Nanozymes, as innovative enzyme mimics, hold significant promise for wound care, including antibacterial properties and tissue regeneration. Given their potential to transform wound management, this study utilizes advanced bibliometric tools to provide a comprehensive analysis of the nanozyme research landscape. The analysis covers various aspects, including publication trends, institutional contributions, journal coverage, and author involvement, offering a holistic view of research dynamics. It reveals the evolution of nanozyme research across different phases of wound healing by examining keyword co-occurrence frequencies and timeline developments. In addition, the study identifies emerging research clusters within these phases, focusing on three key areas: enhancing nanozyme performance, integrating them with hydrogel matrices, and developing responsiveness to external stimuli. These clusters highlight the increasing sophistication and diversity of nanozyme-based solutions for wound care. Furthermore, the study explores the intersection of nanozyme research with artificial intelligence (AI) and wearable sensors. This integration presents unprecedented opportunities for real-time monitoring, personalized treatment plans, and predictive analytics in wound care. The findings indicate a growing interest in this interdisciplinary field, pinpointing research frontiers centered around AI-driven wound assessment, continuous monitoring through wearable technologies, and the application of AI algorithms in nanozyme-based wound dressings. In summary, this bibliometric study provides a comprehensive global overview of research trends, key literature, hotspots, and emerging frontiers in nanozyme-based wound care. By investigating the synergy between AI, wearable sensors, and nanozymes, it elucidates the potential for novel and personalized treatment strategies in this rapidly advancing field.
Impact Statement
This study presents the first bibliometric analysis of the impact of nanozymes on wound care over the past 18 years. Unlike traditional literature reviews, this study utilizes quantitative methodologies and tools to analyze information obtained from publications related to nanozyme applications in wound care. This investigation reveals correlations, emerging trends, and the significant impact of research efforts in nanozyme-based wound management.
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References
1.
PowersJG, HighamC, BroussardK, et al.Wound healing and treating wounds: Chronic wound care and management. J Am Acad Dermatol, 2016; 74(4):607–625; doi: 10.1016/j.jaad.2015.08.070
2.
MortonLM, PhillipsTJ. Wound healing and treating wounds: Differential diagnosis and evaluation of chronic wounds. J Am Acad Dermatol, 2016; 74(4):589–605; doi: 10.1016/j.jaad.2015.08.068
WangP-H, HuangB-S, HorngH-C, et al.Wound healing. J Chin Med Assoc, 2018; 81(2):94–101; doi: 10.1016/j.jcma.2017.11.002
5.
MartinP, NunanR. Cellular and molecular mechanisms of repair in acute and chronic wound healing. Br J Dermatol, 2015; 173(2):370–378; doi: 10.1111/bjd.13954
6.
MetcalfeAD, FergusonMWJ. Tissue engineering of replacement skin: The crossroads of biomaterials, wound healing, embryonic development, stem cells and regeneration. J R Soc Interface, 2007; 4(14):413–437; doi: 10.1098/rsif.2006.0179
7.
WilliamsM. Wound infections: An overview. Br J Community Nurs, 2021; 26(Suppl 6):S22–S25; doi: 10.12968/bjcn.2021.26.Sup6.S22
8.
FreedmanBR, HwangC, TalbotS, et al.Breakthrough treatments for accelerated wound healing. Sci Adv, 2023; 9(20):eade7007; doi: 10.1126/sciadv.ade7007
9.
SenCK. Human wound and its burden: Updated 2020 compendium of estimates. Adv Wound Care (New Rochelle), 2021; 10(5):281–292; doi: 10.1089/wound.2021.0026
10.
EgglestonRB. Wound management: Wounds with special challenges. Vet Clin North Am Equine Pract, 2018; 34(3):511–538; doi: 10.1016/j.cveq.2018.07.003
TianH, YanJ, ZhangW, et al.Cu-GA-coordination polymer nanozymes with triple enzymatic activity for wound disinfection and accelerated wound healing. Acta Biomater, 2023; 167:449–462; doi: 10.1016/j.actbio.2023.05.048
13.
CaoC, ZhangT, YangN, et al.POD Nanozyme optimized by charge separation engineering for light/pH activated bacteria catalytic/photodynamic therapy. Signal Transduct Target Ther, 2022; 7(1):86; doi: 10.1038/s41392-022-00900-8
14.
WuS-C, TsaiT-T, LiT-H, et al.Palladium-platinum bimetallic nanomaterials and their application in Staphylococcus aureus detection on paper-based devices. Biosens Bioelectron, 2022; 216:114669; doi: 10.1016/j.bios.2022.114669
15.
ChandikaP, OhG-W, HeoS-Y, et al.Electrospun porous bilayer nano-fibrous fish collagen/PCL bio-composite scaffolds with covalently cross-linked chitooligosaccharides for full-thickness wound-healing applications. Mater Sci Eng C Mater Biol Appl, 2021; 121:111871; doi: 10.1016/j.msec.2021.111871
16.
WuJ, WangX, WangQ, et al.Nanomaterials with enzyme-like characteristics (nanozymes): Next-generation artificial enzymes (II). Chem Soc Rev, 2019; 48(4):1004–1076; doi: 10.1039/c8cs00457a
17.
HuZ, ShanJ, CuiY, et al.Nanozyme‐incorporated microneedles for the treatment of chronic wounds. Adv Healthcare Materials, 2024; 13(20):2400101; doi: 10.1002/adhm.202400101
18.
YangM, WangZ, SuM, et al.Smart nanozymes for diagnosis of bacterial infection: The next frontier from laboratory to bedside testing. ACS Appl Mater Interfaces, 2024; 16(34):44361–44375; doi: 10.1021/acsami.4c07043
19.
WuH, WeiM, HuS, et al.A photomodulable bacteriophage-spike nanozyme enables dually enhanced biofilm penetration and bacterial capture for photothermal-boosted catalytic therapy of MRSA infections. Adv Sci (Weinh), 2023; 10(24):e2301694; doi: 10.1002/advs.202301694
20.
SunN, SunY, XingY, et al.Knowledge mapping and research trends of stem cell in wound healing: A bibliometric analysis. Int Wound J, 2024; 21(2):e14587; doi: 10.1111/iwj.14587
21.
LiuX, YanZ, ZhangY, et al.Two-Dimensional metal-organic framework/enzyme hybrid nanocatalyst as a benign and self-activated cascade reagent for in vivo wound healing. ACS Nano, 2019; 13(5):5222–5230; doi: 10.1021/acsnano.8b09501
22.
XiaoJ, ChenS, YiJ, et al.A cooperative copper metal–organic framework-hydrogel system improves wound healing in diabetes. Adv Funct Mater, 2017; 27(1):1604872; doi: 10.1002/adfm.201604872
23.
WangX, ShiQ, ZhaZ, et al.Copper single-atom catalysts with photothermal performance and enhanced nanozyme activity for bacteria‐infected wound therapy. Bioact Mater, 2021; 6(12):4389–4401; doi: 10.1016/j.bioactmat.2021.04.024
24.
LiY, FuR, DuanZ, et al.Construction of multifunctional hydrogel based on the tannic acid-metal coating decorated MoS2 dual nanozyme for bacteria-infected wound healing. Bioact Mater, 2022; 9:461–474; doi: 10.1016/j.bioactmat.2021.07.023
25.
HuW-C, YounisMR, ZhouY, et al.In situ fabrication of ultrasmall gold nanoparticles/2D MOFs hybrid as nanozyme for antibacterial therapy. Small, 2020; 16(23):e2000553; doi: 10.1002/smll.202000553
26.
ChenC. CiteSpace II: Detecting and visualizing emerging trends and transient patterns in scientific literature. J Am Soc Inf Sci, 2006; 57(3):359–377; doi: 10.1002/asi.20317
27.
YinW, YuJ, LvF, et al.Functionalized nano-MoS2 with peroxidase catalytic and near-infrared photothermal activities for safe and synergetic wound antibacterial applications. ACS Nano, 2016; 10(12):11000–11011; doi: 10.1021/acsnano.6b05810
28.
ShanJ, LiX, YangK, et al.Efficient bacteria killing by Cu2WS4 nanocrystals with enzyme-like properties and bacteria-binding ability. ACS Nano, 2019; 13(12):13797–13808; doi: 10.1021/acsnano.9b03868
29.
YangY, WuX, MaL, et al.Bioinspired spiky peroxidase-mimics for localized bacterial capture and synergistic catalytic sterilization. Adv Mater, 2021; 33(8):e2005477; doi: 10.1002/adma.202005477
30.
MoF, ZhangM, DuanX, et al.Recent advances in nanozymes for bacteria-infected wound therapy. Int J Nanomedicine, 2022; 17:5947–5990; doi: 10.2147/IJN.S382796
31.
GaoL, YanX. Nanozymes: An emerging field bridging nanotechnology and biology. Sci China Life Sci, 2016; 59(4):400–402; doi: 10.1007/s11427-016-5044-3
32.
SinghS, RaiN, TiwariH, et al.Recent advancements in the formulation of nanomaterials-based nanozymes, their catalytic activity, and biomedical applications. ACS Appl Bio Mater, 2023; 6(9):3577–3599; doi: 10.1021/acsabm.3c00253
33.
ShengJ, WuY, DingH, et al.Multienzyme‐Like nanozymes: Regulation, rational design, and application. Adv Mater, 2024; 36(10):e2211210; doi: 10.1002/adma.202211210
34.
JiangP, ZhangL, LiuX, et al.Tuning oxidant and antioxidant activities of ceria by anchoring copper single-site for antibacterial application. Nat Commun, 2024; 15(1):1010; doi: 10.1038/s41467-024-45255-6
YuX, WangL, ZhuZ, et al.Piezoelectric effect modulates nanozyme activity: Underlying mechanism and practical application. Small, 2023; 19(52):e2304818; doi: 10.1002/smll.202304818
49.
ZlobinaK, MalekosE, ChenH, et al.Robust classification of wound healing stages in both mice and humans for acute and burn wounds based on transcriptomic data. BMC Bioinformatics, 2023; 24(1):166; doi: 10.1186/s12859-023-05295-z
GaoF, ShaoT, YuY, et al.Surface-bound reactive oxygen species generating nanozymes for selective antibacterial action. Nat Commun, 2021; 12(1):745; doi: 10.1038/s41467-021-20965-3
54.
KurianAG, SinghRK, SagarV, et al.Nanozyme-Engineered hydrogels for anti-inflammation and skin regeneration. Nanomicro Lett, 2024; 16(1):110; doi: 10.1007/s40820-024-01323-6
55.
XieX, LeiY, LiY, et al.Dual-crosslinked bioadhesive hydrogel as NIR/pH stimulus-responsiveness platform for effectively accelerating wound healing. J Colloid Interface Sci, 2023; 637:20–32; doi: 10.1016/j.jcis.2023.01.081
56.
LiQ, DongM, HanQ, et al.Enhancing diabetic wound healing with a pH-responsive nanozyme hydrogel featuring multi-enzyme-like activities and oxygen self-supply. J Control Release, 2024; 365:905–918; doi: 10.1016/j.jconrel.2023.12.015
57.
WangP, WuJ, XiaoX, et al.Engineering injectable coassembled hydrogel by photothermal driven chitosan-stabilized MoS2 nanosheets for infected wound healing. ACS Nano, 2024; 18(39):26961–26974; doi: 10.1021/acsnano.4c08883
58.
FanC, ZhaoJ, TangY, et al.Using near-Infrared I/II light to regulate the performance of nanozymes. J Anal Test, 2023; 7(3):272–284; doi: 10.1007/s41664-023-00257-z
59.
SunG, JiangX, LiuC, et al.FeS@LAB-35@Ti3C2 as a high-efficiency nanozyme for near infrared light induced photothermal enhanced chemodynamic antibacterial activity and wound healing. Nano Res, 2023; 16(2):2840–2850; doi: 10.1007/s12274-022-4965-3
60.
GaoL-Z, YanX-Y. Discovery and current application of nanozyme. Acta Agron Sin, 2013; 40(10):892; doi: 10.3724/SP.J.1206.2013.00409
61.
ArsalanA, YounusH. Enzymes and nanoparticles: Modulation of enzymatic activity via nanoparticles. Int J Biol Macromol, 2018; 118(Pt B):1833–1847; doi: 10.1016/j.ijbiomac.2018.07.030
62.
HuFX, HuG, WangDP, et al.Integrated biochip-electronic system with single-atom nanozyme for in vivo analysis of nitric oxide. ACS Nano, 2023; 17(9):8575–8585; doi: 10.1021/acsnano.3c00935
63.
JinX, ShanJ, ZhaoJ, et al.Bimetallic oxide Cu–Fe3O4 nanoclusters with multiple enzymatic activities for wound infection treatment and wound healing. Acta Biomater, 2023; 173:403–419; doi: 10.1016/j.actbio.2023.10.028
WuB, YangJ, ZuY, et al.Aligned electrospun fiber film loaded with multi-enzyme mimetic iridium nanozymes for wound healing. J Nanobiotechnology, 2022; 20(1):478; doi: 10.1186/s12951-022-01685-2
66.
LiF, MaoZ, DuY, et al.Mesoporous MOFs with ROS scavenging capacity for the alleviation of inflammation through inhibiting stimulator of interferon genes to promote diabetic wound healing. J Nanobiotechnology, 2024; 22(1):246; doi: 10.1186/s12951-024-02423-6
67.
GaoY, ZhuZ, ChenZ, et al.Machine learning in nanozymes: From design to application. Biomater Sci, 2024; 12(9):2229–2243; doi: 10.1039/d4bm00169a
68.
YuR, WangR, WangZ, et al.Applications of DNA-nanozyme-based sensors. Analyst, 2021; 146(4):1127–1141; doi: 10.1039/d0an02368j
69.
YuZ, GongH, LiM, et al.Hollow prussian blue nanozyme-richened liposome for artificial neural network-assisted multimodal colorimetric-photothermal immunoassay on smartphone. Biosens Bioelectron, 2022; 218:114751; doi: 10.1016/j.bios.2022.114751
70.
HuS, YangC, LiY, et al.Nanozyme sensor array based on manganese dioxide for the distinction between multiple amyloid β peptides and their dynamic aggregation process. Biosens Bioelectron, 2022; 199:113881; doi: 10.1016/j.bios.2021.113881
71.
LiuM-X, ZhangH, ZhangX-W, et al.Nanozyme sensor array plus solvent-mediated signal amplification strategy for ultrasensitive ratiometric fluorescence detection of exosomal proteins and cancer identification. Anal Chem, 2021; 93(25):9002–9010; doi: 10.1021/acs.analchem.1c02010
72.
ŞenM, YüzerE, DoğanV, et al.Colorimetric detection of H2O2 with Fe3O4@chi nanozyme modified µPADs using artificial intelligence. Mikrochim Acta, 2022; 189(10):373; doi: 10.1007/s00604-022-05474-4
73.
NiuJ, SunS, LiuP, et al.Copper-based nanozymes: Properties and applications in biomedicine. J Inorganic Mater, 2023; 38(5):489; doi: 10.15541/jim20220716
