Restricted accessResearch articleFirst published online 2025-08
Effects of a Combined Collagen Stimulation Procedure Consisting of 675 nm Laser Device and Hyaluronic Acid-Based Filler Injections for Facial Rejuvenation
There has been an increase in interest in using in-office cosmetic treatments to promote collagen in the skin and deeper tissues.
Aim:
The current study assesses the safety and efficacy of the combination of a 675 nm laser wavelength and the injection of soft tissue fillers based on hyaluronic acid (HA) during facial rejuvenation treatments.
Materials and methods:
A total of 16 patients treated for facial skin rejuvenation and reduction of facial laxity were divided into two groups: Group 1 underwent three sessions of a 675 nm laser system combined with three sessions of HA filler and Group 2 received three sessions of the 675 nm laser system alone. One treatment every 30 days for 3 months was performed. Images were acquired at baseline (T0), after the second session (Tm), and 1 month after the last treatment (Tf). A dermal analysis system was employed for skin analysis. The 10-point visual analog scale and the 5‐point Global Aesthetic Improvement Scale (GAIS) were used.
Results:
In both groups, but more promisingly in Group 1, the skin showed an improvement in its elasticity reported with an increase in Young’s modulus, a decrease in retraction time, and an increase in viscoelasticity. Qualitative analysis of high-frequency dermal ultrasound images showed significant increases in new collagen density and dermal thickness. These results were confirmed with the GAIS. No side effects were recorded.
Conclusion:
The findings indicate that the combination of 675 nm laser and HA filler was well-tolerated and safe and has shown promising results for treating skin aging.
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