Novel blends of poly(L-lactic acid) (PLLA) and a water-soluble amphiphilic poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate) (PMB30W) were prepared as materials for temporary scaffolding to provide mechanical support to the vessel wall until adequate vascular healing is achieved, after which the scaffold disappears. The PLLA/PMB30W cast films demonstrated higher breaking strengths than PLLA cast films, and their Young's modulus was similar to that of PLLA under dry conditions. A high density of phosphorylcholine head groups on the inner surface of PLLA/PMB30W tubing was developed by repeated coatings with the PLLA/PMB30W blend polymer solutions. The PLLA/PMB30W tubing showed stable degradation behaviors similar to those of the PLLA tubing. This is the first report that demonstrates cell membrane–like materials that can be used in temporary scaffolding of the vessel wall; these materials are characterized by strong mechanical properties and stable degradation behaviors that are superior or similar to those of high-molecular-weight PLLA.
Get full access to this article
View all access options for this article.
References
1.
MauriL., HsiehW., MassaroJ.M., HoK.K.L., D'AgostinoR., CutlipD.E.Stent thrombosis in randomized clinical trials of drug-eluting stents. N Engl J Med, 356:1020. 2007.
2.
DaemenJ., WenaweserP., TsuchidaK., AbrechtL., VainaS., MorgerC., KukrejaN., JüniP., SianosP., HelligeG., van DomburgR.T., HessO.M., BoersmaE., MeierB., WindeckerS., SerruysP.W.Early and late coronary stent thrombosis of sirolimus-eluting and paclitaxel-eluting stents in routine clinical practice: data from a large two-institutional cohort study. Lancet, 369:667. 2007.
3.
OrmistonJ.A., SerruysP.W., RegarE., DudekD., ThuesenL., WebsterM.W., OnumaY., Garcia-GarciaH.M., McGreevyR., VeldhofS.A bioabsorbable everolimus-eluting coronary stent system for patients with single de-novo coronary artery lesions (ABSORB): a prospective open-label trial. Lancet, 371:899. 2008.
4.
BüngerC.M., GrabowN., SternbergK., KrögerC., KetnerL., SchmitzK., KreutzerH.J., InceH., NienaberC.A., KlarE., SchareckW.Sirolimus-eluting biodegradable poly-L-lactide stent for peripheral vascular application: a preliminary study in porcine carotid arteries. J Surg Res, 139:77. 2007.
5.
IgnatiusA.A., ClaesL.E.In vitro biocompatibility of bioresorbable polymers: poly(L,DL-lactide) and poly(L-lactide-co-glycolide)Biomaterials, 17:831. 1996.
6.
TamaiH., IgakiK., KyoE., KosugaK., KawashimaA., MatsuiS., KomoriH., TsujiT., MotoharaS., UehataH.Initial and 6-month results of biodegradable poly-L-lactic acid coronary stents in humans. Circulation, 102:399. 2000.
7.
BergsmaJ.E., de BruijnW.C., RozemaF.R., BosR.R.M., BoeringG.Late degradation tissue response to poly(L-lactide) bone plates and screws. Biomaterials, 16:25. 1995.
8.
van der GiessenW.J., LincoffA.M., SchwartzR.S., van BeusekomH.M.M., SerruysP.W., HolmesD.R., EllisS.G., TopolE.J.Marked inflammatory sequelae to implantation of biodegradable and nonbiodegradable polymers in porcine coronary arteries. Circulation, 94:1690. 1996.
IshiharaK., UedaT., NakabayashiN.Preparation of phospholipid polymers and their properties as polymer hydrogel membranes. Polym J, 22:355. 1990.
11.
IshiharaK., TanakaS., FurukawaN., KuritaK., NakabayashiN.Improved blood compatibility of segmented polyurethane by polymeric additives having phospholipid polar groups. 1. Molecular design of polymeric additives and their functions. J Biomed Mater Res, 32:391. 1996.
12.
IshiharaK., ShibataN., TanakaS., IwasakiY., KurosakiT., NakabayashiN.Improved blood compatibility of segmented polyurethane by polymeric additives having phospholipid polar group. 2. Dispersion state of the polymeric additive and protein adsorption on the surface. J Biomed Mater Res, 32:401. 1996.
13.
YoneyamaT., IshiharaK., NakabayashiN., ItoM., MishimaY.Short-term in vivo evaluation of small-diameter vascular prosthesis composed of segmented poly(etherurethane)/2-methacryloyloxyethyl phosphorylcholine polymer blend. J Biomed Mater Res, 43:15. 1998.
14.
SnyderT.A., TsukuiH., KiharaS., AkimotoT., LitwakK.N., KamenevaM.V., YamazakiK., WagnerW.R.Preclinical biocompatibility assessment of the EVAHEART ventricular assist device: coating comparison and platelet activation. J Biomed Mater Res A, 81:85. 2007.
15.
HasegawaT., IwasakiY., IshiharaK.Preparation of blood-compatible hollow fibers from a polymer alloy composed of polysulfone and 2-methacryloyloxyethyl phosphorylcholine polymer. J Biomed Mater Res B, 63:333. 2002.
16.
YeS.H., WatanabeJ., IwasakiY., IshiharaK.Antifouling blood purification membrane composed of cellulose acetate and phospholipid polymer. Biomaterials, 24:4143. 2003.
17.
LewisA.L., TolhurstL.A., StratfordP.W.Analysis of a phosphorylcholine-based polymer coating on a coronary stent pre- and post-implantation. Biomaterials, 23:1697. 2002.
18.
HunterS., AngeliniG.D.Phosphatidylcholine-coated chest tubes improve drainage after open heart operation. Ann Thorac Surg, 56:1339. 1993.
19.
IshiharaK., NomuraH., MiharaT., KuritaK., IwasakiY., NakabayashiN.Why do phospholipid polymers reduce protein adsorption?J Biomed Mater Res, 39:323. 1998.
20.
IshiharaK., OshidaH., EndoY., UedaT., WatanabeA., NakabayashiN.Hemocompatibility of human whole blood on polymers with a phospholipid polar group and its mechanism. J Biomed Mater Res, 26:1543. 1992.
21.
CharltonD.C., PetersonM.G.E., SpillerK., LowmanA., TorzilliP.A., MaherS.A.Semi-degradable scaffold for articular cartilage replacement. Tissue Eng A, 14:207. 2008.
22.
YoonS.J., KimS.H., HaH.J., KoY.K., SoJ.W., KimM.S., YangY.I. Khang, G, RheeJ.M., LeeH.B.Reduction of inflammatory reaction of poly(D,L-lactic-co-glycolic acid) using demineralized bone particles. Tissue Eng A, 14:539. 2008.
23.
KhangG., ChoiM.K., RheeJ.M., LeeS.J., LeeH.B., IwasakiY., NakabayashiN., IshiharaK.Biocompatibility of poly(MPC-co-EHMA)/poly(L-lactide-co-glycolide) blends. Korea Polym J, 9:107. 2001.
24.
IwasakiY., SawadaS., IshiharaK., KhangG., LeeH.B.Reduction of surface-induced inflammatory reaction on PLGA/MPC polymer blend. Biomaterials, 23:3897. 2002.
25.
DiabC., TribetC., GohonY., PopotJ.L., WinnikF.M.Complexation of integral membrane proteins by phosphorylcholine-based amphipols. Biochim Biophys Acta, 1768:2737. 2007.
26.
KonnoT., KuritaK., IwasakiY., NakabayashiN., IshiharaK.Preparation of nanoparticles composed with bioinspired 2-methacryloyloxyethyl phosphorylcholine polymer. Biomaterials, 22:1883. 2001.
27.
ChenC., ChuehJ., TsengH., HuangH., LeeS.Preparation and characterization of biodegradable PLA polymeric blends. Biomaterials, 24:1167. 2003.
28.
IshiharaK., AragakiR., UedaT., WatenabeA., NakabayashiN.Reduced thrombogenicity of polymers having phospholipid polar groups. J Biomed Mater Res, 24:1069. 1990.
29.
TherinM., ChristelP., LiS., GarreauH., VertM.In vivo degradation of massive poly(α-hydroxy acids): validation of in vitro findings. Biomaterials, 13:594. 1992.
30.
SchmitzJ.P., ZardenetaG., AgrawalC.M., LeeT., AthanasiouK., MilamS.B.Protein interactions with polylactide-polyglycolide particles and scaffolds. Tissue Eng, 3:257. 1997.
31.
MarioC.D., FerranteG.Biodegradable drug-eluting stents: promises and pitfalls. Lancet, 371:873. 2008.
32.
SlottowT.L.P., WaksmanR.Overview of the 2007 food and drug administration circulatory system devices panel meeting on the endeavor Zotarolimus-eluting coronary stent. Circulation, 117:1603. 2008.
Supplementary Material
Please find the following supplemental material available below.
For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.
For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.
