Gastrointestinal mucormycosis is associated with high mortality rates. Appropriate and early antifungal therapy and prompt surgical intervention are essential.
Method:
Case report and literature review.
Results:
Nineteen case reports were reviewed describing adults with hematologic malignant tumors who developed intestinal mucormycosis and underwent surgery. The overall survival rate was 50%.
Conclusion:
Intestinal mucormycosis is an infection associated with a high mortality rate although adults with underlying hematologic malignant have improved outcomes compared with other groups.
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References
1.
PetrikkosG, SkiadaA, LortholaryO, et al.Epidemiology and clinical manifestations of mucormycosis. Clin Infect Dis, 2012; 54(1_suppl):S23–S34.
2.
PrabhuRM, PatelR. Mucormycosis and entopthoramycosis: A review of the clinical manifestations, diagnosis and treatment. Clin Microbiol Infect, 2004; 10(1_suppl):31–47.
3.
RodenMM, ZaoutisTE, BuchananWL, et al.Epidemiology and outcome of zygomycosis: A review of 929 reported cases. Clin Infect Dis, 2005; 41:634–53.
4.
SpellbergB, WalshTJ, KontoyiannisDP, et al.Recent advances in the management of mucormycosis: From bench to bedside. Clin Infect Dis, 2009; 48:1743–1751.
5.
SkiadaA, LanternierF, GrollAH, et al.Diagnosis and treatment of mucormycosis in patients with hematological malignancies: guidelines from the 3rd European Conference on Infections in Leukemia. Haematologica, 2013; 98:492–504.
6.
KontoyiannisDP, WesselVC, BodeyGP, RolstonKV. Mucormycosis in the 1990s in a tertiary-care cancer center. Clin Infect Dis, 2000; 30:851–856.
7.
AghaFP, LeeHH, BolandCR, et al.Mucormycosis of the colon: Early diagnosis and successful management. AJR Am J Roentgenol, 1985; 145:739–744.
8.
ParraR, ArnauE, JuliaA, et al.Survival after intestinal mucormycosis in acute myelogenous leukemia. Cancer, 1986; 58:2717–2719.
9.
FaberE, RiegrovaD, JarsovaM, et al.Abdominal zygomatic thromboangiitis in a patient with AML and t(1;13;14). Ann Hematol, 1996; 75:195–198.
LeeJH, HaHK, YooE, et al.CT and sonographically guided biopsy in a patient with intestinal mucormycosis. 2000; 175:129–131.
12.
MirN, EdmonsonR, YeghenT, RashidH. Gastrointestinal mucormycosis complicated by arterio-enteric fistula in a patient with with non-Hodgkin's lymphoma. Clin Lab Haem, 200041–43.
13.
SuhW, ParkCS, LeeMSet al.Hepatic and small bowel mucormycosis after chemotherapy in a patient with acute lymphocytic leukemia. J Korean Med Sci, 2000; 15:351–354.
14.
KaranthM, TaniereP, BarracloughJ, et al.A rare presentation of zygomycosis (mucormycosis) and review of the literature. J Clin Pathol, 2005; 58:879–881.
15.
HorgerM, HebartH, SchimmelHet al.Disseminated mucormycosis in haematological patients: CT and MRI findings with pathological correlation. Br J Radiol, 2006; 79:88–95.
16.
SongKY, WonKK, ChongWP, et al.Mucormycosis resulting in gastric perforation in a patient with acute myelogenous leukemia: Report of a case. Surg Today, 2006; 36:831–834.
17.
MadrigalB, ArenalJJ, TorresA, et al.Jejunal mucormycosis in a patient with Hodgkin's lymphoma. Rev Esp Enferm Dig, 2008; 100:507–510.
18.
ChengVCC, ChanJFW, NganAHY, et al.Outbreak of intestinal infection due to Rhizopus microspores. J Clin Micro, 2009; 47:2834–43.
19.
De YaoJT, Al-AmeriA, Garcia-ManeroG, et al.Infrequent presentations of mucormycosis in patients with myelodysplastic syndrome and acute leukemia: Case series and review of the literature. Clin Lymphoma, Myeloma Leuk, 2011; 11:446–451.
20.
LacarriereE, LacazeL, SchwarzLet al.First case of gastrointestinal mucormycosis in an immunocompromised patient with gallbladder and duodenum involvement. Infection, 2011; 39:595–598.
21.
LoOSH and LawWL. Ileocolonic mucormycosis in adult immunocompromised patients: a surgeon's perspective. World J Gastroenterol, 2010; 16:1165–1170.
AlmyroudisNG, SuttonDA, LindenP, et al.Zygomycosis in solid organ transplant recipients in a tertiary transplant center and review of the literature. Am J Transplant, 2006; 6:2365–2374.
27.
Ben-AmiR, LewisRE, TarrandJ, et al.Antifungal activity of colistin against mucorales species in vitro and a murine model of Rhizopus oryzae pulmonary infection. Antimicrob Agents Chemother, 2010; 54:484–490.
28.
KimHJ, RhaSE, KangWK. A patient with neutropenic fever and abdominal pain showing absent bowel wall on CT. Br J Radiol, 2011; 84:478–480.
29.
LeeJH, HaHK, YooE, et al.CT and sonographically guided biopsy in a patient with intestinal mucormycosis. AJR Am J Roentgenol, 2000; 175:129–131.
30.
Lass-FlorlC, ReschG, NachbaurD, et al.The value of computed tomography-guided percutaneous lung biopsy for diagnosis of invasive fungal infection in immunocompromised patients. Clin Infect Dis, 2007; 45:101–104.
