Potential for Transcranial Laser or LED Therapy to Treat Stroke,Traumatic Brain Injury,and Neurodegenerative Disease

Wan S. , Parrish J.A. , Anderson R.R. , Madden M. 1981. Transmittance of nonionizing radiation in human tissues. Photochem. Photobiol., 34:679–681.

Eells J.T. et al. 2003. Therapeutic photobiomodulation for methanol-induced retinal toxicity. Proc. Natl. Acad. Sci. U.S.A., 100:3439–3444.

Wong-Riley M.T. et al. 2005. Photobiomodulation directly benefits primary neurons functionally inactivated by toxins: role of cytochrome c oxidase. J. Biol. Chem., 280:4761–4771.

Zhang L. et al. 2008. Low-power laser irradiation inhibiting Abeta25-35-induced PC12 cell apoptosis via PKC activation. Cell Physiol. Biochem., 22:215–222.

Galvan V , Jin K . 2007. Neurogenesis in the aging brain. Clin. Interv. Aging, 2:605–610.

Eriksson P.S. , Perfilieva E , Bjork–Eriksson T et al. 1998. Neurogenesis in the adult human hippocampus. Nat. Med., 4:1313–1317.

Jin K , Wang X , Xie L et al. 2006. Evidence for stroke-induced neurogenesis in the human brain. Proc. Natl. Acad. Sci. U.S.A., 103:13,198–13,202.

Lazarov O. et al. 2010. When neurogenesis encounters aging and disease. Trends Neurosci., 33:569–579.

Oron A. et al. 2006. Low-level laser therapy applied transcranially to rats after induction of stroke significantly reduces long-term neurological deficits. Stroke, 37:2620–2624.

Lapchak P.A. 2010. Taking a light approach to treating acute ischemic stroke patients: transcranial near-infrared laser therapy translational science. Ann. Med., 42:576–586.

Oron A. , Oron U. , Streeter J. et al. 2007. Low-level laser therapy applied transcranially to mice following traumatic brain injury significantly reduces long-term neurological deficits. J. Neurotrauma, 24:651–656.

Zhang R.L. , Chopp M , Zhang Z.G. et al. 1997. A rat model of focal embolic cerebral ischemia. Brain Res., 766:83–92.

Shen J. , Xie L. , Mao X. et al. 2008. Neurogenesis after primary intracerebral hemorrhage in adult human brain. J. Cereb. Blood Flow Metab., 28:1460–1468.

Detaboada L. , Ilic S. , Leichliter–Martha S. et al. 2006. Transcranial application of low-energy laser irradiation improves neurological deficits in rats following acute stroke. Lasers Surg. Med., 8:70–73.

Lapchak P.A. , De Taboada L. 2010. Transcranial near infrared laser treatment (NILT) increases cortical adenosine-5'-triphosphate (ATP) content following embolic strokes in rabbits. Brain Res., 1306:100–105.

Lampl Y. , Zivin J.A. , Fisher M. et al. 2007. Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) Stroke, 38:1843–1849.

Zivin J.A. , Albers G.W. , Bornstein N. et al. 2009. Effectiveness and safety of transcranial laser therapy for acute ischemic stroke. Stroke, 40:1359–1364.

Stemer A.B. , Huisa B.N. , Zivin J.A. 2010. The evolution of transcranial laser therapy for acute ischemic stroke, including a pooled analysis of NEST-1 and NEST-2. Curr. Cardiol. Rep., 12:29–33.

Naeser M.A. , Alexander M.P. , Stiassny–Eder D. et al. 1995. Laser acupuncture in treatment of paralysis in stroke patients: CT scan lesion site study. Am. J. Acupuncture, 23:13–28.

Naeser M.A. , Alexander M.P. , Stiassny–Eder D. et al. 1994a. Acupuncture in the treatment of paralysis in chronic and acute stroke patients: improvement correlated with specific CT scan lesion sites. Acupunct. Electrother. Res., 19:227–249.

Naeser M.A. , Alexander M.P. , Stiassny–Eder D. et al. 1994b. Acupuncture in the treatment of hand paresis in chronic and acute stroke patients: improvement observed in all cases. Clin. Rehabil., 8:127–141.

Hashmi J.T. , Huang Y.Y. , Osmani B.Z. , Sharma S.K. , Naeser M.A. , Hamblin M.R. 2010. Role of low-level laser therapy in neurorehabilitation. Arch. Phys. Med. Rehab. Suppl. 2:S292–S305.

Faul M. , Xu L. , Wald M.M. , Coronado V.G. 2010. Traumatic brain Injury in the United States: emergency department visits, hospitalizations and deaths. Atlanta: Centers for Disease Control and Prevention.

Finkelstein E. , Corso P. , Miller T. 2006. The incidence and economic burden of injuries in the United States. New York: Oxford University Press.

Cicerone K. , Levin H. , Malec J. , Stuss D. , Whyte J. 2006. Cognitive rehabilitation interventions for executive function: moving from bench to bedside in patients with traumatic brain injury. J. Cogn. Neurosci., 18:1212–1222.

Hoge C.W. , McGurk D. , Thomas J.L. et al. 2008. Mild traumatic brain injury in U.S. soldiers returning from Iraq. N. Engl. J. Med., 358:453–463.

Taber K.H. , Warden D.L. , Hurley R.A. 2006. Blast-related traumatic brain injury: what is known? J Neuropsychiatry Clin Neurosci, 18:141–145.

Niogi S.N. et al. 2008. Extent of microstructural white matter injury in postconcussive syndrome correlates with impaired cognitive reaction time: a 3T DTI study, mild TBI. A.J.N.R. Am. J. Neuroradiol., 29:967–973.

Moreira M.S. , Velasco I.T. , Ferreira L.S. et al. 2009. Effect of phototherapy with low intensity laser on local and systemic immunomodulation following focal brain damage in rat. J. Photochem. Photobiol. B, 97:145–151.

Wu Q. HY-Y. , Dhital S. , Sharma S.K. et al. 2010. Low level laser therapy for traumatic brain injury. Proc. S.P.I.E., 7552:755206–1.

Naeser M.A. , Saltmarche A. , Krengel M.H. , Hamblin M.R. , Knight J.A. 2011. Improved cognitive function after-transcranial, light-emitting diode treatments in chronic, traumatic brain injury: two case reports. Photomed. Laser Surg., 29:351–358.

Frost E. 1976. Acupuncture for the comatose patient. Am. J. Acupunct., 4:45–48.

Deadman P. , Al-Khafaji M. 1998. A manual of acupuncture. Hove, East Essex, England: Journal of Chinese Medicine Publications pp. 256, 325:548–560.

Mi X.Q. , Chen J.Y. , Liang Z.J. et al. 2004. In vitro effects of helium–neon laser irradiation on human blood: blood viscosity and deformability of erythrocytes. Photomed. Laser Surg., 22:477–482.

Mi X.Q. , Chen J.Y. , Cen Y. et al. 2004. A comparative study of 632.8 and 532 nm laser irradiation on some rheological factors in human blood in vitro. J. Photochem. Photobiol. B, 74:7–12.

Schiffer F. , Johnston A.L. , Ravichandran C. et al. 2009. Psychological benefits 2 and 4 weeks after a single treatment with NIR light to the forehead: a pilot study of 10 patients with major depression and anxiety. Behav. Brain Funct., 5:46.

De Taboada L. et al. 2011. Transcranial laser therapy attenuates amyloid–beta peptide neuropathology in amyloid–beta protein precursor transgenic mice. J. Alzheimers Dis., 23:521–535.

Moges H. et al. 2009. Light therapy and supplementary Riboflavin in the SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis (FALS) Lasers Surg. Med., 41:52–59.

Trimmer P.A. et al. 2009. Reduced axonal transport in Parkinson's disease cybrid neurites is restored by light therapy. Mol. Neurodegener., 4:26.

Komel'kova L.V. et al. 2004. Biochemical and immunological induces of the blood in Parkinson's disease and their correction with the help of laser therapy. Patol. Fiziol. Eksp. Ter., 1:15–8.

Perera T.D. , Park S. , Nemirovskaya Y. 2008. Cognitive role of neurogenesis in depression and antidepressant treatment. Neuroscientist, 14:326–338.