Reassessing Selenium for the Management of Hashimoto's Thyroiditis: The Selini Shines Bright for Autoimmune Thyroiditis Patients

Abstract

Get full access to this article

View all access options for this article.

References

Koehrle

. Selenium in endocrinology—selenoprotein—related diseases, population studies, and epidemiological evidence. Endocrinology, 2021; 162(2):bqaa228; doi: 10.1210/endocr/bqaa228

Weetman

. An update on the pathogenesis of Hashimoto's thyroiditis. J Endocrinol Investig, 2021; 44(5):883–890

Duntas

. Environmental factors and autoimmune thyroiditis. Nat Clin Pract Endocrinol Metab, 2008; 4(8):454–460; doi: 10.1038/ncpendmet0896

, Wang

, Chen

, et al. Increased incidence of Hashimoto Thyroiditis in selenium deficiency: A prospective 6-year cohort study. J Clin Endocrinol Metab, 2022; 107(9):e3603–e3611; doi:10.1210/clinem/dgac410

Winther

, Wichman

JEM

, Bonnema

, et al. Insufficient documentation for clinical efficacy of selenium supplementation in chronic autoimmune thyroiditis, based on a systematic review and meta-analysis. Endocrine, 2017; 55(2):376–385; doi:10.1007/s12020-016-1098-z

Rayman

. The use of high-selenium yeast to raise selenium status: how does it measure up?. Br J Nutr, 2004; 92(4):557–573

, Feng

, Chen

, et al. Effect of selenium on thyroid autoimmunity and regulatory T cells in patients with Hashimoto's thyroiditis: A prospective randomized-controlled trial. Clin Transl Sci, 2021; 14(4):1390–1402; doi: 10.1111/cts.12993

, Holmgren

. The thioredoxin antioxidant system. Free Radic Biol Med, 2014; 66:75–87; doi: 10.1016/j.freeradbiomed.2013.07.036

Huwiler

, Maissen-Abgottspon

, Stanga

, et al. Selenium supplementation in patients with hashimoto thyroiditis—A systematic review and meta-analysis of randomized clinical trials. Thyroid, 2024; doi: 10.1089/thy.2023.0556

10.

Lamirand

, Pallud-Mothré

, Ramaugé

, et al. Oxidative stress regulates type 3 deiodinase and type 2 deiodinase in cultured rat astrocytes. Endocrinology, 2008; 149(7):3713–3721; doi: 10.1210/en.2007-1462

11.

Larsen

, Winther

, Cramon

, et al. Selenium supplementation and placebo are equally effective in improving quality of life in patients with hypothyroidism. Eur Thyroid J, 2024; ETJ-23-0175; doi: 10.1530/ETJ-23-0175

12.

Basciani

, Porcaro

. Counteracting side effects of combined oral contraceptives through the administration of specific micronutrients. Eur Rev Med Pharmacol Sci, 2022; 26(13):4846–4862; doi: 10.26355/eurrev_202207_29210

13.

Watanabe

, Navarro

, Seale

. Intersection between obesity, dietary selenium, and statin therapy in Brazil. Nutrients, 2021; 13(6):2027; doi: 10.3390/nu13062027