Levothyroxine for the Treatment of Subclinical Hypothyroidism in Thyroperoxidase Antibody Negative Pregnant Women: The Jury Is Still Out

Lazarus JH , Bestwick JP , Channon S , Paradice R , Maina A , Rees R , Chiusano E , John R , Guaraldo V , George LM , Perona M , Dall'Amico D , Parkes AB , Joomun M , Wald NJ . 2012. Antenatal thyroid screening and childhood cognitive function. N Engl J Med, 366:493–501.

Casey BM , Thom EA , Peaceman AM , Varner MW , Sorokin Y , Hirtz DG , Reddy UM , Wapner RJ , Thorp JM Jr ., Saade G , Tita AT , Rouse DJ , Sibai B , Iams JD , Mercer BM , Tolosa J , Caritis SN , VanDorsten JP . 2017. Treatment of subclinical hypothyroidism or hypothyroxinemia in pregnancy. N Engl J Med 376:815–825.

Chen J , Zhu J , Huang X , Zhao S , Xiang H , Zhou P , Zhou T , Xu Z . 2022. Subclinical hypothyroidism with negative for thyroid peroxidase antibodies in pregnancy: intellectual development of offspring. Thyroid, 32:449–458.

Nazarpour S , Ramezani Tehrani F , Simbar M , Tohidi M , Minooee S , Rahmati M , Azizi F . 2018. Effects of levothyroxine on pregnant women with subclinical hypothyroidism, negative for thyroid peroxidase antibodies. J Clin Endocrinol Metab, 103:926–935.

Stagnaro-Green A . 2022. Thyroid disease in pregnancy: a touch of clarity. Thyroid, 32:347–348.

Sawka AM , Carty SE , Haugen BR , Hennessey JV , Kopp PA , Pearce EN , Sosa JA , Tufano RP , Jonklaas J . 2018. American Thyroid Association guidelines and statements: past, present, and future. Thyroid, 28:692–706.