The aims of this study were to identify hub genes and to analyze gene expression patterns related to infants with acute respiratory infections (ARI) of respiratory syncytial virus (RSV), human rhinovirus (HRV), and influenza A. Transcriptome data of GSE38900 were obtained from the Gene Expression Omnibus database. The differentially expressed genes (DEGs) related to three groups (RSV, HRV, and influenza A) were respectively identified based on the Linear Models for Microarray Data package, comparing samples infected with one virus (cases) to those infected with the other two viruses as well as healthy matched subjects (controls). Prediction of microRNAs and transcription factors were performed based on the Molecular signatures database. The protein–protein interaction (PPI) network and its modules were constructed. Functional and pathway enrichment analyses were performed based on the expression analysis systematic explore test. We identified 840 common DEGs among the three groups. Several microRNAs and transcription factors were revealed. The PPI network of common DEGs was constructed, and five modules in the PPI network were mined. CTNNB1, YWHAE, DDB1, RPL5, PLCG1, SHC1, PPP2R2B, and PML were hub genes in the dysregulation network. These genes were involved in ribosomal function, biochemical reaction activity, signal transduction, and cell death. In conclusion, this study presented hub genes in infants with ARI of RSV, HRV, and influenza A (ARIs-RHI). Moreover, the dysregulation of ribosomal genes combined with gene expression patterns in ARIs-RHI were also revealed.
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