Abstract
The Strategies for Engineered Negligible Senescence (SENS) agenda contemplates specialized centers that offer a periodic rejuvenation and biogerontological maintenance for their clients. Although high-tech interventions are still in an early research phase, well-proven natural techniques, such as various forms of caloric/nutritional restriction, physical training, and preconditioning treatments, are not unanimously embraced due to poor adherence of patients. The practicability of such interventions can be significantly improved by “engineering” them for higher efficiency and better user friendliness. We describe practical experience in developing and running a prototype facility that uses rejuvenative treatment protocols, derived from two natural life span–prolonging strategies: Intermittent calorie/nutritive restriction (ICR) and intermittent oxygen restriction (IOR).
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