Abstract
The association between zinc status and lipid-related metabolic diseases, such as coronary heart disease, has produced conflicting results. Since heterogeneity of the adult population—or inter-individual variation—may impact on response to dietary zinc, nutritional genomic approaches were used to investigate the impact of age on zinc-regulated gene expression in lymphocytes. Many genes involved in lipid and cholesterol homeostasis were found to be differentially regulated by zinc in an age-dependent manner. Additionally, the individual genes affected and the extent of differential regulation varied with respect to donor age, suggesting that the age-related phenotype may alter zinc action.
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