Renewed Interest in Acute Appendicitis: Are Antibiotics Non-Inferior to Surgery or Possibly Clinically Superior? What Is Long-Term Follow-Up and Natural Evolution of Appendicitis Treated Conservatively with “Antibiotics First”?
Restricted accessResearch articleFirst published online June, 2016
Renewed Interest in Acute Appendicitis: Are Antibiotics Non-Inferior to Surgery or Possibly Clinically Superior? What Is Long-Term Follow-Up and Natural Evolution of Appendicitis Treated Conservatively with “Antibiotics First”?
BhanguA, SøreideK, Di SaverioS, et al.Acute appendicitis: Modern understanding of pathogenesis, diagnosis, and management. Lancet, 2015; 386:1278–1287.
2.
FlumDR. Clinical practice. Acute appendicitis—Appendectomy or the “antibiotics first” strategy. N Engl J Med, 2015; 372:1937–1943.
3.
Di SaverioS, SibilioA, GiorginiE, et al.The NOTA Study (Non Operative Treatment for Acute Appendicitis): Prospective study on the efficacy and safety of antibiotics (amoxicillin and clavulanic acid) for treating patients with right lower quadrant abdominal pain and long-term follow-up of conservatively treated suspected appendicitis. Ann Surg, 2014; 260:109–117.
4.
SalminenP, PaajanenH, RautioT, et al.Antibiotic therapy vs appendectomy for treatment of uncomplicated acute appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015; 313:2340–2348.
MasonRJ, MoazzezA, SohnH, KatkhoudaN. Meta-analysis of randomized trials comparing antibiotic therapy with appendectomy for acute uncomplicated (no abscess or phlegmon) appendicitis. Surg Infect, 2012; 13:74–84.
7.
AnderssonR. Antibiotics versus surgery for appendicitis: Comment on Amoxicillin plus clavulanic acid versus appendicectomy for treatment of acute uncomplicated appendicitis: An open-label, non-inferiority, randomised controlled trial. Lancet, 2011; 378:1067.
8.
WebbEM, WangZJ, CoakleyFV, et al.The equivocal appendix at CT: Prevalence in a control population. Emerg Radiol, 2010; 17:57–61.