Abstract
Background:
Although serum levels of squamous cell carcinoma antigen (SCCA) are elevated in atopic dermatitis (AD), their clinical utility has not been fully elucidated.
Methods:
Thirty-three cases of AD who admitted to our hospital were analyzed.
Results:
Baseline characteristics on admission were as follows: median age 19 months [interquartile range (IQR), 12–52 months], median objective severity scoring of atopic dermatitis (O-SCORAD) 19.2 (IQR, 4.2–36.0), and median serum SCCA levels 3.2 ng/mL (IQR, 2.1–6.8 ng/mL). O-SCORAD significantly correlated with serum SCCA levels (rs = 0.865, P < 0.001). In 9 cases whose information before and after treatment was available (median interval, 3 days; IQR 2–5 days), median serum SCCA levels significantly decreased from 8.0 to 2.0 ng/mL (P = 0.008) after the treatment.
Conclusions:
Serum levels of total SCCA rapidly declined in response to the treatment and could be used as a real-time biomarker in childhood AD.
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