Abstract
Background:
CD71+ erythroid cells (CECs) play a complex immunoregulatory role.
Methods:
Flow cytometry was used to assess CECs in 84 individuals, from preterm infants to adults, divided into 5 age groups, 12 from infants under 6 months, 16 from young children (6 months–5 years), 24 from children (6–10 years), 22 from adolescents (11–19 years), and 10 from adults (≥20 years).
Results:
CECs are universally present at very low frequencies, except in individuals younger than 6 months (P < 0.001). Although preterm infants tended to have a higher median CECs than full-term infants, this difference was not statistically significant. Among individuals over 6 months, CECs showed significant negative correlations with hemoglobin (r = −0.448, P < 0.001) and hematocrit (r = −0.416, P < 0.001), but no such correlations were found in younger infants.
Conclusions:
CECs are present across all age groups, with higher levels in early infancy.
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