Clinical Studies Targeting Stroke and Ischemic Insults

Bai J , Lyden PD . Revisiting cerebral postischemic reperfusion injury: new insights in understanding reperfusion failure, hemorrhage, and edema. Int J Stroke, 2015; 10:143–152.

Batchelor P , Dietrich WD , Kochanek PM , Lundbye J . Secondary changes after injury and temperature. Ther Hypothermia Temp Manag, 2016; 6:58–62.

Bergman L , Lundbye JB . Acid-base optimization during hypothermia. Best Pract Res Clin Anaesthesiol, 2015; 29:465–470.

Bullock MR , Lundbye JB , Dietrich WD . Intraoperative temperature management. Ther Hypothermia Temp Manag, 2014; 4:67–71.

Chandrasekaran PN , Dezfulian C , Polderman KH . What is the right temperature to cool post-cardiac arrest patients?. Crit Care, 2015; 19:406.

Douglas PS , Cerqueira MD , Berman DS , Chinnaiyan K , Cohen MS , Lundbye JB , Patel RA , Sengupta PP , Soman P , Weissman NJ , Wong TC; ACC Cardiovascular Imaging Council . The future of cardiac imaging: report of a think tank convened by the American College of Cardiology. JACC Cardiovasc Imaging, 2016; 9:1211–1223.

Dumitrascu OM , Lamb J , Lyden PD . Still cooling after all these years: meta-analysis of pre-clinical trials of therapeutic hypothermia for acute ischemic stroke. J Cereb Blood Flow Metab, 2016; 36:1157–1164.

Kuramatsu JB , Kollmar R , Gerner ST , Madžar D , Pisarčíková A , Staykov D , Kloska SP , Doerfler A , Eyüpoglu IY , Schwab S , Huttner HB . Is hypothermia helpful in severe subarachnoid hemorrhage? An exploratory study on macro vascular spasm, delayed cerebral infarction and functional outcome after prolonged hypothermia. Cerebrovasc Dis, 2015; 40:228–235.

Lahiri S , Schlick K , Kavi T , Song S , Moheet A , Yusufali T , Rosengart A , Alexander MJ , Lyden PD . Optimizing outcomes for mechanically ventilated patients in an era of endovascular acute ischemic stroke therapy. J Intensive Care Med, 2016. [Epub ahead of print]; DOI: 10.1177/088506663168.

Lamb JA , Rajput PS , Lyden PD . Novel method for inducing rapid, controllable therapeutic hypothermia in rats using a perivascular implanted closed-loop cooling circuit. J Neurosci Methods, 2016; 267:55–61.

Lundbye JB , Fernandez AB . MI to cool?. Ther Hypothermia Temp Manag, 2015; 5:125.

Lundbye J , Holzer M , Polderman KH . Perspectives on temperature management. Ther Hypothermia Temp Manag, 2015; 5:188–192.

Lyden P , Hemmen T , Grotta J , Rapp K , Ernstrom K , Rzesiewicz T , Parker S , Concha M , Hussain S , Agarwal S , Meyer B , Jurf J , Altafullah I , Raman R; Collaborators : results of the ICTuS 2 Trial (Intravascular Cooling in the Treatment of Stroke 2). Stroke, 2016; 47:2888–2895.

Lyden PD , Hemmen TM , Grotta J , Rapp K , Raman R . Endovascular therapeutic hypothermia for acute ischemic stroke: ICTuS 2/3 protocol. Int J Stroke, 2014; 9:117–125.

Lyden PD , Lopez-de-Sa E , Nichol G , Kiragu AW . Current advances in the use of therapeutic hypothermia. Ther Hypothermia Temp Manag, 2016; 6:2–5.

Polderman KH . Of ions and temperature: the complicated interplay of temperature, fluids, and electrolytes on myocardial function. Crit Care, 2013; 17:1018.

Polderman KH , Noc M , Beishuizen A , Biermann H , Girbes AR , Tully GW , Seidman D , Albertsson PA , Holmberg M , Sterz F , Holzer M . Ultrarapid induction of hypothermia using continuous automated peritoneal lavage with ice-cold fluids final results of the cooling for cardiac arrest or acute ST-elevation myocardial infarction trial. Crit Care Med, 43:2191–2201.

Polderman KH , Noc M , Kurz M , Aibiki M . Therapeutic hypothermia in post-cardiac arrest and myocardial infarction. Ther Hypothermia Temp Manag, 2015; 5:193–197.

Polderman KH , Varon J . How low should we go? Hypothermia or strict normothermia after cardiac arrest?. Circulation, 2015; 131:669–675.

Regensburger M , Huttner HB , Doerfler A , Schwab S , Staykov D . Propofol-related urine discoloration in a patient with fatal atypical intracerebral hemorrhage treated with hypothermia. Springerplus, 2014; 3:551.

Staykov D , Kuramatsu JB , Bardutzky J , Volbers B , Gerner ST , Kloska SP , Doerfler A , Schwab S , Huttner HB . Efficacy and safety of combined intraventricular fibrinolysis with lumbar drainage for prevention of permanent shunt dependency after intracerebral hemorrhage with severe ventricular involvement: a randomized trial and individual patient data meta-analysis. Ann Neurol, 2016. [Epub ahead of print]; DOI: 10.1002/ana24834.

Volbers B , Herrmann S , Willfarth W , Lücking H , Kloska SP , Doerfler A , Huttner HB , Kuramatsu JB , Schwab S , Staykov D . Impact of hypothermia initiation and duration on perihemorrhagic edema evolution after intracerebral hemorrhage. Stroke, 2016; 47:2249–2255.