Tissue engineering has shown a great promise as a solution to the high demand for tissue and organ transplantations. Biomaterial scaffolds serve to house and direct cells to grow, exposing them to an adequate perfusion of nutrients, oxygen, metabolic products, and appropriate growth factors to enhance their differentiation and function. The degradation of biomaterial scaffolds is a key factor to successful tissue regeneration. In this article, the existing degradation control approaches in the context of scaffold tissue engineering were reviewed and a new paradigm of thinking called active control of scaffold degradation, proposed elsewhere by us, was also revisited and discussed in light of its benefit and requirement of this new technology.
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