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References
1.
López-Otín
C
,
Blasco
MA
,
Partridge
L
,
Serrano
M
,
Kroemer
G
. The hallmarks of aging . Cell , 2013 ; 153 :1194 –1217 .
2.
Klass
MR
. A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results . Mech Ageing Dev , 1983 ; 22 :279 –286 .
3.
Kenyon
C
,
Chang
J
,
Gensch
E
,
Rudner
A
,
Tabtiang
R. A
. C. elegans mutant that lives twice as long as wild type. Nature . 1993 ; 366 :461 –464 .
4.
Blasco
MA
,
Lee
HW
,
Hande
MP
,
Samper
E
,
Lansdorp
PM
,
DePinho
RA
,
Greider
CW
. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA . Cell , 1997 ; 91 :25 –34 .
5.
Jaskelioff
M
,
Muller
FL
,
Paik
JH
,
Thomas
E
,
Jiang
S
,
Adams
AC
,
Sahin
E
,
Kost-Alimova
M
,
Protopopov
A
,
Cadiñanos
J
,
Horner
JW
,
Maratos-Flier
E
,
DePinho
RA
. Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice . Nature , 2011 ; 469 :102 –106 .
6.
Colman
RJ
,
Anderson
RM
,
Johnson
SC
,
Kastman
EK
,
Kosmatka
KJ
,
Beasley
TM
,
Allison
DB
,
Cruzen
C
,
Simmons
HA
,
Kemnitz
JW
,
Weindruch
R
. Caloric restriction delays disease onset and mortality in rhesus monkeys . Science , 2009 ; 325 :201 –204 .
7.
Mattison
JA
,
Roth
GS
,
Beasley
TM
,
Tilmont
EM
,
Handy
AM
,
Herbert
RL
,
Longo
DL
,
Allison
DB
,
Young
JE
,
Bryant
M
,
Barnard
D
,
Ward
WF
,
Qi
W
,
Ingram
DK
,
de Cabo
R
. Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study . Nature , 2012 ; 489 :318 –321 .
