Epicatechin (EC)-based derivatives have garnered significant attention for their powerful antioxidant, anti-inflammatory, anticancer, and antibacterial properties, all of which are attributed to the phenolic hydroxyl groups in their structure. These compounds are promising in regenerative medicine, particularly as bioactive components in scaffolds. This review provides an in-depth analysis of the mechanisms by which EC-based materials enhance tissue repair, examining their application in various scaffold forms, such as hydrogels, nanoparticles, and nanofibers. This study also addresses the challenges of stability and bioavailability associated with ECs and proposes encapsulation techniques to overcome these barriers. The potential clinical benefits of ECs in regenerative medicine and their role in fostering advancements in tissue engineering are discussed, making this review a valuable resource for guiding future studies on the integration of ECs into clinical practice.
Impact Statement
This comprehensive review underscores the transformative potential of EC-based derivatives in advancing tissue engineering. By examining the antioxidant, anti-inflammatory, antibacterial, and anticancer properties of ECs, we highlight their promising application in bioactive scaffolds to support tissue repair and regeneration. Key challenges such as stability and bioavailability are addressed, along with innovative encapsulation and scaffold integration strategies that increase EC efficacy. These findings can guide future research and clinical applications, positioning ECs as vital components in the development of next-generation therapeutic scaffolds for regenerative medicine and precision health care.
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