Restricted accessResearch articleFirst published online 2018-02
Exposure to Rats and Rat-Associated Leptospira and Bartonella Species Among People Who Use Drugs in an Impoverished,Inner-City Neighborhood of Vancouver,Canada
Rat infestations are common, particularly in impoverished, inner-city neighborhoods. However, there has been little research into the nature and consequences of rat exposure in these neighborhoods, particularly in Canada. In this study, we sought to characterize exposure to rats and rat-associated Leptospira interrogans and Bartonella tribocorum, as well as risk factors associated with exposure, in residents (n = 202) of the Downtown Eastside (DTES) neighborhood of Vancouver, Canada. There was no evidence of exposure to rat-associated L. interrogans but 6/202 (3.0%) of participants were exposed to B. tribocorum, which is known to be circulating among DTES rats. We also found that frequent and close rat exposure was common among DTES residents, and that this exposure was particularly associated with injection drug use and outdoor income-generating activities (e.g., drug dealing). These risk factors may be good targets for interventions geared toward effectively reducing rat exposure.
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References
1.
BattersbySA, ParsonsR, WebsterJP. Urban rat infestations and the risk to public health. J Environ Health Res, 2002; 1:4–12.
2.
ChildsJE, McLaffertySL, SadekR, MillerGL, et al.Epidemiology of rodent bites and prediction of rat infestation in New York City. Am J Epidemiol, 1998; 148:78–87.
3.
ComerJA, DiazT, VlahovD, MonterrosoE, et al.Evidence of rodent-associated Bartonella and Rickettsia infections among intravenous drug users from Central and East Harlem, New York City. Am J Trop Med Hyg, 2001; 65:855–860.
4.
ComerJA, FlynnC, RegneryRL, VlahovD, et al.Antibodies to Bartonella species in inner-city intravenous drug users in Baltimore, Md. Arch Intern Med, 1996; 156:2491–2495.
5.
CulbertL, McMartinP. (2015) Downtown eastside: 260 agencies, housing sites crowd downtown eastside. Available at www.vancouversun.com/health/Downtown+Eastside+agencies+housing+sites+crowd+Downtown+Eastside+with+video/9983274/story.html Accessed December20, 2017.
6.
DavisDE. The characteristics of rat populations. Q Rev Biol, 1953; 28:373–401.
7.
de MasiE, VilaçaP, RazzoliniMTP. Environmental conditions and rodent infestation in Campo Limpo district, Sao Paulo municipality, Brazil. Int J Environ Health Res, 2009; 19:1–16.
8.
DeeringKN, RuschM, AmramO, ChettiarJ, et al.Piloting a “spatial isolation” index: The built environment and sexual and drug use risks to sex workers. Int J Drug Policy, 2014; 25:533–542.
9.
FengA, HimsworthCG. The secret life of the city rat: A review of the ecology of urban Norway and black rats (Rattus norvegicus and Rattus rattus). Urban Ecosystem, 2014; 17:149–162.
10.
GermanD, LatkinCA. Exposure to urban rats as a community stressor among low‐income urban residents. J Community Psychol, 2016; 44:249–262.
11.
GundiVAKB, BilleterSA, RoodMP, KosoyMY. Bartonella spp. in rats and zoonoses, Los Angeles, California, USA. Emerg Infect Dis, 2012; 18:631–633.
12.
HimsworthCG, BaiY, KosoyMY, WoodH, et al.An investigation of Bartonella spp., Rickettsia typhi, and Seoul hantavirus in rats (Rattus spp.) from an inner-city neighborhood of Vancouver, Canada: Is pathogen presence a reflection of global and local rat population structure?. Vector Borne Zoonotic Dis, 2015; 15:21–26.
13.
HimsworthCG, BidulkaJ, ParsonsKL, FengAYT, et al.Ecology of Leptospira interrogans in Norway rats (Rattus norvegicus) in an inner-city neighborhood of Vancouver, Canada. PLoS Negl Trop Dis, 2013a; 7:e2270.
14.
HimsworthCG, MillerRR, MontoyaV, HoangL, et al.Carriage of methicillin-resistant Staphylococcus aureus by wild urban Norway rats (Rattus norvegicus). PLoS One, 2014a; 9:e87983.
15.
HimsworthCG, ParsonsKL, JardineC, PatrickDM. Rats, cities, people, and pathogens: A systematic review and narrative synthesis of literature regarding the ecology of rat-associated zoonoses in urban centers. Vector Borne Zoonotic Dis, 2013b; 13:349–359.
16.
HimsworthCG, PatrickDM, MakS, JardineCM, et al.Carriage of Clostridium difficile by wild urban Norway rats (Rattus norvegicus) and black rats (Rattus rattus). Appl Environ Microbiol, 2014b; 80:1299–1305.
17.
JansenA, SchönebergI, FrankC, AlpersK, et al.Leptospirosis in Germany, 1962–2003. Emerg Infect Dis, 2005; 11:1048–1054.
18.
KandelakiG, MalaniaL, BaiY, ChakvetadzeN, et al.Human lymphadenopathy caused by ratborne Bartonella, Tbilisi, Georgia. Emerg Infect Dis, 2016; 22:544–546.
19.
KatzAR, BuchholzAE, HinsonK, ParkSY. Leptospirosis in hawaii, USA, 1999–2008. Emerg Infect Dis, 2011; 17:221–226.
20.
KosoyM, BaiY, SheffK, MorwayC, et al.Identification of Bartonella infections in febrile human patients from Thailand and their potential animal reservoirs. Am J Trop Med Hyg, 2010; 82:1140–1145.
21.
LangtonSD, CowanDP, MeyerAN. The occurrence of commensal rodents in dwellings as revealed by the 1996 English House Condition Survey. J Appl Ecol, 2001; 38:699–709.
22.
LazarusL, ChettiarJ, DeeringK, NabessR, et al.Risky health environments: Women sex workers”struggles to find safe, secure and non-exploitative housing in Canada”s poorest postal code. Soc Sci Med, 2011; 73:1600–1607.
23.
LeiblerJH, ZakhourCM, GadhokeP, GaetaJM. Zoonotic and vector-borne infections among urban homeless and marginalized people in the United States and Europe, 1990–2014. Vector Borne Zoonotic Dis, 2016; 16:435–444.
LindenIA, MarMY, WerkerGR, JangK, et al.Research on a vulnerable neighborhood-the vancouver downtown eastside from 2001 to 2011. J Urban Health, 2013; 90:559–573.
26.
LongC, DeBeckK, FengC, MontanerJ, et al.Income level and drug related harm among people who use injection drugs in a Canadian setting. Int J Drug Policy, 2014; 25:458–464.
27.
MilloyM-J, WoodE, KerrT, HoggB, et al.Increased prevalence of controlled viremia and decreased rates of HIV drug resistance among HIV-positive people who use illicit drugs during a community-wide treatment-as-prevention initiative. Clin Infect Dis, 2016; 62:640–647.
28.
RegierY, O RourkeF, KempfVAJ. Bartonella spp.—A chance to establish one health concepts in veterinary and human medicine. Parasit Vectors, 2016; 9:261.
29.
ReisRB, RibeiroGS, FelzemburghRDM, SantanaFS, et al.Impact of environment and social gradient on Leptospira infection in urban slums. PLoS Negl Trop Dis, 2008; 2:e228.
30.
StrathdeeSA, PatrickDM, CurrieSL, CornelissePG, et al.Needle exchange is not enough: Lessons from the Vancouver injecting drug use study. AIDS, 1997; 11:F59–F65.
31.
WalshMG. Rat sightings in New York City are associated with neighborhood sociodemographics, housing characteristics, and proximity to open public space. PeerJ, 2014; 2:e533.
32.
WoodE, KerrT, SmallW, LiK, et al.Changes in public order after the opening of a medically supervised safer injecting facility for illicit injection drug users. CMAJ, 2004; 171:731–734.
33.
ZilberA-L, PicardeauM, AyralF, ArtoisM, et al.High-resolution typing of Leptospira interrogans strains by multispacer sequence typing. J Clin Microbiol, 2014; 52:564–571.
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