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References
1.
Jung
CK
,
Jung
SH
,
Jeon
S
,
Jeong
YM
,
Kim
Y
,
Lee
S
,
Bae
JS
,
Chung
YJ
. 2020 . Risk stratification using a novel genetic classifier including PLEKHS1 promoter mutations for differentiated thyroid cancer with distant metastasis . Thyroid , 30 :1589 –1600 .
2.
Xing
X
,
Mu
N
,
Yuan
X
,
Wang
N
,
Juhlin
CC
,
Straat
K
,
Larsson
C
,
Xu
D
. 2020 . PLEKHS1 over-expression is associated with metastases and poor outcomes in papillary thyroid carcinoma . Cancers (Basel) , 12 :2133 .
3.
Fredriksson
NJ
,
Ny
L
,
Nilsson
JA
,
Larsson
E
. 2014 . Systematic analysis of noncoding somatic mutations and gene expression alterations across 14 tumor types . Nat Genet , 46 :1258 –1263 .
4.
Rheinbay
E
,
Nielsen
MM
,
Abascal
F
,
Wala
JA
,
Shapira
O
,
Tiao
G
,
Hornshoj
H
,
Hess
JM
,
Juul
RI
,
Lin
Z
,
Feuerbach
L
,
Sabarinathan
R
,
Madsen
T
,
Kim
J
,
Mularoni
L
,
Shuai
S
,
Lanzos
A
,
Herrmann
C
,
Maruvka
YE
,
Shen
C
,
Amin
SB
,
Bandopadhayay
P
,
Bertl
J
,
Boroevich
KA
,
Busanovich
J
,
Carlevaro-Fita
J
,
Chakravarty
D
,
Chan
CWY
,
Craft
D
,
Dhingra
P
,
Diamanti
K
,
Fonseca
NA
,
Gonzalez-Perez
A
,
Guo
Q
,
Hamilton
MP
,
Haradhvala
NJ
,
Hong
C
,
Isaev
K
,
Johnson
TA
,
Juul
M
,
Kahles
A
,
Kahraman
A
,
Kim
Y
,
Komorowski
J
,
Kumar
K
,
Kumar
S
,
Lee
D
,
Lehmann
KV
,
Li
Y
,
Liu
EM
,
Lochovsky
L
,
Park
K
,
Pich
O
,
Roberts
ND
,
Saksena
G
,
Schumacher
SE
,
Sidiropoulos
N
,
Sieverling
L
,
Sinnott-Armstrong
N
,
Stewart
C
,
Tamborero
D
,
Tubio
JMC
,
Umer
HM
,
Uuskula-Reimand
L
,
Wadelius
C
,
Wadi
L
,
Yao
X
,
Zhang
CZ
,
Zhang
J
,
Haber
JE
,
Hobolth
A
,
Imielinski
M
,
Kellis
M
,
Lawrence
MS
,
von Mering
C
,
Nakagawa
H
,
Raphael
BJ
,
Rubin
MA
,
Sander
C
,
Stein
LD
,
Stuart
JM
,
Tsunoda
T
,
Wheeler
DA
,
Johnson
R
,
Reimand
J
,
Gerstein
M
,
Khurana
E
,
Campbell
PJ
,
Lopez-Bigas
N
,
Drivers
P
,
Functional Interpretation Working Group
PC
,
AWG Structural Variation Working
Group
,
Weischenfeldt
J
,
Beroukhim
R
,
Martincorena
I
,
Pedersen
JS
,
Getz
G
,
Consortium
P
. 2020 . Analyses of non-coding somatic drivers in 2,658 cancer whole genomes . Nature , 578 :102 –111 .
5.
Landa
I
,
Pozdeyev
N
,
Korch
C
,
Marlow
LA
,
Smallridge
RC
,
Copland
JA
,
Henderson
YC
,
Lai
SY
,
Clayman
GL
,
Onoda
N
,
Tan
AC
,
Garcia-Rendueles
MER
,
Knauf
JA
,
Haugen
BR
,
Fagin
JA
,
Schweppe
RE
. 2019 . Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies . Clin Cancer Res , 25 :3141 –3151 .
