In spite of enormous efforts and accumulated knowledge, our capabilities for tackling aging and age-related diseases (ARDs), and ultimately to promote longevity, are still very modest. What is lacking—essential data on key players, efficient analytic tools, or both? Here we discuss how the existing data may be integrated and analyzed in the context of microRNA (miRNA)-regulated protein–protein interaction networks. The proposed model highlighted: (1) The strong molecular links between aging, longevity, and ARDs; (2) the possibility and even the preferability of initiating longevity-promoting interventions in adult life; (3) the potentially important role for miRNA- (or small interfering RNA [siRNA]) mediated targeting of certain genes with features of antagonistic pleiotropy; (4) the superiority of systemic interventions to the common single-target approach in curing ARDs and promoting longevity.
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