MukherjeeV, EvansL. Implementation of the Surviving Sepsis Campaign guidelines. Curr Opin Crit Care, 2017; 23:412–416.
5.
PepperDJ, SunJ, CuiX, et al.Antibiotic- and fluid-focused bundles potentially improve sepsis management, but high-quality evidence is lacking for the specificity required in the Centers for Medicare and Medicaid Service's sepsis bundle (SEP-1). Crit Care Med, 2019; 47:1290–1300.
WangJ, StrichJR, ApplefeldWN, et al.Driving blind: Instituting SEP-1 without high quality outcomes data. J Thorac Dis, 2020; 12(Suppl 1):S22–S36.
8.
DellingerRP, CarletJM, MasurH, et al.Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med, 2004; 32:858–873.
9.
RhodesA, EvansLE, AlhazzaniW, et al.Surviving Sepsis Campaign: International guidelines for management of sepsis and septic shock: 2016. Crit Care Med, 2017; 45:486–552.
10.
RheeC, ChiotosK, CosgroveSE, et al.Infectious Diseases Society of America Position Paper: Recommended Revisions to the National Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Sepsis Quality Measure. Clin Infect Dis, 2020 (in press).
11.
RheeC, StrichJR, KlompasM, et al.SEP-1 has brought much needed attention to improving sepsis care…but now is the time to improve SEP-1. Crit Care Med, 2020; 48:779–782.
12.
PrescottHC, IwashynaTJ. Improving sepsis treatment by embracing diagnostic uncertainty. Ann Am Thorac Soc, 2019; 16:426–429.
13.
ShahSJ, BarishPN, PrasadPA, et al.Clinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: Comparison of patients with and without COVID-19. medRxiv. 2020.
14.
NicksBA, MantheyDE, FitchMT. The Centers for Medicare and Medicaid Services (CMS) community-acquired pneumonia core measures lead to unnecessary antibiotic administration by emergency physicians. Acad Emerg Med, 2009; 16:184–187.
15.
BuettiN, MazzuchelliT, PrioreEL, et al.Early administered antibiotics do not impact mortality in critically ill patients with COVID-19. J Infect (in press).
16.
HantoushzadehS, NorooznezhadAH. Possible cause of inflammatory storm and septic shock in patients diagnosed with (COVID-19). Arch Med Res, 2020; 51:347–348.
17.
LoftusTJ, BrakenridgeSC, MooreFA, et al.Intubated trauma patients receiving prolonged antibiotics for pneumonia despite negative cultures: Predictors and outcomes. Surg Infect, 2016; 17:766–772.
18.
BariePS, HydoLJ, ShouJ, et al.Influence of antibiotic therapy on mortality of critical surgical illness caused or complicated by infection. Surg Infect, 2005; 6:41–54.
19.
KumarA, RobertsD, WoodKE, et al.Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med, 2006; 34:1589–1596.
20.
BarochiaAV, CuiX, VitbergD, et al.Bundled care for septic shock: An analysis of clinical trials. Crit Care Med, 2010; 38:668–678.
21.
GaieskiDF, MikkelsenME, BandRA, et al.Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department. Crit Care Med, 2010; 38:1045–1053.
22.
FerrerR, Martin-LoechesI, PhillipsG, et al.Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program. Crit Care Med, 2014; 42:1749–1755.
23.
SeymourCW, GestenF, PrescottHC, et al.Time to treatment and mortality during mandated emergency care for sepsis. N Engl J Med, 2017; 376:2235–2244.
24.
SeymourCW, GestenF, PrescottHC, et al.Time to treatment and mortality during mandated emergency care for sepsis (Supplemental Appendix). N Engl J Med. 2017; 376:2235–2244.
25.
LevyMM, RhodesA, PhillipsGS, et al.Surviving Sepsis Campaign: Association between performance metrics and outcomes in a 7.5-year study. Crit Care Med, 2015; 43:3–12.
26.
BloosF, Thomas-RuddelD, RuddelH, et al.Impact of compliance with infection management guidelines on outcome in patients with severe sepsis: A prospective observational multi-center study. Crit Care, 2014; 18:R42.
27.
AbeT, OguraH, ShiraishiA, et al.Characteristics, management, and in-hospital mortality among patients with severe sepsis in intensive care units in Japan: The FORECAST study. Crit Care, 2018; 22:322.
28.
de GrootB, AnsemsA, GerlingDH, et al.The association between time to antibiotics and relevant clinical outcomes in emergency department patients with various stages of sepsis: A prospective multi-center study. Crit Care, 2015; 19:194.
29.
KaaschAJ, RiegS, KuetscherJ, et al.Delay in the administration of appropriate antimicrobial therapy in Staphylococcus aureus bloodstream infection: A prospective multicenter hospital-based cohort study. Infection, 2013; 41:979–985.
30.
van ZantenAR, BrinkmanS, ArbousMS, et al.Guideline bundles adherence and mortality in severe sepsis and septic shock. Crit Care Med, 2014; 42:1890–1898.
31.
KimH, ChungSP, ChoiSH, et al.Impact of timing to source control in patients with septic shock: A prospective multi-center observational study. J Crit Care, 2019; 53:176-182.
32.
PuskarichMA, TrzeciakS, ShapiroNI, et al.Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol. Crit Care Med, 2011; 39:2066–2071.
33.
HranjecT, RosenbergerLH, SwensonB, et al.Aggressive versus conservative initiation of antimicrobial treatment in critically ill surgical patients with suspected intensive-care-unit-acquired infection: A quasi-experimental, before and after observational cohort study. Lancet Infect Dis, 2012; 12:774-780.
34.
SterlingSA, MillerWR, PryorJ, et al.The impact of timing of antibiotics on outcomes in severe sepsis and septic shock: A systematic review and meta-analysis. Crit Care Med, 2015; 43:1907-1915.
35.
HouckPM, BratzlerDW, NsaW, et al.Timing of antibiotic administration and outcomes for Medicare patients hospitalized with community-acquired pneumonia. Arch Intern Med, 2004; 164:637–644.
36.
FilbinMR, LynchJ, GillinghamTD, et al.Presenting symptoms independently predict mortality in septic Shock: Importance of a previously unmeasured confounder. Crit Care Med, 2018; 46:1592–1599.
37.
KushimotoS, AbeT, OguraH, et al.Impact of body temperature abnormalities on the implementation of sepsis bundles and outcomes in patients with severe sepsis: A retrospective sub-analysis of the focused outcome research on emergency care for acute respiratory distress syndrome, sepsis and trauma study. Crit Care Med, 2019; 47:691–699.
38.
BlotSI, RodriguezA, Sole-ViolanJ, et al.Effects of delayed oxygenation assessment on time to antibiotic delivery and mortality in patients with severe community-acquired pneumonia. Crit Care Med, 2007; 35:2509–2514.
39.
AlamN, OskamE, StassenPM, et al.Prehospital antibiotics in the ambulance for sepsis: A multicentre, open label, randomised trial. Lancet Respir Med, 2018; 6:40-50.
40.
Klein KlouwenbergPM, CremerOL, van VughtLA, et al.Likelihood of infection in patients with presumed sepsis at the time of intensive care unit admission: A cohort study. Crit Care, 2015; 19:319.
41.
FierensJ, DepuydtPO, De WaeleJJ. A practical approach to clinical antibiotic stewardship in the ICU patient with severe infection. Semin Respir Crit Care Med, 2019; 40:435–446.
42.
CampionM, ScullyG. Antibiotic use in the intensive care unit: Optimization and de-escalation. J Intensive Care Med, 2018; 33:647–655.
43.
Del PozoJL. Stewardship in sepsis. Rev Esp Quimioter, 2019; 32(Suppl 2):42–46.
44.
Byoung SooK, Sang HoC, YounsuckK, et al.Safety of antimicrobial de-escalation for culture-negative severe pneumonia. J Crit Care, 2019; 54:14–19.
45.
DeshpandeA, RichterSS, HaesslerS, et al.De-escalation of empiric antibiotics following negative cultures in hospitalized patients with pneumonia: Rates and outcomes. Clin Infect Dis (in press).
46.
ThomasZ, BandaliF, SankaranarayananJ, et al.A multicenter evaluation of prolonged empiric antibiotic therapy in adult ICUs in the United States. Crit Care Med, 2015; 43:2527–2534.