Abstract
Ethanolic extract from seeds of Pterodon polygalaeflorus (Benth) has been shown to possess significant larvicidal activity against the mosquito Aedes aegypti. Bioassay-guided fractionation of the extract led to the isolation and characterization of the know diterpenoid furans 6α-hydroxyvouacapan-7β,17β-lactone (1), 6α,7β-dihydroxyvouacapan- 17β-oic acid (2) and methyl 6α,7β-dihydroxyvouacapan-17β-oate (3). The structures were established from infrared (IR), ultraviolet (UV), 1H–nuclear magnetic resonance (NMR), 13C-NMR, and mass spectral data: full NMR assignments are presented for compounds 1–3 and the diacetyl derivative of 3. Compounds 1–3 exhibited LC50 values of 50.08, 14.69, and 21.76 µg/mL against fourth-instar Aedes aegypti larvae.
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