Decreased CD5 − CD19 + CD27 + CD43 + CD70 − B-Cell Subpopulation in Children with Specific Antibody Deficiency

Abstract

Purpose:

Recent studies have reported that CD19⁺CD20⁺CD27⁺CD43⁺CD70^-CD5⁻ B cells produce IgG, IgA, and IgM antibodies to Streptococcus pneumoniae (Spn). In one adult patient with specific antibody deficiency (SAD), the percentage of CD5⁻ CD19⁺CD20⁺CD27⁺CD43⁺CD70⁻ B cells was decreased. The percentages of CD5⁻of CD19⁺CD27⁺CD43⁺CD70⁻ B cells in children with SAD were examined in this study.

Methods:

Clinical and immunologic studies were obtained from a review of medical records. The percentages of CD5⁻ of CD19⁺CD27⁺CD43⁺CD70⁻ B cells were determined by flow cytometry.

Results:

Patients with SAD had significantly decreased percentages of CD5⁻ of CD19⁺CD27⁺CD43⁺CD70⁻ B cells. There was a significant correlation between decreased percentage of CD5⁻of CD19⁺CD27⁺CD43⁺CD70⁻ B cells and decreased percentage of protective antibody titers to Spn.

Conclusion:

Decreased percentage of CD5⁻ of CD19⁺CD27⁺CD43⁺CD70⁻ B cells were identified in patients with SAD and correlated with decreased antibody responses to Spn.