Noninvasive ventilation is a standard therapy to treat respiratory distress in children and its successful use has been shown to shorten stay. However, with its application there are risks for adverse events, and therapy failure has been linked to prolonged time on invasive mechanical ventilation, increased stay, and mortality. It is essential for respiratory therapists to understand the factors contributing to noninvasive ventilation failure and what is known on how to predict which children will fail noninvasive ventilation from the existing literature.
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References
1.
AlibrahimO, RehderKJ, MillerAG, RottaAT. Mechanical ventilation and respiratory support in the pediatric intensive care unit. Pediatr Clin North Am, 2022; 69(3):587–605; doi: 10.1016/j.pcl.2022.02.004
2.
KhemaniRG, SmithL, Lopez-FernandezYM, et al.;on behalf of the Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology (PARDIE) Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Paediatric acute respiratory distress syndrome incidence and epidemiology (PARIDE): an international, observational study. Lancet Respir Med, 2019; 7(2):115–128; doi: 10.1016/S2213-2600(18)30344-8
3.
Mayordomo-ColungaJ, Pons-ÒdenaM, MedinaA, et al.Non-invasive ventilation practices in children across Europe. Pediatr Pulmonol, 2018; 53(8):1107–1114; doi: 10.1002/ppul.23988
4.
WolflerA, CalderiniE, IannellaE, et al.;Network of Pediatric Intensive Care Unit Study Group. Evolution of noninvasive mechanical ventilation use: a cohort study among Italian PICUs. Pediatr Crit Care Med, 2015; 16(5):418–427; doi: 10.1097/PCC.0000000000000387
5.
BoghiD, KimKW, KimJH, et al.Noninvasive ventilation for acute respiratory failure in pediatric patients: a systematic review and meta-analysis. Pediatr Crit Care Med, 2023; 24(2):123–132; doi: 10.1097/PCC.0000000000003109
Dohna-SchwakeC, StehlingF, TschiedelE, WallotM, MelliesU. Non-invasive ventilation on a pediatric intensive care unit: feasibility, efficacy, and predictors of success. Pediatr Pulmonol, 2011; 46(11):1114–1120; doi: 10.1002/ppul.21482
8.
EmeriaudG, Pons-ÒdenaM, BhallaAK, et al.;for the Pediatric Acute Respiratory Distress Incidence and Epidemiology (PARDIE) Investigators and Pediatric Acute Lund Injury and Sepsis Investigators (PALISI) Network. Noninvasive ventilation for pediatric acute respiratory distress syndrome: experience from the 2016/2017 pediatric acute respiratory distress syndrome incidence and epidemiology prospective cohort study. Pediatr Crit Care Med, 2023; 24(9):715–726; doi: 10.1097/PCC.0000000000003281
SantschiM, JouvetP, LeclercF, et al.;for the PALIVE Investigators, The Pediatric Acute Lung Injury and Sepsis Investigators Network (PALISI), and the European Society of Pediatric and Neonatal Intensive Care (ESPNIC). Acute lung injury in children: therapeutic practice and feasibility of international clinical trials. Pediatr Crit Care Med, 2010; 11(6):681–689; doi: 10.1097/PCC.0b013e3181d904c0
11.
MorrisJV, RamnarayanP, ParslowRC, FlemingSJ. Outcomes for children receiving noninvasive ventilation as the first-line mode of mechanical ventilation at intensive care admission: a propensity score-matched cohort study. Crit Care Med, 2017; 45(6):1045–1053; doi: 10.1097/CCM.0000000000002369
12.
AbulebdaK, CvijanovichNZ, ThomasNJ, et al.Post-ICU admission fluid balance and pediatric septic shock outcomes: a risk-stratified analysis. Crit Care Med, 2014; 42(2):397–403; doi: 10.1097/CCM.0b013e3182a64607
13.
Munoz-BonetJI, Flor-MacianEM, BrinesJ, et al.Predictive factors for the outcome of noninvasive ventilation in pediatric acute respiratory failure. Pediatr Crit Care Med, 2010; 11(6):675–680; doi: 10.1097/PCC.0b013e3181d8e303
FedorKL. Noninvasive respiratory support in infants and children. Respir Care, 2017; 62(6):699–717; doi: 10.4187/respcare.05244
16.
American Academy of Pediatrics Committee on Quality Improvement. Clinical practice guidelines of the American academy of pediatrics: A compilation of evidence-based guidelines for pediatric practice, 3rd ed. Itasca: AAP Publishing; 2000.
17.
KudchadkarS, SterniL, YasterM, EasleyRB. Sleep in the intensive care unit. Contemporary Critical Care, 2009; 7:1–12.
18.
FrieseRS. Sleep and recovery from critical illness and injury: a review of theory, current practice, and future directions. Crit Care Med, 2008; 36(3):697–705; doi: 10.1097/CCM.0B013E3181643F29
19.
KoukourikosK, TzehaL, PantelidouP, TslaglidouA. The importance of play during hospitalization for children. Mater Sociomed, 2015; 27(6):438–441; doi: 10.5455/msm.2015.27.438-441
AbmanSH, CollacoJM, ShepherdEG, et al.;on behalf of the Bronchopulmonary Dysplasia Collaborative. Interdisciplinary care of children with severe bronchopulmonary dysplasia. J Pediatr, 2017; 181:12–28.e1; doi: 10.1016/j.jpeds.2016.10.082
22.
MakkerK, JiY, HongX, WangX. Antenatal and neonatal factors contributing to extra uterine growth failure (EUGR) among preterm infants in Boston Birth Cohort (BBC). J Perinatol, 2021; 41(5):1025–1032; doi: 10.1038/s41372-021-00948-4
23.
L’HerE, DeyeN, LelloucheF, et al.Physiologic effects of noninvasive ventilation during acute lung injury. Am J Respir Crit Care Med, 2005; 172(9):1112–1118; doi: 10.1164/rccm.200402-226OC
24.
VisscherMO, WhiteCC, JonesJM, CahillT, JonesDC, PanBS. Face masks for noninvasive ventilation: fit, excess skin hydration, and pressure ulcers. Respir Care, 2015; 60(11):1536–1547; doi: 10.4187/respcare.04036
25.
PigmansRRWP, SmithJM, MarkhorstDG, et al.Current advances and gaps in knowledge on personalizing masks for noninvasive respiratory support. Respir Care, 2024; 69(9):1201–1211; doi: 10.4187/respcare.11886
26.
MortametG, AmaddeoA, EssouriS, RenolleauS, EmeriaudG, FaurouxB. Interfaces for noninvasive ventilation in the acute setting in children. Paediatr Respir Rev, 2017; 23:84–88; doi: 10.1016/j.prrv.2016.09.004
27.
Borras-NovellC, CausapieMG, MurciaM, DjianD, Garcia-AlgarO. Development of a 3D individualized mask for neonatal non-invasive ventilation. Int J Bioprint, 2022; 8(2):516–530; doi: 10.1806/3/ijb.v8i2.516
28.
WilloxM, MetherallP, Jeays-WardK, et al.Custom-made 3D printed masks for children using non-invasive ventilation: a feasibility study of production method and testing of outcomes in adult volunteers. J Med Eng Technol, 2020; 44(5):213–223; doi: 10.1080/03091902.2020.1769759
29.
Bermúdez-BarrezuetaL, Mayordomo-ColungaJ, Miñambres-RodríguezM, et al.;SEDANIV Study group of the Spanish Society for Pediatric Intensive Care. Implications of sedation during the use of noninvasive ventilation in children with acute respiratory failure (SEDANIV Study). Crit Care, 2024; 28(1):235–247. and; doi: 10.1186/s13054-024-04976-2
30.
CarrollCL, NapolitanoN, Pons-ÒdenaM, IyerNP, KorangSK, EssouriS, on behalf of the Second Pediatric Acute Lund Injury Consensus Conference (PALICC-2) of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Noninvasive respiratory support for pediatric acute respiratory distress syndrome: from the second pediatric acute lung injury consensus conference. Pediatr Crit Care Med, 2023; 24(12 Suppl 2):S135–S147; doi: 10.1097/PCC.0000000000003165
31.
EssouriS, CarrollCL, for the Pediatric Acute Lung Injury Consensus Conference Group. Noninvasive support and ventilation for pediatric acute respiratory distress syndrome: proceedings from the pediatric acute lung injury consensus conference. Pediatr Crit Care Med, 2015; 16(5 Suppl 1):S102–S110; doi: 10.1097/PCC.0000000000000437
32.
NapolitanoN, Maurice-AwityS, CarrK, SamoraR, SilvestroE. Utilizing 3-dimentional imaging technology to determine optimal sizing for pediatric NIV interfaces (abstract). Respir Care, 2023; 68(Suppl 10):3951299.
33.
KamathKA, KamathMJ, EkiciS, et al.Workflow to develop 3D designed personalized neonatal CPAP masks using iPhone structured light facial scanning. 3D Print Med, 2022; 8(1):23–35; doi: 10.1186/s41205-022-00155-7
34.
SoshnickSH, CarrollCL, CowlAS. Increased use of noninvasive ventilation associated with decreased use of invasive devices in children with bronchiolitis. Crit Care Explor, 2019; 1(8):e0026; doi: 10.1097/CCE.0000000000000026
35.
BonoraJP, FrydmanJ, RettaA, CanepariA. Post-extubation non-invasive ventilation in the pediatric intensive care unit: a multicenter study. Arch Argent Pediatr, 2018; 116(5):333–339; doi: 10.5546/aap.2018.eng.333
36.
AbadessoC, NunesP, SilvestreC, MatiasE, LoureiroH, AlmeidaH. Non-invasive ventilation in acute respiratory failure in children. Pediatric Reports, 2012; 4(2):e16–e63; doi: 10.4081/pr.2012.e16
37.
Mayordomo-ColungaJ, MedinaA, ReyC, et al.Predictive factors of non-invasive ventilation failure in critically ill children: a prospective epidemiological study. Intensive Care Med, 2009; 35(3):527–536; doi: 10.1007/s00134-008-1346-7
38.
Pons-OdenaM, MedinaA, ModestoV, et al.What are the most reliable predictive factors of non-invasive ventilation failure in paediatric intensive care units? An Pediatr, 2019; 91(5):307–316; doi: 10.1016/j.anpede.2019.01.015
39.
PiastraM, De LucaD, PietriniD, et al.Noninvasive pressure-support ventilation in immunocompromised children with ARDS: a feasibility study. Intensive Care Med, 2009; 35(8):1420–1427; doi: 10.1007/s00134-009-1558-5
40.
Fernandez-GonzalezSM, AlonsoAS, MartinezAO, Avila-AlvarezA. Incidence, predictors and outcomes of noninvasive ventilation failure in very preterm infants. Children, 2022; 9(3):426–436; doi: 10.3390/children9030426
41.
BernetV, HugMI, FreyB. Predictive factors for the success of noninvasive mask ventilation in infants and children with acute respiratory failure. Pediatr Crit Care Med, 2005; 6(6):660–664; doi: 10.1097/01.pcc.0000170612.16938.f6
42.
Mayordomo-ColungaJ, PonsM, LópezY, et al.Pediatric non-invasive ventilation failure in children from the SpO2/FiO2 (SF) ratio. Intensive Care Med, 2013; 39(6):1095–1103; doi: 10.1007/s00134-013-2880-5
43.
LumLCCS, Abdel-LatifME, de BruyneJA, NathanAM, GanCS. Noninvasive ventilation in a tertiary pediatric intensive care unit in a middle-income country. Pediatr Crit Care Med, 2011; 12(1):e7-13–e13; doi: 10.1097/PCC.0b013e3181d505f4
44.
ImDD, LaksanaE, LedbetterDR, AczonMD, KhemaniRG, WetzelRC. Development of a deep learning model that predicts Bi-level positive airway pressure failure. Sci Rep, 2022; 12(1):8907–8915; doi: 10.1038/s41598-022-12984-x
45.
FischerHS, BuhrerC. Avoiding endotracheal ventilation to prevent bronchopulmonary dysplasia: a meta-analysis. Pediatrics, 2013; 132(5):e1351-1360–e1360; doi: 10.1542/peds.2013-1880
46.
SweetDG, CarnielliVP, GreisenG, et al.European Consensus Guidelines on the Management of Respiratory Distress Syndrome: 2022 update. Neonatology, 2023; 120(1):3–23; doi: 10.1159/000528914
47.
ChungJ, IyengarA, SantryL, SwansonE, DavisJM, VolpeMV. Changes in respiratory management and the impact on bronchopulmonary dysplasia. Pediatr Pulmonol, 2022; 57(10):2327–2334; doi: 10.1002/ppul.26035
48.
LeeSM, SieL, LiuJ, ProfitJ, LeeHC. Evaluation of trends in bronchopulmonary dysplasia and respiratory support practice for very ow birth weight infants: a population-based cohort study. J Periatr, 2022; 243:47–52.
McKinneyRL, NapolitanoN, LevinJJ, et al.;on behalf of the BPD Collaborative. Ventilatory strategies in infants with established severe bronchopulmonary dysplasia: a multicenter point prevalence study. J Pediatr, 2022; 242:248–252.e1; doi: 10.1016/j.jpeds.2021.10.036
51.
ManleyBJ, HodgsonKA. Non-invasive ventilation and bronchopulmonary dysplasia: is LESS really MORE? Arch Dis Child Fetal Neonatal Ed, 2022; 107(2):118–119; doi: 10.1136/archdischild-2021-322779
52.
ChabraS, StrandjordT, PeeplesE. Prolonged non-invasive ventilation in extremely low birth weight preterm infants is associated with bronchopulmonary dysplasia. J Neonatal Perinatal Med, 2019; 12(3):249–253; doi: 10.3233/NPM-18120
53.
FischerHS, SchmolzerGM, CheungP-Y, BuhrerC. Sustained inflations and avoiding mechanical ventilation to prevent death or bronchopulmonary dysplasia: a meta-analysis. Eur Respir Rev, 2018; 27(150):180083; doi: 10.1183/16000617.0083-2018
54.
PayenV, JouvetP, LacroixJ, DucruetT, GauvinF. Risk factors associated with increased length of mechanical ventilation in children. Pediatr Crit Care Med, 2012; 13(2):152–157; doi: 10.1097/PCC.0b013e3182257a24
55.
KoppW, GedeitRG, AsaroLA, McLaughlinGE, WypijD, CurleyMAQ, Randomized Evaluation of Sedation Titration for Respiratory Failure (RESTORE) Study Investigators. The impact of preintubation noninvasive ventilation on outcomes in pediatric acute respiratory distress syndrome. Crit Care Med, 2021; 49(5):816–827; doi: 10.1097/CCM.0000000000004819
56.
EmeriaudG, NapolitanoN, PolikoffL, et al.;for the National Emergency Airway Registry for Children (NEAR4KIDS) Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI). Impact of failure of noninvasive ventilation on the safety of pediatric tracheal intubation. Crit Care Med, 2020; 48(10):1503–1512; doi: 10.1097/CCM.0000000000004500
57.
EssouriS, DurandP, ChevretL, et al.Physiological effects of noninvasive positive ventilation during acute moderate hypercapnic respiratory insufficiency in children. Intensive Care Med, 2008; 34(12):2248–2255; doi: 10.1007/s00134-008-1202-9
