Abstract

Get full access to this article
View all access options for this article.
References
1.
Antonica
F
,
Kasprzyk
DF
,
Opitz
R
,
Iacovino
M
,
Liao
XH
,
Dumitrescu
AM
,
Refetoff
S
,
Peremans
K
,
Manto
M
,
Kyba
M
,
Costagliola
S
. 2012 . Generation of functional thyroid from embryonic stem cells . Nature , 491 :66 –71 .
2.
Robinson
DR
,
Wu
YM
,
Kalyana-Sundaram
S
,
Cao
X
,
Lonigro
RJ
,
Sung
YS
,
Chen
CL
,
Zhang
L
,
Wang
R
,
Su
F
,
Iyer
MK
,
Roychowdhury
S
,
Siddiqui
J
,
Pienta
KJ
,
Kunju
LP
,
Talpaz
M
,
Mosquera
JM
,
Singer
S
,
Schuetze
SM
,
Antonescu
CR
,
Chinnaiyan
AM
. 2013 . Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing . Nat Genet , 45 :180 –185 .
3.
Lin
JZ
,
Martagon
AJ
,
Hsueh
WA
,
Baxter
JD
,
Gustafsson
JA
,
Webb
P
,
Phillips
KJ
. 2012 . Thyroid hormone receptor agonists reduce serum cholesterol independent of the LDL receptor . Endocrinology , 153 :6136 –6144 .
4.
de Lange
P
,
Cioffi
F
,
Senese
R
,
Moreno
M
,
Lombardi
A
,
Silvestri
E
,
De Matteis
R
,
Lionetti
L
,
Mollica
MP
,
Goglia
F
,
Lanni
A
. 2011 . Nonthyrotoxic prevention of diet-induced insulin resistance by 3,5-diiodo-l -thyronine in rats . Diabetes , 60 :2730 –2739 .
5.
Lopez
M
,
Varela
L
,
Vazquez
MJ
,
Rodriguez-Cuenca
S
,
Gonzalez
CR
,
Velagapudi
VR
,
Morgan
DA
,
Schoenmakers
E
,
Agassandian
K
,
Lage
R
,
Martinez de Morentin
PB
,
Tovar
S
,
Nogueiras
R
,
Carling
D
,
Lelliott
C
,
Gallego
R
,
Oresic
M
,
Chatterjee
K
,
Saha
AK
,
Rahmouni
K
,
Dieguez
C
,
Vidal-Puig
A
. 2010 . Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance . Nat Med , 16 :1001 –1008 .
6.
Sinha
RA
,
You
SH
,
Zhou
J
,
Siddique
MM
,
Bay
BH
,
Zhu
X
,
Privalsky
ML
,
Cheng
SY
,
Stevens
RD
,
Summers
SA
,
Newgard
CB
,
Lazar
MA
,
Yen
PM
. 2012 . Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy . J Clin Invest , 122 :2428 –2438 .
7.
Lopez-Juarez
A
,
Remaud
S
,
Hassani
Z
,
Jolivet
P
,
Pierre Simons
J
,
Sontag
T
,
Yoshikawa
K
,
Price
J
,
Morvan-Dubois
G
,
Demeneix
BA
. 2012 . Thyroid hormone signaling acts as a neurogenic switch by repressing Sox2 in the adult neural stem cell niche . Cell Stem Cell , 10 :531 –543 .
8.
Mittag
J
,
Lyons
DJ
,
Sallstrom
J
,
Vujovic
M
,
Dudazy-Gralla
S
,
Warner
A
,
Wallis
K
,
Alkemade
A
,
Nordstrom
K
,
Monyer
H
,
Broberger
C
,
Arner
A
,
Vennstrom
B
. 2013 . Thyroid hormone is required for hypothalamic neurons regulating cardiovascular functions . J Clin Invest , 123 :509 –516 .
9.
Ng
L
,
Kelley
MW
,
Forrest
D
. 2013 . Making sense with thyroid hormone—the role of T(3) in auditory development . Nat Rev Endocrinol , 9 :296 –307 .
10.
Alexander
EK
,
Kennedy
GC
,
Baloch
ZW
,
Cibas
ES
,
Chudova
D
,
Diggans
J
,
Friedman
L
,
Kloos
RT
,
LiVolsi
VA
,
Mandel
SJ
,
Raab
SS
,
Rosai
J
,
Steward
DL
,
Walsh
PS
,
Wilde
JI
,
Zeiger
MA
,
Lanman
RB
,
Haugen
BR
. 2012 . Preoperative diagnosis of benign thyroid nodules with indeterminate cytology . N Engl J Med , 367 :705 –715 .
11.
Nikiforov
YE
,
Ohori
NP
,
Hodak
SP
,
Carty
SE
,
LeBeau
SO
,
Ferris
RL
,
Yip
L
,
Seethala
RR
,
Tublin
ME
,
Stang
MT
,
Coyne
C
,
Johnson
JT
,
Stewart
AF
,
Nikiforova
MN
. 2011 . Impact of mutational testing on the diagnosis and management of patients with cytologically indeterminate thyroid nodules: a prospective analysis of 1056 FNA samples . J Clin Endocrinol Metab , 96 :3390 –3397 .
12.
Gupta-Abramson
V
,
Troxel
AB
,
Nellore
A
,
Puttaswamy
K
,
Redlinger
M
,
Ransone
K
,
Mandel
SJ
,
Flaherty
KT
,
Loevner
LA
,
O'Dwyer
PJ
,
Brose
MS
. 2008 . Phase II trial of sorafenib in advanced thyroid cancer . J Clin Oncol , 26 :4714 –4719 .
13.
Kurzrock
R
,
Sherman
SI
,
Ball
DW
,
Forastiere
AA
,
Cohen
RB
,
Mehra
R
,
Pfister
DG
,
Cohen
EE
,
Janisch
L
,
Nauling
F
,
Hong
DS
,
Ng
CS
,
Ye
L
,
Gagel
RF
,
Frye
J
,
Muller
T
,
Ratain
MJ
,
Salgia
R
. 2011 . Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer . J Clin Oncol , 29 :2660 –2666 .
14.
Mayerl
S
,
Visser
TJ
,
Darras
VM
,
Horn
S
,
Heuer
H
. 2012 . Impact of Oatp1c1 deficiency on thyroid hormone metabolism and action in the mouse brain . Endocrinology , 153 :1528 –1537 .
15.
Visser
WE
,
Swagemakers
SM
,
Ozgur
Z
,
Schot
R
,
Verheijen
FW
,
van Ijcken
WF
,
van der Spek
PJ
,
Visser
TJ
. 2010 . Transcriptional profiling of fibroblasts from patients with mutations in MCT8 and comparative analysis with the human brain transcriptome . Hum Mol Genet , 19 :4189 –4200 .
16.
Hackenmueller
SA
,
Marchini
M
,
Saba
A
,
Zucchi
R
,
Scanlan
TS
. 2012 . Biosynthesis of 3-iodothyronamine (T1AM) is dependent on the sodium-iodide symporter and thyroperoxidase but does not involve extrathyroidal metabolism of T4 . Endocrinology , 153 :5659 –5667 .
17.
Scanlan
TS
,
Suchland
KL
,
Hart
ME
,
Chiellini
G
,
Huang
Y
,
Kruzich
PJ
,
Frascarelli
S
,
Crossley
DA
,
Bunzow
JR
,
Ronca-Testoni
S
,
Lin
ET
,
Hatton
D
,
Zucchi
R
,
Grandy
DK
. 2004 . 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone . Nat Med , 10 :638 –642 .
