental Health; 2012. Available from: http://www.ncceh.ca/sites/default/files/Household_Pets_Zoonoses_Jan_2012.pdf [Last accessed: August12, 2022].
54.
Sterneberg-Van der MaatenT, TurnerD, Van TilburgJ, et al.Benefits and risks for people and livestock of keeping companion animals: Searching for a healthy balance. J Comp Pathol, 2016; 155(1):S8–S17; doi: 10.1016/j.jcpa.2015.06.007
55.
StringhamOC, LockwoodJL. Pet problems: Biological and economic factors that influence the release of alien reptiles and amphibians by pet owners. J Appl Ecol, 2018; 55(6):2632–2640; doi: 10.1111/1365-2664.13237
56.
SwaninkC, ReimerinkJ, GisolfJ, et al.Autochthonous human case of Seoul virus infection, the Netherlands. Emerg Infect Dis, 2018; 24(12): 2158–2163; doi: 10.3201/eid2412.180229
57.
ValdezJW. Using Google trends to determine current, past, and future trends in the reptile pet trade. Animals, 2021; 11(3):676; doi: 10.3390/ani11030676
58.
VarelaK, BrownJA, LiptonB, et al.A review of zoonotic disease threats to pet owners: A compendium of measures to prevent zoonotic diseases associated with non-traditional pets such as rodents and other small mammals, reptiles, amphibians, backyard poultry, and other selected animals. Vector Borne Zoonotic Dis, 2022; 22(6):303–360; doi: 10.1089/vbz.2022.0022
59.
VogelS, SardyM, GlosK, et al.The Munich outbreak of cutaneous cowpox infection: transmission by infected pet rats. Acta Derm Venereol, 2012; 92(2):126–131; doi: 10.2340/00015555-1227
60.
VrbovaL, SivanantharajahS, WaltonR, et al.Outbreak of Salmonella Typhimurium associated with feeder rodents. Zoonoses Public Health, 2018; 65(4):386–394; doi: 10.1111/zph.12442
61.
WarwickC, SteedmanC, JessopM, et al.Exotic pet suitability: Understanding some problems and using a labeling system to aid animal welfare, environment, and consumer protection. J Vet Behav, 2018; 26:17–26; doi: 10.1016/j.jveb.2018.03.015
62.
WeissLM. Zoonotic parasitic diseases: Emerging issues and problems. Int J Parasitol, 2008; 38(11):1209–1210; doi: 10.1016/j.ijpara.2008.05.005
63.
WestgateMJ. revtools: An R package to support article screening for evidence synthesis. Res Synth Methods, 2019; 10(4):606–614; doi: 10.1002/jrsm.1374
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