Koblan LW, JL Doman, C Wilson, JM Levy, T Tay, GA Newby, JP Maianti, A Raguram and DR Liu. (2018). Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction. Nat Biotechnol, 36:843–846.
2.
Komor AC, KT Zhao, MS Packer, NM Gaudelli, AL Waterbury, LW Koblan, YB Kim, AH Badran and DR Liu. (2017). Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity. Sci Adv, 3:eaao4774.
3.
Gaudelli NM, AC Komor, HA Rees, MS Packer, AH Badran, DI Bryson and DR Liu. (2017). Programmable base editing of A*T to G*C in genomic DNA without DNA cleavage. Nature, 551:464–471.
4.
Chadwick AC, X Wang and K Musunuru. (2017). In vivo base editing of PCSK9 (proprotein convertase subtilisin/kexin type 9) as a therapeutic alternative to genome editing. Arterioscler Thromb Vasc Biol, 37:1741–1747.
5.
Ryu SM, T Koo, K Kim, K Lim, G Baek, ST Kim, HS Kim, DE Kim, H Lee, E Chung and JS Kim. (2018). Adenine base editing in mouse embryos and an adult mouse model of Duchenne muscular dystrophy. Nat Biotechnol, 36:536–539.
6.
Yeh WH, H Chiang, HA Rees, ASB Edge and DR Liu. (2018). In vivo base editing of post-mitotic sensory cells. Nat Commun, 9:2184.
7.
Zafra MP, EM Schatoff, A Katti, M Foronda, M Breinig, AY Schweitzer, A Simon, T Han, S Goswami, et al. (2018). Optimized base editors enable efficient editing in cells, organoids and mice. Nat Biotechnol, 36:888–893.
8.
Zeng Y, J Li, G Li, S Huang, W Yu, Y Zhang, D Chen, J Chen, J Liu and X Huang. (2018). Correction of the Marfan syndrome pathogenic FBN1 mutation by base editing in human cells and heterozygous embryos. Mol Ther, 26:2631–2637.
9.
Liang P, C Ding, H Sun, X Xie, Y Xu, X Zhang, Y Sun, Y Xiong, W Ma, et al. (2017). Correction of beta-thalassemia mutant by base editor in human embryos. Protein Cell, 8:811–822.
10.
Zhang Y, W Qin, X Lu, J Xu, H Huang, H Bai, S Li and S Lin. (2017). Programmable base editing of zebrafish genome using a modified CRISPR-Cas9 system. Nat Commun, 8:118.
11.
Kosicki M, K Tomberg and A Bradley. (2018). Repair of double-strand breaks induced by CRISPR-Cas9 leads to large deletions and complex rearrangements. Nat Biotechnol, 36:765–771.
12.
Ghezraoui H, M Piganeau, B Renouf, JB Renaud, A Sallmyr, B Ruis, S Oh, AE Tomkinson, EA Hendrickson, et al. (2014). Chromosomal translocations in human cells are generated by canonical nonhomologous end-joining. Mol Cell, 55:829–842.
13.
Boroviak K, B Fu, F Yang, B Doe and A Bradley. (2017). Revealing hidden complexities of genomic rearrangements generated with Cas9. Sci Rep, 7:12867.
14.
Haapaniemi E, S Botla, J Persson, B Schmierer and J Taipale. (2018). CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response. Nat Med, 24:927–930.